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Showing 1 to 5 of 5 entries
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Finding alternative expression quantitative trait loci by exploring sparse model space.

Journal of computational biology : a journal of computational molecular cell biology

Wang Z, Xu J, Shi X.
PMID: 24689773
J Comput Biol. 2014 May;21(5):385-93. doi: 10.1089/cmb.2014.0026. Epub 2014 Apr 01.

Sparse modeling, a feature selection method widely used in the machine-learning community, has been recently applied to identify associations in genetic studies including expression quantitative trait locus (eQTL) mapping. These genetic studies usually involve high dimensional data where the...

miRNAs in atherosclerotic plaque initiation, progression, and rupture.

Trends in molecular medicine

Andreou I, Sun X, Stone PH, Edelman ER, Feinberg MW.
PMID: 25771097
Trends Mol Med. 2015 May;21(5):307-18. doi: 10.1016/j.molmed.2015.02.003. Epub 2015 Mar 11.

Atherosclerosis is a chronic immune-inflammatory disorder that integrates multiple cell types and a diverse set of inflammatory mediators. miRNAs are emerging as important post-transcriptional regulators of gene expression in most, if not all, vertebrate cells, and constitute central players...

Integrated multifactor analysis explores core dysfunctional modules in autism spectrum disorder.

International journal of biological sciences

Huang Y, Chang Z, Li X, Liang S, Yi Y, Wu L.
PMID: 29989084
Int J Biol Sci. 2018 May 22;14(8):811-818. doi: 10.7150/ijbs.24624. eCollection 2018.

Autism spectrum disorder (ASD) is a complex neurodevelopmental disease in early childhood, and growing up to be a major cause of disability in children. However, the underlying molecular mechanism of ASD remains elusive. Hence, we represented integrated multifactor analysis...

Black Swans of CRISPR: Stochasticity and Complexity of Genetic Regulation.

BioEssays : news and reviews in molecular, cellular and developmental biology

Cheong KH, Koh JM, Jones MC.
PMID: 31090950
Bioessays. 2019 Jul;41(7):e1900032. doi: 10.1002/bies.201900032. Epub 2019 May 15.

Recent waves of controversies surrounding genetic engineering have spilled into popular science in Twitter battles between reputable scientists and their followers. Here, a cautionary perspective on the possible blind spots and risks of CRISPR and related biotechnologies is presented,...

Editorial overview: Diving into the Genome.

Current opinion in genetics & development

Bystricky K, Merkenschlager M.
PMID: 32950132
Curr Opin Genet Dev. 2020 Apr;61:iii-vi. doi: 10.1016/j.gde.2020.06.001.

No abstract available.

Showing 1 to 5 of 5 entries