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Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14692-3. doi: 10.1073/pnas.96.26.14692.

A cyclodextrin dimer with a photocleavable linker as a possible carrier for the photosensitizer in photodynamic tumor therapy.

Proceedings of the National Academy of Sciences of the United States of America

A Ruebner, Z Yang, D Leung, R Breslow

Affiliations

  1. Department of Chemistry, Columbia University, New York, NY 10027, USA.

PMID: 10611274 PMCID: PMC24709 DOI: 10.1073/pnas.96.26.14692

Abstract

A cyclodextrin dimer has been synthesized with two beta-cyclodextrins linked by a flexible chain containing a carbon-carbon double bond. This dimer binds and solubilizes a phthalocyanine-based photosensitizer that generates singlet oxygen on irradiation. When the complex is irradiated, the singlet oxygen cleaves the carbon-carbon link, and the cyclodextrins are released, liberating the photosensitizer into the light path. Ideas about how this phenomenon could be used to make photodynamic tumor therapy into a more selective process are described.

References

  1. J Natl Cancer Inst. 1998 Jun 17;90(12):889-905 - PubMed
  2. J Biol Chem. 1967 Sep 25;242(18):4149-56 - PubMed

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