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Showing 1 to 12 of 13058 entries
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Epidermal growth factor and 12-tetradecanoyl phorbol 13-acetate induction of urokinase in A431 cells.

Seminars in thrombosis and hemostasis

Kessler TL, Markus G.
PMID: 1796295
Semin Thromb Hemost. 1991 Jul;17(3):217-24. doi: 10.1055/s-2007-1002612.

The signal transduction pathways of urokinase (u-PA) in A431 cells, a human epidermoid carcinoma cell line, were studied using the inducers EGF and TPA. Based on the following observations, we conclude that the two pathways are different: (1) The...

Effects of inducers of drug metabolism on basic hepatic forms of mouse glutathione transferase.

The Biochemical journal

Di Simplicio P, Jensson H, Mannervik B.
PMID: 2597126
Biochem J. 1989 Nov 01;263(3):679-85. doi: 10.1042/bj2630679.
Free PMC Article

The cytosolic glutathione transferases (GSTs) with basic pI values have been studied in mouse liver after treatment with 2,3-t-butylhydroxyanisole (BHA), cafestol palmitate (CAF), phenobarbital (PB), 3-methylcholanthrene (3-MC) and trans-stilbene oxide (t-SBO). The cytosolic GST activity was induced by all...

Induction of cytochromes P-450b/e by phenobarbital in primary culture of adult rat hepatocytes: test of differentiated liver gene expression.

Drug metabolism reviews

Guzelian PS, Li D, Schuetz EG.
PMID: 2806079
Drug Metab Rev. 1989;20(2):793-809. doi: 10.3109/03602538909103579.

No abstract available.

Growth hormone regulation of the cytochrome P-450IIC subfamily in the rat: inductive, repressive, and transcriptional effects on P-450f (IIC7) and P-450PB1 (IIC6) gene expression.

Molecular pharmacology

Westin S, Ström A, Gustafsson JA, Zaphiropoulos PG.
PMID: 2385231
Mol Pharmacol. 1990 Aug;38(2):192-7.

The effects of growth hormone (GH) on two constitutively expressed rat liver cytochrome P-450 (P-450) enzymes, namely P-450f (IIC7) and P-450PB1 (IIC6), have been investigated. Hypophysectomy of both male and female rats results in low expression of P-450f. Single...

Comparison of beta-galactosidase production by two inducible promoters in Myxococcus xanthus.

Research in microbiology

Letouvet-Pawlak B, Monnier C, Barray S, Hodgson DA, Guespin-Michel JF.
PMID: 2119047
Res Microbiol. 1990 May;141(4):425-35. doi: 10.1016/0923-2508(90)90069-3.

The inducibility of two promoter systems, one heterologous and one homologous, has been assessed in the Gram-negative bacterium Myxococcus xanthus. The heterologous system involved the hybrid tac promoter and the presence of lacIq, the lac repressor from Escherichia coli....

Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices.

Brain research

Pai KS, Ravindranath V.
PMID: 1933335
Brain Res. 1991 Aug 02;555(2):239-44. doi: 10.1016/0006-8993(91)90347-x.

Exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes loss of dopaminergic neurons in humans, primates and mice. Exposure of sagittal slices of mouse brain to MPTP (100 pM) caused inhibition of mitochondrial NADH-dehydrogenase activity. Leakage of lactate dehydrogenase from the slice into...

Induction of beta-lactamase in Gram-negative bacteria.

Diagnostic microbiology and infectious disease

Wiedemann B, Peter K.
PMID: 2686915
Diagn Microbiol Infect Dis. 1989 Jul-Aug;12(4):131S-137S. doi: 10.1016/0732-8893(89)90125-9.

The induction of beta-lactamase in Gram-negative bacteria in vitro has been established. It is possible to distinguish between high and low beta-lactamase inducers in vitro. This differentiation is clinically irrelevant because induction has little effect on the treatment of...

Biotransformation in carcinogen-induced diploid and polyploid hepatocytes separated by centrifugal elutriation.

Cancer research

Watkins JB, Thierau D, Schwarz LR.
PMID: 1737374
Cancer Res. 1992 Mar 01;52(5):1149-54.
Free Article

Biotransformation in carcinogen-induced diploid and polyploid hepatocytes was studied using isozyme-selective substrates for several enzyme pathways. Diploid hepatocytes were induced by partial hepatectomy, a single injection of diethylnitrosamine, and 4 weeks of 2-acetylaminofluorene (2-AAF) feeding. Then, after an additional...

Induction of renin activity by gonadotropic hormones in cultured Leydig tumor cells.

Endocrinology

Pandey KN, Ascoli M, Inagami T.
PMID: 2412804
Endocrinology. 1985 Nov;117(5):2120-6. doi: 10.1210/endo-117-5-2120.

The hormonal regulation of renin activity in cloned and cultured Leydig tumor cells (designated MA-10) was examined. The treatment of Leydig cell cultures with bovine LH (bLH), hCG, or with (Bu)2cAMP elicited a dose- and time-dependent induction of renin...

Transient induction of single GST-P positive hepatocytes by DEN.

Carcinogenesis

Satoh K, Hatayama I, Tateoka N, Tamai K, Shimizu T, Tatematsu M, Ito N, Sato K.
PMID: 2805231
Carcinogenesis. 1989 Nov;10(11):2107-11. doi: 10.1093/carcin/10.11.2107.

The single cells positive for placental glutathione S-transferase (GST-P), detectable in livers of rats soon after treatment with hepatocarcinogens, are possible 'initiated cells', the hypothesis tested in the present series of experiments. No low dose threshold was observed in...

Histidine decarboxylase in human basophilic leukemia (KU-812-F) cells. Characterization and induction by phorbol myristate acetate.

Biochemical pharmacology

Mamune-Sato R, Tanno Y, Maeyama K, Miura Y, Takishima T, Kishi K, Fukuda T, Watanabe T.
PMID: 2117926
Biochem Pharmacol. 1990 Sep 01;40(5):1125-9. doi: 10.1016/0006-2952(90)90502-c.

The human leukemic cell line KU-812-F is known to differentiate into mature basophil-like cells under serum-free culture conditions. In the present study, the activity of histidine decarboxylase (HDC), a histamine-forming enzyme, in KU-812-F cells was found to be high,...

Metabolism of 7,12-dimethylbenz[a]anthracene in hepatic microsomal membranes from rats treated with isoenzyme-selective inducers of cytochromes P450.

Biochemical pharmacology

Morrison VM, Burnett AK, Craft JA.
PMID: 1902108
Biochem Pharmacol. 1991 May 15;41(10):1505-12. doi: 10.1016/0006-2952(91)90568-p.

Previous work has shown that member(s) of the cytochrome P450IIC sub-family play significant roles in the formation of diols of 7,12-dimethylbenz[a]anthracene (DMBA) and are particularly important in formation of the proximate carcinogen (DMBA-3,4-diol). To further characterize the role of...

Showing 1 to 12 of 13058 entries