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Frisoni GB, Louhija J, Geroldi C, et al. Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. J Gerontol A Biol Sci Med Sci. 2001;56(2):M75-8doi: 10.1093/gerona/56.2.m75.
Frisoni, G. B., Louhija, J., Geroldi, C., & Trabucchi, M. (2001). Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. The journals of gerontology. Series A, Biological sciences and medical sciences, 56(2), M75-8. https://doi.org/10.1093/gerona/56.2.m75
Frisoni, G B, et al. "Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 56,2 (2001): M75-8. doi: https://doi.org/10.1093/gerona/56.2.m75
Frisoni GB, Louhija J, Geroldi C, Trabucchi M. Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. J Gerontol A Biol Sci Med Sci. 2001 Feb;56(2):M75-8. doi: 10.1093/gerona/56.2.m75. PMID: 11213279.
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J Gerontol A Biol Sci Med Sci. 2001 Feb;56(2):M75-8. doi: 10.1093/gerona/56.2.m75.

Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study.

The journals of gerontology. Series A, Biological sciences and medical sciences

G B Frisoni, J Louhija, C Geroldi, M Trabucchi

Affiliations

  1. Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio-FBF, Brescia, Italy. [email protected]

PMID: 11213279 DOI: 10.1093/gerona/56.2.m75

Abstract

BACKGROUND: Whether and which genetic factors affect human longevity is unclear. This study assesses the association between the epsilon2 allele of apolipoprotein E (APOE), a putative longevity gene, and extremely old age.

METHODS: This study is based on all centenarians living in Finland in 1991. Subjects were 179 persons (28 men and 151 women) aged 100 years and older (response rate, 97%).

RESULTS: The percentages of epsilon2-allele carriers in persons aged 100 to 101, 102 to 103, and 104 years and older were 9% (10/117), 21% (9/42), and 25% (5/20; gender-adjusted p for trend = .01), respectively. The effect was particularly strong in women: 8% (8/100), 18% (6/33), and 28% (5/18; p for trend = .01) by age group, respectively. Low cell numbers prevented clear conclusions being drawn for men. Seventeen percent (30/179) of the adult Finnish population were carriers of the epsilon4 allele, a figure lower than expected, and stable by age group.

CONCLUSIONS: Carriers of the epsilon2 allele of APOE might be predisposed to reach extremely old age.

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