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Effects of streptozotocin-induced hyperglycemia on agonist-stimulated phosphatidylinositol turnover in rat aorta.

Life sciences

Legan E.
PMID: 2528045
Life Sci. 1989;45(5):371-8. doi: 10.1016/0024-3205(89)90622-x.

Altered vascular sensitivity and responsiveness has been previously described in various stages of experimental diabetes mellitus. Increases in membrane bound Ca2+ and intracellular calcium in diabetic aorta have been postulated to explain excitation-coupling dysfunction in diabetic vascular smooth muscle...

Serotonin potentiates noradrenaline-induced vasoconstriction through 5-HT1-type receptors in guinea pig basilar artery.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Chang JY, Owman C.
PMID: 2777937
J Cereb Blood Flow Metab. 1989 Oct;9(5):713-6. doi: 10.1038/jcbfm.1989.100.

Based on the previous finding that 5-hydroxytryptamine (5-HT) co-exists with norepinephrine (NE) in cerebrovascular sympathetic nerve fibers and can be released during electrical nerve stimulation, the postjunctional interaction between the two amines was studied in isolated basilar artery of...

Noradrenergic influence on epithelial responses of rabbit ileum to secretagogues.

The American journal of physiology

Hubel KA, Renquist KS, Varley G.
PMID: 2719113
Am J Physiol. 1989 May;256(5):G919-24. doi: 10.1152/ajpgi.1989.256.5.G919.

Norepinephrine is one of three neurotransmitters that may act directly on enterocytes to enhance absorption; its interaction with secretagogues is of physiological importance. We have studied the influence of norepinephrine on the short-circuit current (Isc) responses to acetylcholine (ACh;...

Pathophysiological background for the use of calcium antagonists.

Journal of cardiovascular pharmacology

Aoki K, Sato K.
PMID: 2412008
J Cardiovasc Pharmacol. 1985;7:S28-32. doi: 10.1097/00005344-198507004-00006.

Correlation between blood pressure (BP) and total peripheral vascular resistance (TPR), hypotensive mechanisms of calcium antagonists, and cardiovascular responses to norepinephrine with and without administration of calcium antagonists were investigated in normotensive and genetic essential hypertensive humans. Supine resting...

The acetylcholine-hypersensitive model of diabetic KK-CA(y) mice analyzed with pulse rate, and modified by repeated cold stress and by adrenalectomy.

Journal of pharmacobio-dynamics

Kimura I, Matsui T, Kimura M.
PMID: 2093125
J Pharmacobiodyn. 1990 Nov;13(11):672-80. doi: 10.1248/bpb1978.13.672.

The effects of acetylcholine on pulse rate were examined in the conscious state of diabetic KK-CA(y) male mice. By subcutaneously-administered acetylcholine at 3 and 10 mg/kg the pulse rate was increased in the prediabetic state, whereas it was decreased...

Adrenergic secretory responses of submandibular tissues from control subjects and cystic fibrosis patients.

Clinica chimica acta; international journal of clinical chemistry

McPherson MA, Dormer RL, Dodge JA, Goodchild MC.
PMID: 2412733
Clin Chim Acta. 1985 Jun 14;148(3):229-37. doi: 10.1016/0009-8981(85)90149-4.

Adrenergic secretory responses of submandibular glands from control subjects and cystic fibrosis patients have been studied in vitro. In control tissues, isoproterenol (10 mumol/l) and noradrenaline (10 mumol/l) increased release of mucins and amylase to a similar extent (approximately...

Effects of 3,4-diaminopyridine and tetraethylammonium on the pre- and post-junctional alpha-adrenoceptor mediated inhibitory actions of noradrenaline in the guinea-pig ileum.

British journal of pharmacology

Bauer V.
PMID: 2411318
Br J Pharmacol. 1985 May;85(1):171-7. doi: 10.1111/j.1476-5381.1985.tb08844.x.
Free PMC Article

The effects of potassium channel blockers, 3,4-diaminopyridine (DAP) and tetraethylammonium (TEA) were studied on the pre- and post-junctional alpha 2-adrenoceptor mediated effects of noradrenaline in the guinea-pig proximal ileum. Both DAP (4 to 500 mumol l-1) and TEA (0.3...

The properties of the clonidine withdrawal response of guinea-pig isolated ileum.

British journal of pharmacology

Chahl LA.
PMID: 2411324
Br J Pharmacol. 1985 Jun;85(2):457-62. doi: 10.1111/j.1476-5381.1985.tb08882.x.
Free PMC Article

The dependence-inducing effects of clonidine were investigated on the guinea-pig isolated ileum. Clonidine produced relaxation of the ileum with a threshold concentration between 0.01 and 0.1 mumol 1(-1). Washout of clonidine did not induce a withdrawal contraction. Following 2...

Effects of angiotensin II on pressor responses to norepinephrine in humans.

Life sciences

Smith DH, Neutel JM, Weber MA.
PMID: 2046466
Life Sci. 1991;48(25):2413-21. doi: 10.1016/0024-3205(91)90375-l.

In previous studies in the conscious rabbit and in isolated artery preparations, low doses of angiotensin II synergistically amplified the pressor effects of the sympathetic neurotransmitter, norepinephrine (NE). To determine whether these observations could be replicated in humans, 9...

Distribution of excitatory junction potential amplitude in cat cerebral arteries: examination of its quantal nature and modulation by opiates.

Journal of cellular physiology

Madden JA, Kalbfleisch JH, Harder DR.
PMID: 2438292
J Cell Physiol. 1987 May;131(2):262-6. doi: 10.1002/jcp.1041310217.

We used scorpion venom to release small amounts of an excitatory neurotransmitter from adventitial nerves in cat left anterior descending cerebral artery. We used glass microelectrodes to measure and record postsynaptic electrical events of minimal amplitude. These events were...

The influence of the initial stretch and the agonist-induced tone on the effect of basal and stimulated release of EDRF.

British journal of pharmacology

Dainty IA, McGrath JC, Spedding M, Templeton AG.
PMID: 2207498
Br J Pharmacol. 1990 Aug;100(4):767-73. doi: 10.1111/j.1476-5381.1990.tb14090.x.
Free PMC Article

1. The effects of initial stretch and degree of agonist-induced tone on acetylcholine-induced relaxations were examined in rings of rat isolated aorta. The relaxation to acetylcholine was antagonized by atropine and almost completely abolished by haemoglobin. Relaxation to sodium...

The actions of endothelins-1 and -3 on the vascular and capsular smooth muscle of the isolated blood perfused spleen of the dog.

British journal of pharmacology

Withrington PG, Ansari N, Croxton R, de Nucci G, Vane JR.
PMID: 1559137
Br J Pharmacol. 1992 Feb;105(2):490-4. doi: 10.1111/j.1476-5381.1992.tb14281.x.
Free PMC Article

1. Endothelin-1 (ET-1), endothelin-3 (ET-3) and noradrenaline (NA) were administered as intra-arterial bolus injections into the isolated, blood-perfused spleen of the dog to assess agonist properties and relative molar potencies on the vascular and capsular smooth muscle. 2. An...

Showing 1 to 12 of 29627 entries