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Comparison of polymerase chain reaction, DNA hybridization, and histology with viral culture to detect cytomegalovirus in immunosuppressed patients.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Persons DL, Moore JA, Fishback JL.
PMID: 1646452
Mod Pathol. 1991 Mar;4(2):149-53.

Formalin-fixed, paraffin-embedded lung tissue from 34 autopsies and eight open-lung biopsies of bone marrow transplant recipients was analyzed for cytomegalovirus (CMV) infection. The cases were studied by the polymerase chain reaction (PCR), in situ DNA hybridization, and histologic examination....

Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy.

Proceedings of the National Academy of Sciences of the United States of America

Shoffner JM, Lott MT, Voljavec AS, Soueidan SA, Costigan DA, Wallace DC.
PMID: 2554297
Proc Natl Acad Sci U S A. 1989 Oct;86(20):7952-6. doi: 10.1073/pnas.86.20.7952.
Free PMC Article

The muscle mitochondria of a patient with Kearns-Sayre/chronic external ophthalmoplegia plus syndrome were found to be completely deficient in respiratory complex I activity and partially deficient in complex IV and V activities. Treatment of the patient with coenzyme Q10...

Post-transcriptional regulation of gro alpha, beta, gamma, and IL-8 mRNAs by IL-1 beta.

Nucleic acids research

Stoeckle MY.
PMID: 2017372
Nucleic Acids Res. 1991 Feb 25;19(4):917-20. doi: 10.1093/nar/19.4.917.
Free PMC Article

Expression of the cytokine gene gro, also known as melanoma growth stimulatory activity, is induced by inflammatory stimuli, including IL-1. To determine whether gro expression is regulated at a post-transcriptional level, the effect of IL-1 on gro mRNA stability...

Application of polymerase chain reaction to detect activated oncogenes in hematological malignancies.

Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society

Ishikawa F, Kobayashi Y.
PMID: 2629464
Nihon Ketsueki Gakkai Zasshi. 1989 Dec;52(8):1433-41.

Polymerase chain reaction (PCR) was applied to detect the structural change accompanying the activation of oncogenes in hematological malignancies and preleukemic states. Point mutation of N-ras oncogene was examined by oligonucleotide differential hybridization coupled with PCR. Five out of...

Expression of the androgen receptor gene in rat penile tissue and cells during sexual maturation.


Gonzalez-Cadavid NF, Swerdloff RS, Lemmi CA, Rajfer J.
PMID: 1874196
Endocrinology. 1991 Sep;129(3):1671-8. doi: 10.1210/endo-129-3-1671.

The cessation of rat and human penile growth at completion of sexual maturation appears to be related to a tissue-specific decrease in the number of androgen receptors (AR) in the penis. To find out whether this is due to...

Atrial natriuretic factor mRNA and binding sites in the adrenal gland.

The Biochemical journal

Nunez DJ, Davenport AP, Brown MJ.
PMID: 2146954
Biochem J. 1990 Oct 15;271(2):555-8. doi: 10.1042/bj2710555.
Free PMC Article

The factor inhibiting aldosterone secretion produced by the adrenal medulla may be atrial natriuretic factor (ANF), since the latter abolishes aldosterone release in response to a number of secretagogues, including angiotensin II and K+. In this study we have...

Localization of the microsatellite probe DXS426 between DXS7 and DXS255 on Xp and linkage to X-linked retinitis pigmentosa.

American journal of human genetics

Coleman M, Bhattacharya S, Lindsay S, Wright A, Jay M, Litt M, Craig I, Davies K.
PMID: 2239970
Am J Hum Genet. 1990 Dec;47(6):935-40.
Free PMC Article

The microsatellite marker DXS426 maps to the interval Xp21.1-Xp11.21, the chromosomal region which contains two loci for X-linked retinitis pigmentosa (XLRP; RP2 and RP3). We have refined the localization of DXS426 both physically, by mapping it to a deletion...

PCR amplification of HIV-1 proteinase sequences directly from lab isolates allows determination of five conserved domains.


Fontenot G, Johnston K, Cohen JC, Gallaher WR, Robinson J, Luftig RB.
PMID: 1529522
Virology. 1992 Sep;190(1):1-10. doi: 10.1016/0042-6822(92)91186-x.

HIV-1 replication requires limited proteolysis of gag and gag-pol encoded precursor proteins by a specific viral proteinase (PR). Sequences of 20 different HIV-1 strains were compared in order to determine regions of conservation and variability within the PR gene....

Autosomal dominant retinitis pigmentosa: absence of the rhodopsin proline----histidine substitution (codon 23) in pedigrees from Europe.

American journal of human genetics

Farrar GJ, Kenna P, Redmond R, McWilliam P, Bradley DG, Humphries MM, Sharp EM, Inglehearn CF, Bashir R, Jay M.
PMID: 2239971
Am J Hum Genet. 1990 Dec;47(6):941-5.
Free PMC Article

In exon 1 at codon 23 of the rhodopsin gene, a mutation resulting in a proline-to-histidine substitution has previously been observed in approximately 12% of American autosomal dominant retinitis pigmentosa (ADRP) patients. The region around the site of this...

Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. II. Determination of molecular genetic origins of rearrangements.

The Journal of clinical investigation

Conboy J, Marchesi S, Kim R, Agre P, Kan YW, Mohandas N.
PMID: 2384598
J Clin Invest. 1990 Aug;86(2):524-30. doi: 10.1172/JCI114739.
Free PMC Article

Protein 4.1 is an approximately 80-kD structural protein in the membrane skeleton which underlies and supports the erythrocyte plasma membrane. The preceding companion paper presents a biochemical study of two abnormal protein 4.1 species from individuals with the red...

Point mutation of c-Ki-ras oncogene in gastric adenoma and adenocarcinoma with tubular differentiation.

Japanese journal of cancer research : Gann

Kihana T, Tsuda H, Hirota T, Shimosato Y, Sakamoto H, Terada M, Hirohashi S.
PMID: 1902452
Jpn J Cancer Res. 1991 Mar;82(3):308-14. doi: 10.1111/j.1349-7006.1991.tb01847.x.
Free PMC Article

The presence of point mutation at codons 12, 13 and 61 of the c-Ki-ras oncogene was investigated in 7 cases of gastric adenoma and 35 cases of gastric adenocarcinoma using DNA samples from formalin-fixed and paraffin-embedded tissues. Oligonucleotides encompassing...

[Defection of viral DNA in latent infection of HHV-6].

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme

Kondo K, Yamanishi K, Takahashi M.
PMID: 1962870
Tanpakushitsu Kakusan Koso. 1990 Dec;35(17):3041-7.

No abstract available.

Showing 1 to 12 of 247227 entries