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[Alcohol dehydrogenase--polymorphism, properties and role in ethanol metabolism].

Postepy higieny i medycyny doswiadczalnej

Chrostek L, Szmitkowski M.
PMID: 1293588
Postepy Hig Med Dosw. 1992;46(4):403-15.

The paper presents the molecular and kinetics aspects of alcohol dehydrogenase polymorphism. The role of this enzyme in ethanol metabolism are too discussed.

Binding and functional effects of atrial natriuretic factor in isolated rat kidney.

The American journal of physiology

Suzuki M, Almeida FA, Nussenzveig DR, Sawyer D, Maack T.
PMID: 2961276
Am J Physiol. 1987 Nov;253(5):F917-28. doi: 10.1152/ajprenal.1987.253.5.F917.

A new methodological approach was developed to study the relationship between specific binding and dose-response curves of the renal effects of atrial natriuretic factor (ANF) in isolated perfused rat kidneys (IK). IK were perfused with 125I-labeled and unlabeled ANF...

Pharmacokinetic considerations on Orgaran (Org 10172) therapy.


Danhof M, de Boer A, Magnani HN, Stiekema JC.
PMID: 1379967
Haemostasis. 1992;22(2):73-84. doi: 10.1159/000216298.

Pharmacokinetic investigations on Orgaran (Org 10172) have been conducted by monitoring the following biological effects: plasma anti-Xa, anti-IIa and IIa-generation-inhibiting (IIaGI) activities. In addition, a limited number of studies were conducted on the basis of concentrations of the No-affinity...

The consequences of doxorubicin quinone reduction in vivo in tumour tissue.

Biochemical pharmacology

Cummings J, Willmott N, Hoey BM, Marley ES, Smyth JF.
PMID: 1472081
Biochem Pharmacol. 1992 Dec 01;44(11):2165-74. doi: 10.1016/0006-2952(92)90343-h.

A clear role for quinone reduction in the mechanism of action of doxorubicin has still to be established. There are three possible outcomes of this form of doxorubicin metabolism: (1) drug free radical formation, redox cycling and generation of...

Effect of PEG 400, ethanol and laurocapram (Azone) on the transport of testosterone through rat skin.

Die Pharmazie

Singh J, Satyanarayana S, Singh S.
PMID: 1293619
Pharmazie. 1992 Dec;47(12):948-9.

No abstract available.

Impact of imipenem/cilastatin on cyclosporine metabolism and excretion.

Transplantation proceedings

Mraz W, Modic PK, Hammer C.
PMID: 1412804
Transplant Proc. 1992 Oct;24(5):1704-8.

No abstract available.

Cyclosporine dosage according to pharmacokinetic profiles leads to better graft and patient survival rates and a decrease in cyclosporine consumption.

Transplantation proceedings

Masri MA, Dhawan VS, Hayes K, Karim T, Pingle A.
PMID: 1412808
Transplant Proc. 1992 Oct;24(5):1718-20.

No abstract available.

[Experimental chronic phenylmercuric chloride poisoning in pigs].

Veterinarni medicina

Raszyk J, Docekalová H, Rubes J, Navrátil S, Masek J, Rodák L.
PMID: 1413400
Vet Med (Praha). 1992 Jul;37(7):379-91.

Four gilts, sisters from one litter, aged 70 days and weighing 20-24 kg, were used for a trial. Two experimental gilts (P) were administered an experimental feed mixture containing phenylmercury chloride (40 mg/kg). Two control gilts (K) were fed...

Organic cation transport by rat liver plasma membrane vesicles: studies with tetraethylammonium.

The American journal of physiology

Moseley RH, Jarose SM, Permoad P.
PMID: 1443152
Am J Physiol. 1992 Nov;263(5):G775-85. doi: 10.1152/ajpgi.1992.263.5.G775.

Recently, an organic cation:H+ antiport was selectively identified on the sinusoidal domain of rat liver with the use of the endogenous organic cation N1-methylnicotinamide (NMN). Absence of NMN+:H+ exchange on canalicular membrane suggested that this transport process was primarily...

Pharmacokinetics following a single intravenous administration and a dosage regimen for sulfadoxine in buffalo calves (Bubalus bubalis).

Veterinary research communications

Srivastava AK, Chaudhary RK, Bal MS.
PMID: 1413482
Vet Res Commun. 1992;16(3):215-9. doi: 10.1007/BF01839158.

No abstract available.

Synthesis and biodistribution of an 123I labelled flunitrazepam derivative: a potential in vivo tracer for benzodiazepine receptors.

International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes

Zecca L, Ferrario P.
PMID: 2838440
Int J Rad Appl Instrum A. 1988;39(4):353-6. doi: 10.1016/0883-2889(88)90029-9.

A method for the synthesis of no-carrier-added of 7-[123I]iodo-1,3-dihydro-5-(2-fluorophenyl)-1-methyl-2H-1,4- benzodiazepine-2-one with a radiochemical yield of 25-30% has been developed. This benzodiazepine was prepared by reaction of [123I]iodide with the corresponding piperidyltriazene in acid medium and the reaction has been...

Beta-adrenergic blockade for the treatment of hyperthyroidism.

The American journal of medicine

Geffner DL, Hershman JM.
PMID: 1352658
Am J Med. 1992 Jul;93(1):61-8. doi: 10.1016/0002-9343(92)90681-z.

PURPOSE: To review the clinical and biochemical effects of beta-adrenergic blocking drugs on hyperthyroidism.MATERIALS AND METHODS: Studies published since 1972 were identified through a computerized search of MEDLINE and extensive searching of the bibliographies of the articles identified. Based...

Showing 1 to 12 of 302067 entries