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Showing 1 to 12 of 14 entries
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Logical comparison over RDF resources in bio-informatics.

Journal of biomedical informatics

Colucci S, Donini FM, Di Sciascio E.
PMID: 29127041
J Biomed Inform. 2017 Dec;76:87-101. doi: 10.1016/j.jbi.2017.11.004. Epub 2017 Nov 07.

Comparison of resources is a frequent task in different bio-informatics applications, including drug-target interaction, drug repositioning and mechanism of action understanding, among others. This paper proposes a general method for the logical comparison of resources modeled in Resource Description...

Microdosing and Other Phase 0 Clinical Trials: Facilitating Translation in Drug Development.

Clinical and translational science

Burt T, Yoshida K, Lappin G, Vuong L, John C, de Wildt SN, Sugiyama Y, Rowland M.
PMID: 26918865
Clin Transl Sci. 2016 Apr;9(2):74-88. doi: 10.1111/cts.12390. Epub 2016 Mar 30.

A number of drivers and developments suggest that microdosing and other phase 0 applications will experience increased utilization in the near-to-medium future. Increasing costs of drug development and ethical concerns about the risks of exposing humans and animals to...

Smoking and drug interactions.

American journal of public health

Schein J.
PMID: 8203676
Am J Public Health. 1994 Jun;84(6):1034. doi: 10.2105/ajph.84.6.1034.
Free PMC Article

No abstract available.

Drug interactions of new antiretroviral drugs.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

Serrano López de Las Hazas JI.
PMID: 21208819
Farm Hosp. 2011 Jan-Feb;35(1):36-43. doi: 10.1016/j.farma.2010.01.018. Epub 2011 Jan 03.

A systematic review was made of the drug interactions of new antiretroviral drugs. In order to do this a search was made in Pubmed to find articles published from January 2007 to September 2009 and the full-text articles which...

Development of a high-speed, multiplexed sample-delivery instrument for LC-MS/MS bioanalysis.

Bioanalysis

Janiszewski J, Schneider R, Kapinos B, West M, Funk C, Federico J, Umland J, Piotrowski M, Mitchell W, Zhang H, Zelesky V, Gobey J, Whalen K, Liston T, Troutman M.
PMID: 22612685
Bioanalysis. 2012 May;4(9):1039-56. doi: 10.4155/bio.12.87.

BACKGROUND: The number of new chemical entities and types of in vitro and in vivo samples that require bioanalysis in drug discovery is large and diverse. In addition, method development time is limited as data turnaround is the highest...

Study of drug function based on similarity of pathway fingerprint.

Protein & cell

Ye H, Tang K, Yang L, Cao Z, Li Y.
PMID: 22426982
Protein Cell. 2012 Feb;3(2):132-9. doi: 10.1007/s13238-012-2011-z. Epub 2012 Mar 17.

Drugs sharing similar therapeutic function may not bind to the same group of targets. However, their targets may be involved in similar pathway profiles which are associated with certain pathological process. In this study, pathway fingerprint was introduced to...

Study of drug function based on similarity of pathway fingerprint.

Protein & cell

Ye H, Tang K, Yang L, Cao Z, Li Y.
PMID: 22426982
Protein Cell. 2012 Feb;3(2):132-9. doi: 10.1007/s13238-012-2011-z. Epub 2012 Mar 17.

Drugs sharing similar therapeutic function may not bind to the same group of targets. However, their targets may be involved in similar pathway profiles which are associated with certain pathological process. In this study, pathway fingerprint was introduced to...

Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is it Worth It?.

CPT: pharmacometrics & systems pharmacology

Tod M, Goutelle S, Bourguignon L, Bleyzac N.
PMID: 27984676
CPT Pharmacometrics Syst Pharmacol. 2017 Apr;6(4):226. doi: 10.1002/psp4.12164. Epub 2017 Apr 11.

No abstract available.

In silico drug repositioning based on drug-miRNA associations.

Briefings in bioinformatics

Zhou X, Dai E, Song Q, Ma X, Meng Q, Jiang Y, Jiang W.
PMID: 30753359
Brief Bioinform. 2020 Mar 23;21(2):498-510. doi: 10.1093/bib/bbz012.

Drug repositioning has become a prevailing tactic as this strategy is efficient, economical and low risk for drug discovery. Meanwhile, recent studies have confirmed that small-molecule drugs can modulate the expression of disease-related miRNAs, which indicates that miRNAs are...

Authors' Reply to Uysal and Colleagues' Comment on: "Evaluation of Potential Drug-Drug Interactions in Adults in the Intensive Care Unit: A Systematic Review and Meta-Analysis".

Drug safety

Wong A, Fitzmaurice MG, Smithburger PL, Buckley MS, Kane-Gill SL.
PMID: 31997288
Drug Saf. 2020 Feb;43(2):195-196. doi: 10.1007/s40264-020-00910-x.

No abstract available.

Clinically significant drug interactions of antiretrovirals.

Casopis lekaru ceskych

Murínová I.
PMID: 31995995
Cas Lek Cesk. 2019;158(7):289-294.

Evaluating of the clinical significance of drug interactions is one of the domains of clinical pharmacist expertise. Drug interactions are discussed when two or more drugs co-administer and the effect of one of them changes. Drug interactions can be...

Correspondence to comments and controversy.

Clinics in dermatology

Stockley I.
PMID: 14678726
Clin Dermatol. 2003 Sep-Oct;21(5):459. doi: 10.1016/j.clindermatol.2003.08.002.

No abstract available.

Showing 1 to 12 of 14 entries