Farmakol Toksikol. 1976 Jun-Aug;39(4):474-7.

[Antifibrotic properties of lidase in experimental berylliosis].

Farmakologiia i toksikologiia

[Article in Russian]
A L Ivanova

PMID: 1027575

Abstract

The effect of lidase with its inhalation against the background of a fibrotic process in the lungs was studied on a model of experimental berylliosis provoked in rats through intratracheal administration of 5 mg of Be (OH)2. The degree of fibrosis was assessed according to the dry residue in the lungs, content therein of oxyproline, hexosamines and hexuronic acids. Lidase was found not only to delay the development of the affections but also to lower the level of fibrosis existing prior to the treatment. The therapeutic effect of the compound continued for a comparatively long time.

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Substances

• Hexosamines
• Hexuronic Acids
• Hyaluronoglucosaminidase
• Hydroxyproline

MeSH terms

• Animals
• Berylliosis*
• Drug Evaluation
• Female
• Hexosamines / metabolism
• Hexuronic Acids / metabolism
• Hyaluronoglucosaminidase / therapeutic use
• Hydroxyproline / metabolism
• Lung / metabolism
• Poisoning / complications
• Pulmonary Fibrosis / drug therapy
• Pulmonary Fibrosis / etiology
• Pulmonary Fibrosis / metabolism
• Rats

Publication Types

• English Abstract
• Journal Article