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Characterization of the receptor mediating relaxation to substance P in canine middle cerebral artery: no evidence for involvement of substance P in neurogenically mediated relaxation.

British journal of pharmacology

Stubbs CM, Waldron GJ, Connor HE, Feniuk W.
PMID: 1380374
Br J Pharmacol. 1992 Apr;105(4):875-80. doi: 10.1111/j.1476-5381.1992.tb09071.x.
Free PMC Article

1. The aim of this study was to characterize the neurokinin receptor which mediates relaxation of dog isolated middle cerebral artery by the use of selective agonists and antagonists and to establish whether substance P is involved in the...

Effects of tetradecapeptide renin substrate on isolated preparations of rat caudal artery, guinea-pig atria and on pithed rat blood pressure.

Clinical and experimental pharmacology & physiology

Ziogas J, Story DF, Rand MJ.
PMID: 3015458
Clin Exp Pharmacol Physiol. 1986 Apr;13(4):271-6. doi: 10.1111/j.1440-1681.1986.tb00347.x.

In rat isolated caudal artery preparations, tetradecapeptide renin substrate enhanced the responses to sympathetic nerve stimulation (0.5 Hz, 10 s). In guinea-pig isolated atria, previously incubated in 3H-noradrenaline, tetradecapeptide renin substrate enhanced the stimulation-induced efflux of radioactivity. The facilitation...

Propranolol blocks recurrent synaptic activation in paravertebral sympathetic ganglia of bullfrogs.

Neuroscience letters

Nishimura T, Akasu T.
PMID: 2837680
Neurosci Lett. 1988 Apr 12;86(3):306-10. doi: 10.1016/0304-3940(88)90501-0.

Intracellular recordings were made from neurons in bullfrog sympathetic ganglia. Orthodromic, intracellular and antidromic stimulations evoked recurrent depolarizing responses accompanied by a spontaneous firing of the action potential in type 2 neurons. The depolarizing response elicited by intracellular and...

L-serine-O-phosphate blocks NMDA-evoked responses in the ampullae of Lorenzini of skates.


Akoev GN, Andrianov GN, Ryzhova IV, Sherman NO.
PMID: 1351755
Neuroreport. 1992 Jan;3(1):7-9. doi: 10.1097/00001756-199201000-00001.

In the present study, we have shown by single afferent unit recording in the organs of Lorenzini that L-serine-O-phosphate (L-SOP) decreases the resting discharge frequency as well as electrically evoked responses. L-SOP in a concentration of 0.1-100 microM antagonizes...

Calcium and transmitter release.

International review of neurobiology

Cohen I, Van der Kloot W.
PMID: 2867980
Int Rev Neurobiol. 1985;27:299-336. doi: 10.1016/s0074-7742(08)60560-7.

No abstract available.

Interaction between the renin-angiotensin-aldosterone and sympathetic nervous systems.

Journal of cardiovascular pharmacology

Saxena PR.
PMID: 1382170
J Cardiovasc Pharmacol. 1992;19:S80-8. doi: 10.1097/00005344-199219006-00013.

The renin-angiotensin-aldosterone system is mainly involved in the regulation of arterial blood pressure and fluid balance. One of the main stimuli for the secretion of renin present in the renal juxtamedullary cells, but also in some other tissues, is...

Dopaminergic influence on the effects of angiotensin II in behavioural reactions.

Physiologia Bohemoslovaca

Georgiev V, György L, Yonkov D, Getova D, Markovska V, Petkova B.
PMID: 3014581
Physiol Bohemoslov. 1985;34:45-8.

Using a neuropharmacological approach we studied the dopaminergic influence on the effects of angiotensin II (ATII) in some behavioural reactions. Haloperidol reduced the exploratory behaviour-increasing effect of ATII in the open field. Haloperidol also reduced the apomorphine stereotypy-increasing effect...

Pathophysiology of L-dopa-induced abnormal involuntary movements.

Psychopharmacology. Supplementum

Agid Y, Bonnet AM, Ruberg M, Javoy-Agid F.
PMID: 2987904
Psychopharmacology Suppl. 1985;2:145-59. doi: 10.1007/978-3-642-70140-5_19.

Among the various deficiencies in neurotransmitters and neuropeptides in the brains of patients with Parkinson's disease, the loss of dopamine (DA) is implicated in a major way in the occurrence of L-dopa-induced abnormal involuntary movements (AIMs). Whatever the clinical...

Possible involvement of adenine nucleotides in the neurotransmission of the mouse urinary bladder.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

Acevedo CG, Contreras E.
PMID: 2866909
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(2):357-61. doi: 10.1016/0742-8413(85)90176-8.

The urinary bladder of the mouse contracts to several agonists, namely acetylcholine, noradrenaline, adrenaline, histamine, angiotensin, serotonin, purine nucleotides and prostaglandin F2 alpha. Atropine partially reduced the contraction induced by electrical stimulation, whereas propranolol and tolazoline were ineffective. The...

Trazodone and the mental pain hypothesis of depression.


Silvestrini B.
PMID: 3014372
Neuropsychobiology. 1986;15:2-9. doi: 10.1159/000118270.

The mental pain hypothesis used to develop trazodone is illustrated, together with its medical and methodological implications. Trazodone possesses a well documented antidepressant activity, which indirectly confirms the above hypothesis. It lacks the aminergic effects of other antidepressants and...

Inhalation anaesthetics exhibit pathway-specific and differential actions on hippocampal synaptic responses in vitro.

British journal of anaesthesia

MacIver MB, Roth SH.
PMID: 2837263
Br J Anaesth. 1988 May;60(6):680-91. doi: 10.1093/bja/60.6.680.
Free Article

The effects of halothane, isoflurane and enflurane were compared on three CNS excitatory synaptic pathways in vitro, to determine whether selective actions described in vivo result from differential effects on anatomically distinct cortical pathways and neurone populations. Halothane (0.25-1.25...

Neuropharmacology of methylphenidate and a neural substrate for childhood hyperactivity.

The Psychiatric clinics of North America

Gualtieri CT, Hicks RE.
PMID: 2867534
Psychiatr Clin North Am. 1985 Dec;8(4):875-92.

What began as a simple chemical question about the clinical utility of MPH SL measurement has led our group across a broad expanse of research endeavors, from the problem of nonintercorrelated stimulant effects to a theory of hyperactivity as...

Showing 1 to 12 of 19650 entries