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Psychiatr Genet. 2000 Mar;10(1):33-7. doi: 10.1097/00041444-200010010-00006.

Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia.

Psychiatric genetics

T Bowen, C A Guy, A G Cardno, J B Vincent, J L Kennedy, L A Jones, M Gray, R D Sanders, G McCarthy, K C Murphy, M J Owen, M C O'Donovan

Affiliations

  1. Division of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK. [email protected]

PMID: 10909126 DOI: 10.1097/00041444-200010010-00006

Abstract

A number of studies using the repeat expansion detection (RED) technique have suggested an association between unknown large CAG/CTG repeats and schizophrenia. The polymorphic CAG/CTG repeat loci CTG18.1 and ERDA1 have been reported to account for a high proportion (approximately 90%) of the large repeats detected by RED and may therefore be responsible for the cited association. The recently described locus TGC13-7a contains a highly polymorphic CTA/TAG and CAG/CTG composite repeat, and is thus another authentic candidate. In the present investigation, each locus was analysed for association with schizophrenia in a sample of 206 patients and 219 group-matched controls. No evidence for association of CTG18.1, ERDA1 and/or TGC13-7a with schizophrenia was found. The combined data accounted for only 54% of the CAG/CTG arrays of > 40 repeats found in our previous RED analysis.

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