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Zuń M, Czarnecki W. The dissolution kinetics of sulfamethoxazol, trimethoprim and oxytetracycline hydrochloride from multicomponent solid dispersion capsules ("Sulfoxytrim"). Acta Pol Pharm. 2000;57(2):97-100
Zuń, M., & Czarnecki, W. (2000). The dissolution kinetics of sulfamethoxazol, trimethoprim and oxytetracycline hydrochloride from multicomponent solid dispersion capsules ("Sulfoxytrim"). Acta poloniae pharmaceutica, 57(2), 97-100.
Zuń, M, and Czarnecki, W. "The dissolution kinetics of sulfamethoxazol, trimethoprim and oxytetracycline hydrochloride from multicomponent solid dispersion capsules ("Sulfoxytrim")." Acta poloniae pharmaceutica vol. 57,2 (2000): 97-100.
Zuń M, Czarnecki W. The dissolution kinetics of sulfamethoxazol, trimethoprim and oxytetracycline hydrochloride from multicomponent solid dispersion capsules ("Sulfoxytrim"). Acta Pol Pharm. 2000 Mar-Apr;57(2):97-100. PMID: 10934786.
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Acta Pol Pharm. 2000 Mar-Apr;57(2):97-100.

The dissolution kinetics of sulfamethoxazol, trimethoprim and oxytetracycline hydrochloride from multicomponent solid dispersion capsules ("Sulfoxytrim").

Acta poloniae pharmaceutica

M Zuń, W Czarnecki

Affiliations

  1. Department of Applied Pharmacy, University of Medicine, Lublin, Poland.

PMID: 10934786

Abstract

Release profiles and dissolution kinetics of active substance, viz. sulfamethoxazol (SMO), trimethoprim (TMP), and oxytetracycline hydrochloride (OTC) from capsulated multicomponent dispersions was studied in a flow-cell apparatus at 37 degrees C by using a dissolution medium of 0.1 mol/l HCl. The results revealed that the relative dissolution efficiency (DE) and dissolution profiles of one active ingredient were affected by the presence of the two others. Vitamin C added caused the decreased the dissolution rate constants (K) and DE--values of all the active substances studied.

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