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Johnson ML, duBuy HG. Effect of a potent interferon inducer on acute and chronic lactic dehydrogenase virus viremia. Infect Immun. 1975;11(1):113-6doi: 10.1128/iai.11.1.113-116.1975.
Johnson, M. L., & duBuy, H. G. (1975). Effect of a potent interferon inducer on acute and chronic lactic dehydrogenase virus viremia. Infection and immunity, 11(1), 113-6. https://doi.org/10.1128/iai.11.1.113-116.1975
Johnson, M L, and duBuy, H G. "Effect of a potent interferon inducer on acute and chronic lactic dehydrogenase virus viremia." Infection and immunity vol. 11,1 (1975): 113-6. doi: https://doi.org/10.1128/iai.11.1.113-116.1975
Johnson ML, duBuy HG. Effect of a potent interferon inducer on acute and chronic lactic dehydrogenase virus viremia. Infect Immun. 1975 Jan;11(1):113-6. doi: 10.1128/iai.11.1.113-116.1975. PMID: 1116871; PMCID: PMC415033.
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Atypon Free PMC Article

Infect Immun. 1975 Jan;11(1):113-6. doi: 10.1128/iai.11.1.113-116.1975.

Effect of a potent interferon inducer on acute and chronic lactic dehydrogenase virus viremia.

Infection and immunity

M L Johnson, H G duBuy

PMID: 1116871 PMCID: PMC415033 DOI: 10.1128/iai.11.1.113-116.1975
Free PMC Article

Abstract

The effect of a single and multiple doses of polyinosinic-polycytidylic acid (poly (I). poly(C) on lactic dehydrogenase virus viremia has been studied. A single injection of 200 mug of poly (I)-poly(C) given 6 h before infection with lactic dehydrogenase virus caused a temporary decrease in viremia of about 2.5 log10. Repeated injections of 100 mug of poly(I)-poly(C) every 24 h beginning at -24 h caused a temporary decrease in viremia of about 4.0 log 10. Therapeutic treatment with optimal dosage schedules (100 mug every 24 h) caused a reduction in viremia of 1.0 to 2.0 log10. This decrease lasted for at least 24 h after the treatment was stopped. Some possible reasons for the limited effectiveness of poly (I)-poly(C) in this system are discussed.

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