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Revealing Instability: Genetic Variation Underlies Variability in mESC Pluripotency.

Cell stem cell

D'Antonio M, D'Antonio-Chronowska A, Frazer KA.
PMID: 32888420
Cell Stem Cell. 2020 Sep 03;27(3):347-349. doi: 10.1016/j.stem.2020.08.012.

mESCs can self-renew indefinitely in vitro. However, depending on culture conditions some strains are more unstable than others. In this issue of Cell Stem Cell, Skelly et al. (2020) and Ortmann et al. (2020) shed light into the role...

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