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Surg Today. 2000;30(8):683-8. doi: 10.1007/s005950070078.

Nitrite/nitrate (NOx) levels and hemodynamics during septic shock.

Surgery today

H Nakae, S Endo, M Kikuchi, Y Yamada, M Shibata, H Ishikura, T Tanaka, G Wakabayashi, T Kawamura, K Inada, S Sato

Affiliations

  1. Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.

PMID: 10955729 DOI: 10.1007/s005950070078

Abstract

Nitric oxide (NO) acts as a vasorelaxant. We investigated the relationship between nitrite/nitrate (NOx), which are the final metabolites of NO, and hemodynamics during septic shock. We also examined tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), and endotoxin. A significant negative correlation was observed between NOx levels and pulmonary capillary wedge pressure (PCWP; r = -0.6075, P = 0.0028). A significant positive correlation was noted between NOx levels and the cardiac index (CI; r = 0.5934, P = 0.0038). A significant negative correlation was found between NOx levels and the systemic vascular resistance index (SVRI; r = -0.4354, P = 0.0485). A significant positive correlation was observed between NOx levels and the stroke volume index (SVI; r = 0.5040, P = 0.0186). A significantly close positive correlation was also observed between TNF-alpha levels and NOx levels (r = 0.7848, P < 0.0001). These findings suggest that NOx levels are closely associated with hemodynamics during septic shock, resulting in a vascular relaxing effect.

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