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Kubota H, Okada K, Sato K, et al. HLA-DR expression of synovium and correlation with clinical features of patients with rheumatoid arthritis. Tohoku J Exp Med. 2000;190(3):177-84doi: 10.1620/tjem.190.177.
Kubota, H., Okada, K., Sato, K., & Sageshima, M. (2000). HLA-DR expression of synovium and correlation with clinical features of patients with rheumatoid arthritis. The Tohoku journal of experimental medicine, 190(3), 177-84. https://doi.org/10.1620/tjem.190.177
Kubota, H, et al. "HLA-DR expression of synovium and correlation with clinical features of patients with rheumatoid arthritis." The Tohoku journal of experimental medicine vol. 190,3 (2000): 177-84. doi: https://doi.org/10.1620/tjem.190.177
Kubota H, Okada K, Sato K, Sageshima M. HLA-DR expression of synovium and correlation with clinical features of patients with rheumatoid arthritis. Tohoku J Exp Med. 2000 Mar;190(3):177-84. doi: 10.1620/tjem.190.177. PMID: 10778801.
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Tohoku J Exp Med. 2000 Mar;190(3):177-84. doi: 10.1620/tjem.190.177.

HLA-DR expression of synovium and correlation with clinical features of patients with rheumatoid arthritis.

The Tohoku journal of experimental medicine

H Kubota, K Okada, K Sato, M Sageshima

Affiliations

  1. Department of Orthopedic Surgery, Akita University School of Medicine, Japan.

PMID: 10778801 DOI: 10.1620/tjem.190.177

Abstract

To investigate whether the expression of human leukocyte antigen-DR (HLA-DR) in synovial tissues obtained at synovectomy contributes to the clinical features of patients with rheumatoid arthritis (RA), immunohistochemical analysis was performed to determine the intensity and pattern of HLA-DR expression in synovial tissue from 96 patients with RA. The clinical features before and 1 year after the synovectomy were investigated. At the time of the surgery, duration of morning stiffness was associated with the degree of HLA-DR expression in synovial lining layer, and this synovial lining expression of HLA-DR was more frequently observed in elbow and wrist joints than in knee joint. In patients who underwent knee synovectomy, erythrocyte sedimentation rate and C-reactive protein level one year after the surgery were significantly higher in the patients with intense expression of HLA-DR in the synovial lining. Our findings showed that the expression of HLA-DR in the synovial lining contributes to several clinical features, and the expression in large joint such as knee may related with disease course of patients with RA.

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