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Ion channels activated by quinolinic acid in cultured rat hippocampal neurons.

Brain research

Tsuzuki K, Iino M, Ozawa S.
PMID: 2470467
Brain Res. 1989 Mar 06;481(2):258-64. doi: 10.1016/0006-8993(89)90802-0.

The membrane responses to quinolinic acid, an excitotoxic brain metabolite, were studied in cultured rat hippocampal neurons with the patch-clamp technique. In the whole-cell recording mode, pressure applications of quinolinic acid elicited inwardly directed membrane currents over a membrane...

Stimulation of the N-methyl-D-aspartate receptor promotes the biochemical differentiation of cerebellar granule neurons and not astrocytes.

Brain research

Moran J, Patel AJ.
PMID: 2470476
Brain Res. 1989 May 01;486(1):15-25. doi: 10.1016/0006-8993(89)91272-9.

Cerebellar granule cells are believed to be glutamatergic, but, as they receive excitatory amino acidergic input from mossy fibers, they also possess N-methyl-D-aspartate (NMDA) receptors. The possible involvement of these NMDA receptors in the biochemical differentiation of cultured granule...

Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsin and elastase.

Journal of medicinal chemistry

Kinder DH, Katzenellenbogen JA.
PMID: 3851848
J Med Chem. 1985 Dec;28(12):1917-25. doi: 10.1021/jm00150a027.

A series of 1-acylamino boronic acids (IA-VA), analogues of the amino acids phenylalanine, phenylglycine, alanine, valine, and isoleucine, were prepared as potential transition-state inhibitors of the serine proteases alpha-chymotrypsin and elastase, by a boronate homologation reaction. The corresponding difluoroboranes...

Mössbauer effect studies on some bioinorganic complexes of europium.

Journal of inorganic biochemistry

Niu CJ, Jia YQ, Liu ML, Liu XW, Jin MZ.
PMID: 1634891
J Inorg Biochem. 1992 Feb 15;45(3):151-7. doi: 10.1016/0162-0134(92)80040-3.

The bioinorganic complexes of europium with N-acetyl-DL-alanine, N-acetyl-DL-valine, and DL-alanyl-DL-alanine have been synthesized and the Mössbauer spectra at room temperature have been measured for these solid state complexes. The Mössbauer parameters indicate that the water molecules in these complexes...

Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist.

Neuroscience letters

Avoli M, Olivier A.
PMID: 2884608
Neurosci Lett. 1987 May 06;76(2):249-54. doi: 10.1016/0304-3940(87)90724-5.

Intracellular recordings were performed in human neocortical neurons in 'in vitro' slices of brain samples excised during surgical treatment of epilepsy. In 14 of 38 neurons obtained from cortex exhibiting interictal spiking, bursts of action potentials arising from a...

Involvement of N-methyl-D-aspartate receptors in the augmenting response in rat neocortex.

Neuroscience letters

Addae JI, Stone TW.
PMID: 2888063
Neurosci Lett. 1987 Aug 05;78(3):323-7. doi: 10.1016/0304-3940(87)90381-8.

The augmenting response was elicited in the neocortex of anaesthetized rats by 10 Hz stimulation of thalamic nuclei. The N-methyl-aspartate (NMA) antagonists 2-amino-5-phosphonopentanoate or 2-amino-7-phosphonoheptanoate were applied topically to the exposed cortex by replacement of fluid in a small...

Biological and chemical monitoring of occupational exposure to ethylene oxide.

Mutation research

Tates AD, Grummt T, Törnqvist M, Farmer PB, van Dam FJ, van Mossel H, Schoemaker HM, Osterman-Golkar S, Uebel C, Tang YS.
PMID: 1719390
Mutat Res. 1991 Sep-Oct;250(1):483-97. doi: 10.1016/0027-5107(91)90205-3.

Studies were carried out on two populations occupationally exposed to ethylene oxide (EtO) using different physical and biological parameters. Blood samples were collected from 9 hospital workers (EI) and 15 factory workers (EII) engaged in sterilization of medical equipment...

Nitrogen balance of uremic patients receiving branched-chain ketoacids and the hydroxy-analogue of methionine as substitutes for the respective amino acids.

Clinical nephrology

Mitch W, Walser M.
PMID: 891047
Clin Nephrol. 1977 Aug;8(2):341-4.

The efficacy of the D,L-alpha-hydroxy analogue of methionine and the alpha-keto analogues of valine, leucine and isoleucine as substitutes for the corresponding amino acids was tested by measuring the nitrogen balance of chronic uremic patients receiving glycine as their...

GEA 857 blocks potassium channels in the membrane and, thereby, prolongs muscarinic cholinergic responses in N1E-115 neuroblastoma cells.

Pharmacology & toxicology

Hedlund B, Ogren SO.
PMID: 1301072
Pharmacol Toxicol. 1992 Aug;71(2):107-11. doi: 10.1111/j.1600-0773.1992.tb00528.x.

GEA 857 [2-(4-chlorophenyl)-1,1-dimethylethyl 2-amino-3-methylbutanoate], a structural analogue of the serotonin (5-HT) uptake inhibitor alaprocalate but without effects on the 5-HT uptake, was shown to potentiate muscarinic cholinergic responses in N1E-115 neuroblastoma cells. In intracellular recording experiments, GEA 857 (1...

Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo.

British journal of pharmacology

Connick JH, Stone TW.
PMID: 2898959
Br J Pharmacol. 1988 Apr;93(4):868-76. doi: 10.1111/j.1476-5381.1988.tb11474.x.
Free PMC Article

1. The effect of quinolinic acid, N-methyl-D,L-aspartate (NMDLA) and kainate on the release of endogenous and exogenous amino acids from the rat cerebral cortex in vitro and in vivo was studied. 2. Neither quinolinic acid nor NMDLA had any...

Modification of the anticonvulsant activity of 2-amino-5-phosphonovalerate by agents affecting different neurotransmitter systems.


Czuczwar SJ, Turski L, Chmielewska B, Turski WA, Kleinrok Z.
PMID: 2866464
Neuropharmacology. 1985 Oct;24(10):965-8. doi: 10.1016/0028-3908(85)90123-6.

The effects of atropine (5 mg/kg), baclofen (10 mg/kg), gamma-hydroxybutyrate (300 mg/kg), gamma-butyrolactone (100 mg/kg) and muscimol (1 mg/kg) upon the action of 2-amino-5-phosphonovalerate (APV; an antagonist at receptors for N-methyl-D-aspartate) on the threshold current for seizures induced by...

Effects of D-(-)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid.

Neuroscience letters

Lason W, Simpson JN, McGinty JF.
PMID: 2898113
Neurosci Lett. 1988 Apr 22;87(1):23-8. doi: 10.1016/0304-3940(88)90139-5.

In rats, the seizures induced by systemic kainic acid (KA) are followed by extensive neuronal damage, notably in the hippocampal region. We report that the specific N-methyl-D-aspartate (NMDA) receptor antagonist, D-(-)-aminophosphonovalerate (D(-)APV), given i.c.v. prior to or 2 h...

Showing 1 to 12 of 5416 entries