Clinical cancer research : an official journal of the American Association for Cancer Research
Huang PS.
PMID: 22392916
Clin Cancer Res. 2012 Apr 15;18(8):2124-6. doi: 10.1158/1078-0432.CCR-12-0461. Epub 2012 Mar 05.
The rationale for using multiple inhibitors between and within the phosphoinositide 3-kinase/AKT/mTOR and RAS/MEK/ERK pathways is scientifically compelling, and a limited number of experimental agents are currently being tested in phase I combinations. Patient subpopulations, whose tumors are defined...
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Huang PS. Double down for a double win. Clin Cancer Res. 2012;18(8):2124-6doi: 10.1158/1078-0432.CCR-12-0461.
Huang, P. S. (2012). Double down for a double win. Clinical cancer research : an official journal of the American Association for Cancer Research, 18(8), 2124-6. https://doi.org/10.1158/1078-0432.CCR-12-0461
Huang, Pearl S. "Double down for a double win." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 18,8 (2012): 2124-6. doi: https://doi.org/10.1158/1078-0432.CCR-12-0461
Huang PS. Double down for a double win. Clin Cancer Res. 2012 Apr 15;18(8):2124-6. doi: 10.1158/1078-0432.CCR-12-0461. Epub 2012 Mar 05. PMID: 22392916.
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Mathematical biosciences
Pérez Millán M, Turjanski AG.
PMID: 25640872
Math Biosci. 2015 Apr;262:125-37. doi: 10.1016/j.mbs.2014.12.010. Epub 2015 Jan 30.
Mitogen-activated protein kinase (MAPK) signaling pathways play an essential role in the transduction of environmental stimuli to the nucleus, thereby regulating a variety of cellular processes, including cell proliferation, differentiation and programmed cell death. The components of the MAPK...
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Pérez Millán M, Turjanski AG. MAPK's networks and their capacity for multistationarity due to toric steady states. Math Biosci. 2015;262:125-37doi: 10.1016/j.mbs.2014.12.010.
Pérez Millán, M., & Turjanski, A. G. (2015). MAPK's networks and their capacity for multistationarity due to toric steady states. Mathematical biosciences, 262125-37. https://doi.org/10.1016/j.mbs.2014.12.010
Pérez Millán, Mercedes, and Turjanski, Adrián G. "MAPK's networks and their capacity for multistationarity due to toric steady states." Mathematical biosciences vol. 262 (2015): 125-37. doi: https://doi.org/10.1016/j.mbs.2014.12.010
Pérez Millán M, Turjanski AG. MAPK's networks and their capacity for multistationarity due to toric steady states. Math Biosci. 2015 Apr;262:125-37. doi: 10.1016/j.mbs.2014.12.010. Epub 2015 Jan 30. PMID: 25640872.
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eLife
von Itzstein MS, Drapkin BJ, Minna JD.
PMID: 34346867
Elife. 2021 Aug 04;10. doi: 10.7554/eLife.71610.
Changes in MAPK signaling allow lung cancer cells to transition between lineages that respond differently to treatment.
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von Itzstein MS, Drapkin BJ, Minna JD. How lung cancer cells change identity. Elife. 2021;10doi: 10.7554/eLife.71610.
von Itzstein, M. S., Drapkin, B. J., & Minna, J. D. (2021). How lung cancer cells change identity. eLife, 10. https://doi.org/10.7554/eLife.71610
von Itzstein, Mitchell S, et al. "How lung cancer cells change identity." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.71610
von Itzstein MS, Drapkin BJ, Minna JD. How lung cancer cells change identity. Elife. 2021 Aug 04;10. doi: 10.7554/eLife.71610. PMID: 34346867; PMCID: PMC8337071.
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Molecular cancer research : MCR
Barbosa R, Acevedo LA, Marmorstein R.
PMID: 33139506
Mol Cancer Res. 2021 Mar;19(3):361-374. doi: 10.1158/1541-7786.MCR-20-0687. Epub 2020 Nov 02.
The RAS-RAF-MEK-ERK pathway is the most well-studied of the MAPK cascades and is critical for cell proliferation, differentiation, and survival. Abnormalities in regulation resulting from mutations in components of this pathway, particularly in upstream proteins, RAS and RAF, are...
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Barbosa R, Acevedo LA, Marmorstein R. The MEK/ERK Network as a Therapeutic Target in Human Cancer. Mol Cancer Res. 2020;19(3):361-374doi: 10.1158/1541-7786.MCR-20-0687.
Barbosa, R., Acevedo, L. A., & Marmorstein, R. (2021). The MEK/ERK Network as a Therapeutic Target in Human Cancer. Molecular cancer research : MCR, 19(3), 361-374. https://doi.org/10.1158/1541-7786.MCR-20-0687
Barbosa, Renee, et al. "The MEK/ERK Network as a Therapeutic Target in Human Cancer." Molecular cancer research : MCR vol. 19,3 (2021): 361-374. doi: https://doi.org/10.1158/1541-7786.MCR-20-0687
Barbosa R, Acevedo LA, Marmorstein R. The MEK/ERK Network as a Therapeutic Target in Human Cancer. Mol Cancer Res. 2021 Mar;19(3):361-374. doi: 10.1158/1541-7786.MCR-20-0687. Epub 2020 Nov 02. PMID: 33139506; PMCID: PMC7925338.
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Cancer cell
Hey F, Pritchard C.
PMID: 23680140
Cancer Cell. 2013 May 13;23(5):561-3. doi: 10.1016/j.ccr.2013.04.021.
ERK pathway activation in cells expressing wild-type BRAF is a well-reported, clinically-relevant adverse effect of the otherwise impressive response of BRAF(V600E)-mutated melanomas to RAF inhibitors. In this issue of Cancer Cell, Holderfield and colleagues show that RAF autoinhibition underpins...
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Hey F, Pritchard C. A new mode of RAF autoregulation: a further complication in the inhibitor paradox. Cancer Cell. 2013;23(5):561-3doi: 10.1016/j.ccr.2013.04.021.
Hey, F., & Pritchard, C. (2013). A new mode of RAF autoregulation: a further complication in the inhibitor paradox. Cancer cell, 23(5), 561-3. https://doi.org/10.1016/j.ccr.2013.04.021
Hey, Fiona, and Pritchard, Catrin. "A new mode of RAF autoregulation: a further complication in the inhibitor paradox." Cancer cell vol. 23,5 (2013): 561-3. doi: https://doi.org/10.1016/j.ccr.2013.04.021
Hey F, Pritchard C. A new mode of RAF autoregulation: a further complication in the inhibitor paradox. Cancer Cell. 2013 May 13;23(5):561-3. doi: 10.1016/j.ccr.2013.04.021. PMID: 23680140.
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