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Veyries ML, Faurisson F, Joly-Guillou ML, et al. Control of staphylococcal adhesion to polymethylmethacrylate and enhancement of susceptibility to antibiotics by poloxamer 407. Antimicrob Agents Chemother. 2000;44(4):1093-6doi: 10.1128/AAC.44.4.1093-1096.2000.
Veyries, M. L., Faurisson, F., Joly-Guillou, M. L., & Rouveix, B. (2000). Control of staphylococcal adhesion to polymethylmethacrylate and enhancement of susceptibility to antibiotics by poloxamer 407. Antimicrobial agents and chemotherapy, 44(4), 1093-6. https://doi.org/10.1128/AAC.44.4.1093-1096.2000
Veyries, M L, et al. "Control of staphylococcal adhesion to polymethylmethacrylate and enhancement of susceptibility to antibiotics by poloxamer 407." Antimicrobial agents and chemotherapy vol. 44,4 (2000): 1093-6. doi: https://doi.org/10.1128/AAC.44.4.1093-1096.2000
Veyries ML, Faurisson F, Joly-Guillou ML, Rouveix B. Control of staphylococcal adhesion to polymethylmethacrylate and enhancement of susceptibility to antibiotics by poloxamer 407. Antimicrob Agents Chemother. 2000 Apr;44(4):1093-6. doi: 10.1128/AAC.44.4.1093-1096.2000. PMID: 10722521; PMCID: PMC89822.
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Antimicrob Agents Chemother. 2000 Apr;44(4):1093-6. doi: 10.1128/AAC.44.4.1093-1096.2000.

Control of staphylococcal adhesion to polymethylmethacrylate and enhancement of susceptibility to antibiotics by poloxamer 407.

Antimicrobial agents and chemotherapy

M L Veyries, F Faurisson, M L Joly-Guillou, B Rouveix

Affiliations

  1. INSERM EPI 9933, Bichat-Claude Bernard Hospital, Paris, France. [email protected]

PMID: 10722521 PMCID: PMC89822 DOI: 10.1128/AAC.44.4.1093-1096.2000

Abstract

We studied the antiadhesive effect of Poloxamer 407 (P407), together with modifications in the antimicrobial susceptibility of residual adherent staphylococci. Bacterial adherence was markedly inhibited (77% to more than 99.9%) whether polymethylmethacrylate was exposed to P407 before or during the adherence assay. Furthermore, residual adherent staphylococci appeared to be more susceptible to antibiotic activity, suggesting that combination of P407 with antibiotics could be a promising approach to the prevention of infection of foreign material.

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