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Structure and evolution of insulin and insulin-like growth factors in chordates.

Progress in brain research

Chan SJ, Nagamatsu S, Cao QP, Steiner DF.
PMID: 1302874
Prog Brain Res. 1992;92:15-24. doi: 10.1016/s0079-6123(08)61161-9.

No abstract available.

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.

Genes & development

Rappolee DA, Sturm KS, Behrendtsen O, Schultz GA, Pedersen RA, Werb Z.
PMID: 1317321
Genes Dev. 1992 Jun;6(6):939-52. doi: 10.1101/gad.6.6.939.
Free Article

We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages. mRNA and protein for IGF-II were expressed in preimplantation mouse embryos,...

Transfected insulin-like growth factor II modulates the mitogenic response of rat thyrocytes in culture.

Molecular and cellular endocrinology

Veneziani BM, Di Marino C, Salvatore P, Villone G, Perrotti N, Frunzio R, Tramontano D.
PMID: 1511776
Mol Cell Endocrinol. 1992 Jul;86(1):11-20. doi: 10.1016/0303-7207(92)90170-b.

Rat thyroid cells (FRTL5), transfected with the sequence coding for rat insulin-like growth factor II (IGF-II) presented mRNA specific for the transfected IGF-II in most of the clones obtained (Tr clones). Tr7 and Tr12 cells maintained their ability to...

Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus.


Forejt J, Gregorová S.
PMID: 1322799
Cell. 1992 Aug 07;70(3):443-50. doi: 10.1016/0092-8674(92)90168-c.

The Thp deletion on mouse chromosome 17 is lethal when inherited from the mother, because it deletes the T-associated maternal effect (Tme) locus, the paternal copy of which is inactivated by genomic imprinting. We have found a paternally nonimprinted...

RFLPs for somatotropic genes identify quantitative trait loci for growth in mice.


Winkelman DC, Hodgetts RB.
PMID: 1355456
Genetics. 1992 Aug;131(4):929-37. doi: 10.1093/genetics/131.4.929.
Free PMC Article

Restriction fragment length polymorphisms for somatotropic genes were tested for associations with body weight and postweaning growth rate in mice. Polymorphisms for growth hormone (GH) and insulin-like growth factor 2 (IGF-2) genes were identified in stock population lines which...

Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines.

Brain research. Molecular brain research

Martin DM, Yee D, Carlson RO, Feldman EL.
PMID: 1331680
Brain Res Mol Brain Res. 1992 Oct;15(3):241-6. doi: 10.1016/0169-328x(92)90114-q.

Insulin-like growth factors (IGF) I and II are polypeptides with both growth-promoting and insulin-like metabolic effects. The developmentally specific expression of IGF I and II in the nervous system implies a role for these growth factors in neuronal growth...

Imprinting and Beckwith-Wiedemann syndrome.

Lancet (London, England)

Hoovers JM, Dietrich AJ, Mannens MM.
PMID: 1349953
Lancet. 1992 May 16;339(8803):1228. doi: 10.1016/0140-6736(92)91164-4.

No abstract available.

Pattern of growth factor, proto-oncogene and carcinoembryonic antigen gene expression in human colorectal carcinoma cell lines.


La Rocca RV, Park JG, Danesi R, Del Tacca M, Steinberg SM, Gazdar AF.
PMID: 1495747
Oncology. 1992;49(3):209-14. doi: 10.1159/000227040.

The aim of the present study was to examine whether the expression of growth factor genes, proto-oncogenes and carcinoembryonic antigen (CEA) gene in human colorectal cancer cell lines was related to their clinicobiological behavior. A significant variability among cell...

Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene.

Nucleic acids research

Meinsma D, Scheper W, Holthuizen PE, Van den Brande JL, Sussenbach JS.
PMID: 1408818
Nucleic Acids Res. 1992 Oct 11;20(19):5003-9. doi: 10.1093/nar/20.19.5003.
Free PMC Article

The human insulin-like growth factor II (IGF-II) gene constitutes a complex transcriptional unit that contains nine exons and four promoters. Expression of the IGF-II gene yields a family of mRNAs that all encode prepro-IGF-II. In addition, a stable 1.8...

Abnormal regulation of insulin-like growth factor gene expression in peripheral blood mononuclear cells from patients with IgA nephropathy.

American journal of nephrology

Nakamura T, Ebihara I, Nagaoka I, Takahashi T, Tomino Y, Koide H.
PMID: 1283288
Am J Nephrol. 1992;12(5):292-302. doi: 10.1159/000168463.

We investigated insulin-like growth factor (IGF)-I and -II mRNA expression in peripheral blood mononuclear cells (PBMC) and T cells obtained from 31 patients with IgA nephropathy (IgAN), 43 patients with other types of glomerulonephritis and 16 health age-matched controls....

Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor.

DNA (Mary Ann Liebert, Inc.)

Stempien MM, Fong NM, Rall LB, Bell GI.
PMID: 3780370
DNA. 1986 Oct;5(5):357-61. doi: 10.1089/dna.1986.5.357.

cDNAs encoding the mouse insulin-like growth factor II (IGF-II) precursor have been isolated from a placental library and sequenced. Mouse prepro-IGF-II is predicted to be 180 amino acids and has 84% and 97% identity with human and rat IGF-II...

Expression of a human insulin-like growth factor II cDNA in NIH-3T3 cells.

Biochemical and biophysical research communications

Buergisser DM, Roth BV, Luethi C, Gerber HP, Honegger A, Humbel RE.
PMID: 2363726
Biochem Biophys Res Commun. 1990 Jun 29;169(3):832-9. doi: 10.1016/0006-291x(90)91968-x.

Recombinant human insulin-like growth factor II (IGF-II) was produced in NIH-3T3 cells transfected with a plasmid containing a construct encoding the signal peptide and the sequence of mature human IGF II. Successfully transfected clones secreted correctly processed recombinant human...

Showing 1 to 12 of 3062 entries