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Insulin and insulin-like growth factors stimulate in vivo receptor autophosphorylation and tyrosine phosphorylation of a 70K substrate in cultured fetal chick neurons.


Kenner KA, Heidenreich KA.
PMID: 1711464
Endocrinology. 1991 Jul;129(1):301-11. doi: 10.1210/endo-129-1-301.

Insulin and insulin-like growth factors (IGFs) have been shown to regulate neuronal growth and differentiation. To investigate the possible role of tyrosine phosphorylation in the neurotrophic actions of these peptides, we examined the effects of insulin, IGF-I, and IGF-II...

Insulin-like growth factor II may play a local role in the regulation of ocular size.

Development (Cambridge, England)

Cuthbertson RA, Beck F, Senior PV, Haralambidis J, Penschow JD, Coghlan JP.
PMID: 2560708
Development. 1989 Sep;107(1):123-30.

The ultimate size and shape of the eye has a profound influence on its refraction and function. However, the role of growth factors in normal ocular development is poorly understood. Insulin-like growth factors IGF-I and -II have major effects...

Fetal lung fibroblasts secrete and respond to insulin-like growth factors.

American journal of respiratory cell and molecular biology

Daughaday WH.
PMID: 2560394
Am J Respir Cell Mol Biol. 1989 Jul;1(1):11-2. doi: 10.1165/ajrcmb/1.1.11.

No abstract available.

Rat somatotroph insulin-like growth factor-II (IGF-II) signaling: role of the IGF-I receptor.


Weber MM, Melmed S, Rosenbloom J, Yamasaki H, Prager D.
PMID: 1425415
Endocrinology. 1992 Nov;131(5):2147-53. doi: 10.1210/endo.131.5.1425415.

The anterior pituitary contains insulin-like growth factor-II (IGF-II) and expresses abundant IGF-II-binding sites, but the IGF-II signaling pathway in the pituitary has not been defined. We, therefore, tested the effects of recombinant human IGF-II on pituitary function by assessing...

Insulin-like growth factor II gene expression in human neuroblastoma.

Progress in clinical and biological research

el-Badry OM.
PMID: 2068141
Prog Clin Biol Res. 1991;366:249-56.

No abstract available.

[Recent findings on the etiopathogenesis of multinodular goiter. II. Thyroid growth factors].

Chirurgia italiana

Francia G, Musumeci C, Daví MV, Azzolina LS, Zamboni G, Sussi PL.
PMID: 1782708
Chir Ital. 1991 Jun-Aug;43(3):84-9.

In the last ten years several experimental data have suggested that growth factors may play an important role in modulating thyroid growth and function. Epidermal Growth Factor (EGF) is present in large quantities in thyroid tissue, where it appears...

Insulin-like growth factors and their receptors in muscle development.

Advances in experimental medicine and biology

Szebenyi G, Rotwein P.
PMID: 1722618
Adv Exp Med Biol. 1991;293:289-95. doi: 10.1007/978-1-4684-5949-4_26.

Several proteins involved in IGF action are expressed in C2 cells and their abundance was found to vary as a function of development. IGF-I and II mRNA levels rose 10 and 25-fold, respectively, during differentiation, and were accompanied by...

Somatomedins and growth.

Acta clinica Belgica

De Vroede M.
PMID: 3071061
Acta Clin Belg. 1988;43(6):407-10. doi: 10.1080/17843286.1988.11717967.

No abstract available.

IGF-I and IGF-II expression in human breast cancer xenografts: relationship to hormone independence.

Breast cancer research and treatment

Brünner N, Moser C, Clarke R, Cullen K.
PMID: 1421423
Breast Cancer Res Treat. 1992;22(1):39-45. doi: 10.1007/BF01833332.

Although the growth of some estrogen receptor (ER) positive breast cancers can initially be hormonally manipulated, all will eventually escape hormonal control. It is possible that the expression of polypeptide growth factors is initially under the control of steroid...

Potential role of HBGF (FGF) and TGF-beta on prostate growth.

Advances in experimental medicine and biology

Matuo Y, McKeehan WL, Yan GC, Nikolaropoulos S, Adams PS, Fukabori Y, Yamanaka H, Gaudreau J.
PMID: 1492611
Adv Exp Med Biol. 1992;324:107-14. doi: 10.1007/978-1-4615-3398-6_11.

We review in this paper the role of heparin-binding growth factor (HBGF*) or fibroblast growth factor (FGF*), rat prostate cancer cells produce TGF-beta, IGF-II* and OGF*. Of these growth factors, TGF-beta and unknown labile factor with 19 kDa are...

Insulin-like growth factor II overexpression does not affect sorting of lysosomal enzymes in NIH-3T3 cells.

Biochemical and biophysical research communications

Braulke T, Bresciani R, Buergisser DM, von Figura K.
PMID: 1679327
Biochem Biophys Res Commun. 1991 Aug 30;179(1):108-15. doi: 10.1016/0006-291x(91)91341-9.

The sorting of newly synthesized mannose 6-phosphate (M6P)-containing proteins and of the major excreted protein (MEP), a lysosomal thiol proteinase, was studied in NIH-3T3 cells transfected with the cDNA of human insulin-like growth factor II (IGF II) or with...

Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II.

Molecular endocrinology (Baltimore, Md.)

Papa V, Hartmann KK, Rosenthal SM, Maddux BA, Siiteri PK, Goldfine ID.
PMID: 1649393
Mol Endocrinol. 1991 May;5(5):709-17. doi: 10.1210/mend-5-5-709.

Insulin-like growth factor-I (IGF-I) receptors are present in breast cancer cells and may play a role in breast cancer cell growth. We have studied the effect of progestins on IGF-I receptors in T47D human breast cancer cells. T47D cells...

Showing 1 to 12 of 580 entries