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Renal hemodynamics in canine DOCA-salt hypertension: effect of calcium channel blockade.

The Tohoku journal of experimental medicine

Zimmerman BG, Raich PC.
PMID: 1357781
Tohoku J Exp Med. 1992 Jan;166(1):147-54. doi: 10.1620/tjem.166.147.
Free Article

Systemic arterial blood pressure (BP), renal blood flow (RBF), and renal vascular resistance (RVR) were followed for 3-4 wks during the progression of DOCA-salt hypertension in the conscious dog. Accompanying the gradual increase in BP was an increase in...

Role of the adrenal medulla in stress-induced hyperinsulinaemia in normal mice and in mice infected with Bordetella pertussis or treated with pertussis toxin.

The Journal of endocrinology

Sidey FM, Dean HG, Furman BL.
PMID: 3045244
J Endocrinol. 1988 Jul;118(1):135-40. doi: 10.1677/joe.0.1180135.

Intranasal infection of mice with a sublethal dose of Bordetella pertussis or the intravenous administration of purified pertussis toxin resulted in a marked increase in the serum immunoreactive insulin concentration following ether stress. This stress-induced hyperinsulinaemia was not modified...

Alpha 2-adrenoceptor antagonists block the stimulant effects of cocaine in mice.

Life sciences

Jackson HC, Griffin IJ, Nutt DJ.
PMID: 1349416
Life Sci. 1992;50(19):PL155-9. doi: 10.1016/0024-3205(92)90267-s.

In the present study we have investigated the effects of the alpha 2-adrenoceptor antagonist idazoxan and its 2-ethoxy derivative RX811059 on the locomotor activity induced by cocaine in mice. The stimulant effects of cocaine (15 mg/kg i.p.) were significantly...

Pertussis toxin blocks the effects of alpha 2-agonists and antagonists on locus coeruleus activity in vivo.

Neuroscience letters

Simson PE, Cierpial MA, Heyneman LE, Weiss JM.
PMID: 2901703
Neurosci Lett. 1988 Jul 08;89(3):361-6. doi: 10.1016/0304-3940(88)90553-8.

This study assessed the effects of pertussis toxin, which is known to inactivate G proteins and therefore to block receptors linked to G proteins, on electrophysiological activity of the locus coeruleus in vivo. Pertussis toxin was injected into the...

Central and peripheral effects of prostaglandin E2 and enprostil on gastric acid secretion in the rat.

European journal of pharmacology

Sautereau D, Chicau-Chovet M, Tsocas A, Rozé C.
PMID: 1678708
Eur J Pharmacol. 1991 Mar 26;195(2):217-24. doi: 10.1016/0014-2999(91)90538-2.

The intracerebroventricular (i.c.v.) administration of prostaglandin E2 (PGE2) inhibits gastric secretion at doses that are inactive by i.v. administration in the rat. The present study was undertaken to examine the central and peripheral effects of enprostil, a potent synthetic...

Noradrenaline sensitivity and calcium fluxes in arteries from rabbits with perinephritis hypertension.

Clinical and experimental pharmacology & physiology

Hall MT, Wadsworth RM, Kane KA, Hamilton CA, Reid JL, Rodger IW.
PMID: 2208798
Clin Exp Pharmacol Physiol. 1990 Aug;17(8):531-43. doi: 10.1111/j.1440-1681.1990.tb01354.x.

1. Contractions of isolated vascular and cardiac preparations taken from rabbits with perinephritis (one kidney, one wrapped) hypertension were compared with those of preparations from control operated animals. 2. Significantly increased sensitivity to noradrenaline, which acts on alpha 1-adrenoceptors,...

Modulation of noradrenaline release in slices of rat kidney cortex through alpha 1- and alpha 2-adrenoceptors.

European journal of pharmacology

Murphy TV, Majewski H.
PMID: 2553450
Eur J Pharmacol. 1989 Oct 10;169(2):285-95. doi: 10.1016/0014-2999(89)90026-5.

Slices of rat kidney cortex were incubated in [3H]noradrenaline, then placed in a flow cell and subjected to electrical field stimulation. At a stimulation frequency of 5 Hz, both the alpha 2-adrenoceptor antagonist idazoxan (0.1 microM) and the alpha...

An alpha 2 antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus.

Brain research

Richter-Levin G, Segal M, Sara S.
PMID: 1675916
Brain Res. 1991 Feb 01;540(1):291-4. doi: 10.1016/0006-8993(91)90521-v.

The effect of the alpha 2 antagonist, idazoxan (IDA), on the excitability of neurons in the dentate gyrus of the hippocampus was studied. Population field potentials (PS) evoked by stimulation of the perforant pathway were measured before and after...

Antidiuretic effect of bremazocine and U-50,488 in rats after alpha 2-adrenoceptor blockade.

The Journal of pharmacy and pharmacology

Bianchi G.
PMID: 1675283
J Pharm Pharmacol. 1991 Mar;43(3):212-6. doi: 10.1111/j.2042-7158.1991.tb06670.x.

The role of alpha 2-adrenoceptors and kappa-opioid receptors in urination was studied in rats. In water-loaded rats (40 mL kg-1 p.o.) the kappa-opioid agonist bremazocine (0.05 0.2 mg kg-1 i.p.) induced a dose-related diuretic response in the second hour...

The role of imidazoline receptors in blood pressure regulation.

Pharmacology & therapeutics

Hamilton CA.
PMID: 1361236
Pharmacol Ther. 1992;54(3):231-48. doi: 10.1016/0163-7258(92)90001-g.

Using the ligands [3H] clonidine and [3H] idazoxan, nonadrenergic imidazoline preferring binding sites have been identified in a range of tissues from several species including man. These sites may represent a new family of receptors. An endogenous ligand and...

Evidence for the involvement of alpha 1-adrenoceptors in negative feedback regulation of noradrenergic transmitter release in rat atria.

Clinical science (London, England : 1979)

Story DF, Standford-Starr CA, Rand MJ.
PMID: 2857604
Clin Sci (Lond). 1985;68:111s-115s. doi: 10.1042/cs068s111.

Experiments were undertaken to determine if prejunctional alpha 1-adrenoceptors are involved in autoinhibitory regulation of transmitter noradrenaline release in rat atria. The noradrenergic transmitter stores in rat isolated atria were radiolabelled with [3H]noradrenaline and transmitter release was deduced from...

Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain.

The Journal of pharmacology and experimental therapeutics

Boyajian CL, Loughlin SE, Leslie FM.
PMID: 3037066
J Pharmacol Exp Ther. 1987 Jun;241(3):1079-91.

Previous autoradiographic studies which have localized alpha-2 adrenoceptors within brain have used tritiated derivatives of clonidine and other alpha-2 adrenergic agonists. In the present study we have compared the autoradiographic distributions of binding sites labeled by two reportedly selective...

Showing 1 to 12 of 1437 entries