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Wagner G, Montorsi F, Auerbach S, et al. Sildenafil citrate (VIAGRA) improves erectile function in elderly patients with erectile dysfunction: a subgroup analysis. J Gerontol A Biol Sci Med Sci. 2001;56(2):M113-9doi: 10.1093/gerona/56.2.m113.
Wagner, G., Montorsi, F., Auerbach, S., & Collins, M. (2001). Sildenafil citrate (VIAGRA) improves erectile function in elderly patients with erectile dysfunction: a subgroup analysis. The journals of gerontology. Series A, Biological sciences and medical sciences, 56(2), M113-9. https://doi.org/10.1093/gerona/56.2.m113
Wagner, G, et al. "Sildenafil citrate (VIAGRA) improves erectile function in elderly patients with erectile dysfunction: a subgroup analysis." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 56,2 (2001): M113-9. doi: https://doi.org/10.1093/gerona/56.2.m113
Wagner G, Montorsi F, Auerbach S, Collins M. Sildenafil citrate (VIAGRA) improves erectile function in elderly patients with erectile dysfunction: a subgroup analysis. J Gerontol A Biol Sci Med Sci. 2001 Feb;56(2):M113-9. doi: 10.1093/gerona/56.2.m113. PMID: 11213274.
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J Gerontol A Biol Sci Med Sci. 2001 Feb;56(2):M113-9. doi: 10.1093/gerona/56.2.m113.

Sildenafil citrate (VIAGRA) improves erectile function in elderly patients with erectile dysfunction: a subgroup analysis.

The journals of gerontology. Series A, Biological sciences and medical sciences

G Wagner, F Montorsi, S Auerbach, M Collins

Affiliations

  1. University of Copenhagen, Division of Sexual Physiology, Rigshospitalet, Denmark.

PMID: 11213274 DOI: 10.1093/gerona/56.2.m113

Abstract

BACKGROUND: The prevalence of erectile dysfunction (ED) increases with advancing age, with a particularly high prevalence of ED in elderly patients with diabetes. In the United States it is estimated that approximately 45% of men aged 65 to 69 years have moderate or complete ED. The efficacy and safety of oral sildenafil (VIAGRA) for treating ED in elderly men (aged > or = 65 years or older) were assessed.

METHODS: We analyzed data obtained from five double-blind, placebo-controlled studies of the efficacy and tolerability of oral sildenafil taken as required (but not more than once daily) over a 12-week to 6-month period. Two subgroups were evaluated: (i) elderly patients with ED of broad-spectrum etiology (n = 411), and (ii) elderly patients with ED and diabetes (n = 71). Efficacy was assessed using a global efficacy question, questions 3 and 4 of the International Index of Erectile Function (IIEF). and the five sexual function domains of the IIEF.

RESULTS: All efficacy assessments indicated that sildenafil significantly improved erectile function both in elderly patients with ED of broad-spectrum etiology and in elderly patients with ED and diabetes. The most common adverse events were mild-to-moderate headache, flushing, and dyspepsia. The rates of discontinuation due to adverse events were low and were comparable to the rates with placebo.

CONCLUSIONS: Sildenafil is an efficacious and well-tolerated treatment for ED in elderly men.

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