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Hormonal regulation of pituitary GH3 cell K+ channels by Gk is mediated by its alpha-subunit.

Codina J, Grenet D, Yatani A, Birnbaumer L, Brown AM.
PMID: 2438161
FEBS Lett. 1987 May 25;216(1):104-6. doi: 10.1016/0014-5793(87)80765-2.
Free Article

The resolved alpha-GTP gamma S (alpha*) and beta gamma-subunits of human erythrocyte Gk, the stimulatory regulatory component of hormone-responsive K+ channels, were tested for their potential stimulatory activities on the K+ channel of the endocrine GH3 cell. Concentrations as...

Ethanol inhibits NMDA-activated ion current in hippocampal neurons.

Lovinger DM, White G, Weight FF.
PMID: 2467382
Science. 1989 Mar 31;243(4899):1721-4. doi: 10.1126/science.2467382.

The ion current induced by the glutamate receptor agonist N-methyl-D-aspartate (NMDA) in voltage-clamped hippocampal neurons was inhibited by ethanol (EtOH). Inhibition increased in a concentration-dependent manner over the range 5 to 50 mM, a range that also produces intoxication....

Comparison of the calcium requirement for the induction and maintenance of B cell class II molecule expression and for B cell proliferation stimulated by mitogens and purified growth factors.

Dennis GJ, Mizuguchi J, McMillan V, Finkelman FD, Ohara J, Mond JJ.
PMID: 2438339
J Immunol. 1987 Jun 15;138(12):4307-12.

As an important intracellular second-messenger, the concentration of calcium in the cytosol [Ca+2]i influences diverse cellular activities. To investigate the calcium requirement for distinct phases of B cell activation, we studied the effect of altering the quantity of extracellular...

Differential effects of the K+ channel blockers apamin and quinine on glucose-induced electrical activity in pancreatic beta-cells from a strain of ob/ob (obese) mice.

Rosario LM.
PMID: 2411599
FEBS Lett. 1985 Sep 02;188(2):302-6. doi: 10.1016/0014-5793(85)80391-4.
Free Article

The effects of apamin and quinine on glucose-induced electrical activity in pancreatic islets from ob/ob mice (Norwich colony) were compared. Apamin (40-400 nM) increased the duration of the bursts of electrical activity, whereas quinine (50-100 microM) affected only slightly...

Possible role of Na+ ions in intracellular Ca2+ release in frog auricular trabeculae.

Bonvallet R, Christé G, Ildefonse M, Rougier O.
PMID: 2411628
Gen Physiol Biophys. 1985 Apr;4(2):167-83.

Membrane potential-current and mechanical tension of frog atrial muscle were studied in a Ca and Mg-free solution containing 1 mmol/l EGTA (Ca-free solution). Exposure to Ca-free solution resulted in a shortening of action potential duration within 1.5 min and...

The channel-forming component of the Theridiidae spider venom neurotoxins.

Usmanov PB, Kazakov I, Kalikulov D, Atakuziev BU, Yukelson LYa, Tashmukhamedov BA.
PMID: 2411629
Gen Physiol Biophys. 1985 Apr;4(2):185-93.

It is known that Steatoda (Lityphantes) paykulliana and Latrodectus mactans tredecimguttatus spider venoms are toxic to mammals and insects. These venoms act presynaptically eliciting massive release of transmitters. They also form channels in bilayer lipid membranes (BLM) that are...

Relationship between cell volume and ion transport in the early distal tubule of the Amphiuma kidney.

Guggino WB, Oberleithner H, Giebisch G.
PMID: 2411847
J Gen Physiol. 1985 Jul;86(1):31-58. doi: 10.1085/jgp.86.1.31.
Free PMC Article

The roles of apical and basolateral transport mechanisms in the regulation of cell volume and the hydraulic water permeabilities (Lp) of the individual cell membranes of the Amphiuma early distal tubule (diluting segment) were evaluated using video and optical...

A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: a nonlethal selective alteration in calmodulin regulation.

Schaefer WH, Hinrichsen RD, Burgess-Cassler A, Kung C, Blair IA, Watterson DM.
PMID: 2438688
Proc Natl Acad Sci U S A. 1987 Jun;84(11):3931-5. doi: 10.1073/pnas.84.11.3931.
Free PMC Article

The Paramecium mutant, pantophobiac A, has a defect that results in an in vivo loss of calcium-dependent potassium efflux channel activity. This defect is corrected fully by the microinjection of wild-type Paramecium calmodulin into pantophobiac A cells and is...

Role of reactive oxygen species in reperfusion injury of the rabbit lung.

Kennedy TP, Rao NV, Hopkins C, Pennington L, Tolley E, Hoidal JR.
PMID: 2467923
J Clin Invest. 1989 Apr;83(4):1326-35. doi: 10.1172/JCI114019.
Free PMC Article

We have developed a model of reperfusion injury in Krebs buffer-perfused rabbit lungs, characterized by pulmonary vasoconstriction, microvascular injury, and marked lung edema formation. During reperfusion there was a threefold increase in lung superoxide anion (O2-) production, as measured...

Blockage of the sodium current in isolated single cells from rat ventricle with mexiletine and disopyramide.

Yatani A, Akaike N.
PMID: 2411942
J Mol Cell Cardiol. 1985 May;17(5):467-76. doi: 10.1016/s0022-2828(85)80051-1.

The blocking effects of local anesthetics, mexiletine and disopyramide on the sodium currents (INa) of enzymatically isolated, single cells from rat ventricle were studied under voltage clamp conditions. A suction pipette technique was used for voltage clamp and internal...

Calcium channels are 'unblocked' within a few milliseconds after photoremoval of nifedipine.

Nerbonne JM, Richard S, Nargeot J.
PMID: 2411944
J Mol Cell Cardiol. 1985 May;17(5):511-5. doi: 10.1016/s0022-2828(85)80056-0.

The organic Ca2+ antagonists are potent inhibitors of Ca2+ influx in cardiac and smooth muscle and are widely used clinically in the treatment of various cardiovascular disorders. It appears that Ca2+ antagonist binding prevents the normal movement of ions...

Effects of abscisic acid on K+ channels in Vicia faba guard cell protoplasts.

Schauf CL, Wilson KJ.
PMID: 2439078
Biochem Biophys Res Commun. 1987 May 29;145(1):284-90. doi: 10.1016/0006-291x(87)91318-0.

Potassium channels were resolved in Vicia faba guard cell protoplasts by patch voltage-clamp. Whole-cell currents and single K+ channels had linear instantaneous current-voltage relations, reversing at the calculated Nernst potential for K+. Whole cell K+ currents activated exponentially during...

Showing 1 to 12 of 8711 entries