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Koyama K, Ito Y. Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris. Parasite Immunol. 2000;22(1):13-20doi: 10.1046/j.1365-3024.2000.00270.x.
Koyama, K., & Ito, Y. (2000). Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris. Parasite immunology, 22(1), 13-20. https://doi.org/10.1046/j.1365-3024.2000.00270.x
Koyama, K, and Ito, Y. "Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris." Parasite immunology vol. 22,1 (2000): 13-20. doi: https://doi.org/10.1046/j.1365-3024.2000.00270.x
Koyama K, Ito Y. Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris. Parasite Immunol. 2000 Jan;22(1):13-20. doi: 10.1046/j.1365-3024.2000.00270.x. PMID: 10607287.
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Parasite Immunol. 2000 Jan;22(1):13-20. doi: 10.1046/j.1365-3024.2000.00270.x.

Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris.

Parasite immunology

K Koyama, Y Ito

Affiliations

  1. Department of Parasitology, Kitasato University School of Medicine, 1-15-1, Kitasato, Sagamihara, Kanagawa 228-8555, Japan.

PMID: 10607287 DOI: 10.1046/j.1365-3024.2000.00270.x

Abstract

The involvement of mucosal mast cells (MMC) in protection against infection with the murine nematode parasite Trichuris muris was studied in genetically mast cell-deficient WBB6F1-W/Wv mice and their normal littermates WBB6F1-+/+ mice. Expulsion of T. muris worms occurred in infected +/+ mice, whereas no worm expulsion was observed in infected W/Wv mice where the infection persisted until at least day 46 postinfection. No MMC responses were induced in either infected W/Wv or +/+ mice. Specific IgG1and IgG2a antibodies to T. muris excretory/secretory antigens were observed in infected W/Wv and +/+ mice, and antibody production showed similar kinetics. Interleukin 4 production by concanavalin A (Con A)-stimulated mesenteric lymph node cells (MLNC) was induced preferentially in infected +/+ mice. T. muris infection increased the levels of IFN-gamma produced by Con A-stimulated MLNC of infected W/Wv and +/+ mice, with the levels of IFN-gamma in infected W/Wv mice being higher than those in infected +/+ mice. Taken together, these results indicate that W/Wv and +/+ mice are susceptible and resistant to T. muris infection, respectively, and that MMC responses are not required for protective immunity.

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