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Arch Int Pharmacodyn Ther. 1976 Sep;223(1):132-41.

Hepatic function after acute of subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals.

B G Priestly, G L Plaa

PMID: 999392


Male mice treated with nicotine hydrochloride either acutely (5 mg/kg i.p.) or subchronically (5 mg/kg i.p. daily for 3 weeks; 25 mg/liter in drinking water for 2-3 months) showed no evidence of hepatic dysfunction, as measured by serum glutamic-pyruvic transaminase or serum alkaline phosphatase activities. Neither acute nor subchronic administration modified the hepatotoxic response to a potent hepatotoxin (carbon tetrachloride), nor that of less potent hepatotoxins chloroform or 1, 1, 1-trichloroethane, nor was the cholestatic effect of alpha-naphthylisothiocyanate modified.

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