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Antiinflammatory agent BW 755 C in ischemic reperfused porcine hearts.

Journal of cardiovascular pharmacology

Klein HH, Pich S, Bohle RM, Lindert S, Nebendahl K, Buchwald A, Schuff-Werner P, Kreuzer H.
PMID: 2464107
J Cardiovasc Pharmacol. 1988 Sep;12(3):338-44. doi: 10.1097/00005344-198809000-00012.

The effect of the antiinflammatory compound BW 755 C on myocardial infarctions was evaluated in regionally ischemic reperfused hearts of 35 pigs. The left anterior descending coronary artery was occluded distally in 23 anesthetized pigs for 45 min and...

Prevention of ischemia-reperfusion injury by the allergy drug lodoxamide tromethamine.

The Annals of thoracic surgery

Parenteau GL, Clark RE.
PMID: 1929638
Ann Thorac Surg. 1991 Oct;52(4):832-8. doi: 10.1016/0003-4975(91)91220-p.

Lodoxamide tromethamine, an orphan antiallergy drug, inhibits degranulation of mast cells that reside in the myocardium and inhibits xanthine oxidase located in myocytes and predominantly in the vascular endothelium. The hypothesis evaluated was that lodoxamide tromethamine would attenuate oxygen...

F(ab')2 fragments of anti-Mo1 (904) monoclonal antibodies do not prevent myocardial stunning.

Circulation research

Schott RJ, Nao BS, McClanahan TB, Simpson PJ, Stirling MC, Todd RF, Gallagher KP.
PMID: 2551527
Circ Res. 1989 Oct;65(4):1112-24. doi: 10.1161/01.res.65.4.1112.

To determine if inhibition of leukocyte adhesion and aggregation could improve postischemic ventricular dysfunction ("stunning"), a monoclonal antibody (904) that binds to the adhesion-promoting Mo1 glycoprotein on the cell surface of leukocytes was administered intravenously (0.5 mg/kg) to open-chest...

Acute impairment of endothelium-dependent relaxations to aggregating platelets following reperfusion injury in canine coronary arteries.

Circulation research

Pearson PJ, Schaff HV, Vanhoutte PM.
PMID: 2115821
Circ Res. 1990 Aug;67(2):385-93. doi: 10.1161/01.res.67.2.385.

Experiments were designed to determine whether endothelial injury contributes to augmented coronary vascular tone seen during myocardial reperfusion. Canine left anterior descending coronary arteries were exposed to ischemia followed by reperfusion (60 minutes each). Rings (3-4 mm) of the...

Assessment of function, perfusion, metabolism, and histology in hearts preserved with University of Wisconsin solution.


Nutt MP, Fields BL, Sebree LA, Southard JH, Pyzalska D, Pyzalski R, Thomas A, Mentzer RM, Bianco JA.
PMID: 1424022
Circulation. 1992 Nov;86(5):II333-8.

BACKGROUND: University of Wisconsin solution has shown promise for prolonged cardiac preservation. This study compared the effects of 24-hour cold storage and perfusion preservation techniques by assessment of function, perfusion, metabolism, and histological changes.METHODS AND RESULTS: Three groups of...

[Hemodynamic effects of purine nucleosides in regional ischemia and reperfusion].


Selizarova NO, Eliseev VV.
PMID: 1405275
Kardiologiia. 1992 May;32(5):84-7.

The rat hearts were subjected to 60-min ischemia by left coronary artery ligation followed by 60-min reperfusion, involving intravenous adenosine inosine or guanosine given in a dose of 1 mg/kg.min-1 in the first 30 minutes of reperfusion. Ischemia and...

[Energy metabolism and contractile function of the heart in diabetic cardiomyopathy: effect of ischemia and reperfusion].

Biokhimiia (Moscow, Russia)

Dzhavadov SA, Dzhokharidze TZ, Dzhaliashvili IV, Gel'fgat EB, Saks VA, Pogacha G.
PMID: 1294259
Biokhimiia. 1992 Dec;57(12):1917-29.

Physiological parameters, rates of mitochondrial respiration, high energy phosphate levels and creatine phosphokinase (CPK) activity were investigated in the hearts from control and alloxan-induced diabetic rabbits before and after 40-min total ischemia and reperfusion. Diabetic hearts demonstrated significant decreases...

[Hibernation, stunning, ischemic preconditioning--new paradigms in coronary disease?].

Zeitschrift fur Kardiologie

Heusch G.
PMID: 1471397
Z Kardiol. 1992 Nov;81(11):596-609.

Myocardial ischemia has traditionally been characterized as an imbalance between energy supply and demand. In the initial seconds after a sudden reduction of coronary blood flow, myocardial energy demand most certainly exceeds the reduced energy supply. This temporary mismatch,...

[The effect of oxygen free radical scavenger on endothelial cell at ischemic and reperfusion injury].

[Hokkaido igaku zasshi] The Hokkaido journal of medical science

Imamura M.
PMID: 1427595
Hokkaido Igaku Zasshi. 1992 Jul;67(4):512-21.

Although a lot of investigations indicated that free radical scavengers, such as superoxide dismutase (SOD) and catalase, reduced ischemia-reperfusion injury, the precise mechanism including the sites of action are still controversial. The purposes of this study were to investigate...

Phenomenon of the adaptive stabilization of structures and protection of the heart.

The Canadian journal of cardiology

Meerson FZ, Malyshev IYu, Zamotrinsky AV.
PMID: 1486547
Can J Cardiol. 1992 Nov;8(9):965-74.

OBJECTIVE: To study the role of heat shock proteins in the mechanism of adaptive stabilization of structures.DESIGN: Double-blind randomized trial.ANIMALS: Wistar male rats weighting between 250 and 300 g.INTERVENTIONS: Adaptation to restraint stress. Animals were heparinized and anesthetized with...

Effects of recombinant human extracellular-superoxide dismutase type C on myocardial reperfusion injury in isolated cold-arrested rat hearts.

Free radical biology & medicine

Hatori N, Sjöquist PO, Marklund SL, Pehrsson SK, Rydén L.
PMID: 1516840
Free Radic Biol Med. 1992;13(2):137-42. doi: 10.1016/0891-5849(92)90075-r.

The efficacy of recombinant human extracellular-superoxide dismutase type C (EC-SOD C) on myocardial reperfusion injury was explored in hypothermically arrested rat hearts, as was its site of action. Forty isolated working rat hearts were subjected to 30 min of...

Segmental systolic responses to brief ischemia and reperfusion in the hypertrophied canine left ventricle.

Journal of the American College of Cardiology

Taylor AL, Murphree S, Buja LM, Villarreal MC, Pastor P, Eckels R.
PMID: 1388184
J Am Coll Cardiol. 1992 Oct;20(4):994-1002. doi: 10.1016/0735-1097(92)90203-y.
Free Article

OBJECTIVES AND BACKGROUND: Left ventricular hypertrophy is associated with increased mortality, increased myocardial infarct size and an increased incidence of sudden death. Although reperfusion after ischemia has been shown to result in decreased infarct size and recovery of systolic...

Showing 1 to 12 of 4661 entries