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Showing 1 to 12 of 5458 entries
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Molecular biology of adrenergic receptors.

Journal of hypertension

Strasser RH, Ihl-Vahl R, Marquetant R.
PMID: 1320069
J Hypertens. 1992 Jun;10(6):501-6. doi: 10.1097/00004872-199206000-00001.

No abstract available.

Desmethylimipramine attenuates cocaine withdrawal in rats.


Markou A, Hauger RL, Koob GF.
PMID: 1365631
Psychopharmacology (Berl). 1992;109(3):305-14. doi: 10.1007/BF02245878.

Depression and anhedonia are two major symptoms of cocaine withdrawal in humans. Hence, pharmacological treatments effective in depression might also alleviate the symptoms of cocaine withdrawal. In the present study, the effects of acute and repeated administration of a...

Dihydrotestosterone decreases beta-adrenergic receptor binding in the fetal rabbit lung.

American journal of perinatology

Moawad AH, River LP, River JM.
PMID: 2838034
Am J Perinatol. 1988 Jul;5(3):283-5. doi: 10.1055/s-2007-999704.

Tritium-labeled dihydroalprenolol was used to quantify the beta-adrenergic receptor sites in day 30 fetal rabbit lung tissue. Each of the fetuses of New Zealand White rabbits on day 28 of gestation was injected with dihydrotestosterone (2.0 micrograms) in one...

Regulation of cyclic AMP metabolism by muscarinic cholinergic receptors.

Advances in cyclic nucleotide and protein phosphorylation research

Harden TK, Evans T, Hepler JR, Hughes AR, Martin MW, Meeker RB, Smith MM, Tanner LI.
PMID: 2988297
Adv Cyclic Nucleotide Protein Phosphorylation Res. 1985;19:207-20.

The occurrence of muscarinic cholinergic receptor-mediated activation of phosphodiesterase in 1321N1 cells does not represent an isolated phenomenon, since a similar response to cholinergic stimuli is observed in thyroid slices (45) and WI-38 fibroblasts (1,42). Both muscarinic-receptor-mediated inhibition of...

Vitamin E and selenium regulate balance between beta-adrenergic and muscarinic responses in rat lungs.

FEBS letters

Doelman CJ, Kramer K, Timmerman H, Bast A.
PMID: 2838338
FEBS Lett. 1988 Jun 20;233(2):427-31. doi: 10.1016/0014-5793(88)80476-9.
Free Article

The effects of hydrogen peroxide on the beta-adrenergic and muscarinic responses of the rat trachea muscle were studied in vitro, after feeding rats, for 6 weeks, either a diet deficient in vitamin E and selenium or a control diet....

Pharmacological characterization of chick and frog beta adrenergic receptors in primary cultures of myocardial cells.

The Journal of pharmacology and experimental therapeutics

Port JD, Debellis CC, Klein J, Peeters GA, Barry WH, Bristow MR.
PMID: 1352549
J Pharmacol Exp Ther. 1992 Jul;262(1):217-24.

In membrane preparations derived from primary cultures of chick myocardial cells, beta adrenergic receptors modeled for a single low-affinity site for both betaxolol (beta-1-selective) and ICI 118551 (beta-2-selective) displacement of [125I]iodocyanopindolol (ICYP), indicating that the chick beta receptor is...

Reflex vagal withdrawal and the hemodynamic response to intravenous isoproterenol in the presence of beta-antagonists.

Clinical pharmacology and therapeutics

Arnold JM, McDevitt DG.
PMID: 3015474
Clin Pharmacol Ther. 1986 Aug;40(2):199-208. doi: 10.1038/clpt.1986.164.

To investigate the contribution of reflex vagal tone to the hemodynamic response after intravenous isoproterenol, 12 healthy subjects received isoproterenol by both bolus injection and continuous infusion before and after atropine, and during intravenous infusion of the beta 1-selective...

Newly synthesized alpha 1-adrenoceptor blockers (SM911 and SM2470) and characterization of alpha-adrenoceptors in rat aortic strips, rat vas deferens preparations and rabbit aortic strips.

General pharmacology

Takayanagi I, Konno F, Arai H, Chimoto K, Kitada T.
PMID: 2867950
Gen Pharmacol. 1985;16(6):613-5. doi: 10.1016/0306-3623(85)90152-1.

Alpha 1-adrenergic potencies of SM911 and SM2470, whose chemical structures are similar to that of prazosin, a selective alpha 1-adrenoceptor blocker, were tested in rabbit aortic strips, rat aortic strips and rat vas deferens preparations. SM2470 was as potent...

Studies on rat brain catecholamine synthesis and beta-adrenoceptor number following administration of electroconvulsive shock, desipramine and clenbuterol.

Journal of neural transmission

Nimgaonkar VL, Heal DJ, Davies CL, Green AR.
PMID: 3011985
J Neural Transm. 1986;65(3):245-59. doi: 10.1007/BF01249086.

The effects of administration to rats of repeated electroconvulsive shock (ECS), clenbuterol and desipramine (DMI) on beta-adrenoceptor number in cortex, and noradrenaline (NA) and dopamine (DA) turnover in whole brain has been investigated by examining the rate of decline...

Impaired beta-adrenergic receptor and normal postreceptor responsiveness in congestive heart failure.

The American journal of cardiology

Erne P, Lipkin D, Maseri A.
PMID: 2834939
Am J Cardiol. 1988 May 01;61(13):1132-4. doi: 10.1016/0002-9149(88)90146-4.

No abstract available.

Indole-phenol bioisosterism. Synthesis and antihypertensive activity of a pyrrolo analogue of labetalol.

Journal of medicinal chemistry

Asselin AA, Humber LG, Crosilla D, Oshiro G, Wojdan A, Grimes D, Heaslip RJ, Rimele TJ, Shaw CC.
PMID: 3012084
J Med Chem. 1986 Jun;29(6):1009-15. doi: 10.1021/jm00156a019.

The synthesis of 5-[hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-1H-indole-7- carboxamide, 5, a pyrrolo analogue of labetalol, is described. Compound 5 was found to reduce blood pressure in spontaneously hypertensive rats with an ED50 of 5 mg/kg po, without causing any decrease in heart rate....

Characteristics of beta-adrenoceptors in tracheal smooth muscle of guinea pig sensitized by egg albumin.

Canadian journal of physiology and pharmacology

Nakagoshi A, Koike K, Takayanagi I.
PMID: 2896535
Can J Physiol Pharmacol. 1987 Nov;65(11):2163-7. doi: 10.1139/y87-341.

The effect of pretreatment with egg albumin was examined on the beta-adrenoceptors in guinea pig isolated trachea. Befunolol and carteolol acted as partial agonists and their pA2 values were significantly larger than their corresponding pD2 values in tracheae from...

Showing 1 to 12 of 5458 entries