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Priestly BG, Plaa GL. Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals. Arch Int Pharmacodyn Ther. 1976;223(1):132-41
Priestly, B. G., & Plaa, G. L. (1976). Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals. Archives internationales de pharmacodynamie et de therapie, 223(1), 132-41.
Priestly, B G, and Plaa, G L. "Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals." Archives internationales de pharmacodynamie et de therapie vol. 223,1 (1976): 132-41.
Priestly BG, Plaa GL. Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals. Arch Int Pharmacodyn Ther. 1976 Sep;223(1):132-41. PMID: 999392.
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Arch Int Pharmacodyn Ther. 1976 Sep;223(1):132-41.

Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals.

Archives internationales de pharmacodynamie et de therapie

B G Priestly, G L Plaa

PMID: 999392

Abstract

Male mice treated with nicotine hydrochloride either acutely (5 mg/kg i.p.) or subchronically (5 mg/kg i.p. daily for 3 weeks; 25 mg/liter in drinking water for 2-3 months) showed no evidence of hepatic dysfunction, as measured by serum glutamic-pyruvic transaminase or serum alkaline phosphatase activities. Neither acute nor subchronic administration modified the hepatotoxic response to a potent hepatotoxin (carbon tetrachloride), nor that of less potent hepatotoxins chloroform or 1, 1, 1-trichloroethane, nor was the cholestatic effect of alpha-naphthylisothiocyanate modified.

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