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The cryopreservation of liposomes. 1. A differential scanning calorimetry study of the thermal behavior of a liposome dispersion containing mannitol during freezing/thawing.

Pharmaceutical research

Talsma H, van Steenbergen MJ, Salemink PJ, Crommelin DJ.
PMID: 1924154
Pharm Res. 1991 Aug;8(8):1021-6. doi: 10.1023/a:1015857008057.

The thermal behavior of water in liposome dispersions and in liposome dispersions containing mannitol at subzero temperatures was investigated with differential scanning calorimetry (DSC). The cooling curves from 20 down to -60 degrees C for a liposome dispersion (bilayer...

A study of the stability of W/O/W multiple emulsions.

Journal of microencapsulation

Yan N, Zhang M, Ni P.
PMID: 1593397
J Microencapsul. 1992 Apr-Jun;9(2):143-51.

The stability of W/O/W emulsions has been studied in batch agitators. The surfactants suitable for W/O/W emulsions were screened and the factors affecting the emulsion stability were also studied. Results showed that polyamine E644 was an excellent emulsifier for...

The use of liposomes for the preparation of protein-free lipid emulsions models of chylomicron remnants.

Journal of microencapsulation

Vuaridel-Bonanomi ES, Weder HG.
PMID: 1765900
J Microencapsul. 1991 Apr-Jun;8(2):203-14. doi: 10.3109/02652049109071488.

Artificial chylomicron remnants were investigated as a new drug carrier system for the targeting of hepatic parenchymal cells. The emulsions presented here are similar in particle size and composition to natural lipoproteins. The preparations contained triolein, phospholipid, cholesterol and...

Use of a gel-forming dipeptide derivative as a carrier for antigen presentation.

Journal of peptide science : an official publication of the European Peptide Society

Vegners R, Shestakova I, Kalvinsh I, Ezzell RM, Janmey PA.
PMID: 9223016
J Pept Sci. 1995 Nov-Dec;1(6):371-8. doi: 10.1002/psc.310010604.

A dipeptide of the formula Fmoc-Leu-Asp and some other related dipeptides were synthesized in solution by standard methods. When such peptides are dissolved in water at concentrations below 1% at 100 degrees C and cooled below 60 degrees C...

A cyclodextrin dimer with a photocleavable linker as a possible carrier for the photosensitizer in photodynamic tumor therapy.

Proceedings of the National Academy of Sciences of the United States of America

Ruebner A, Yang Z, Leung D, Breslow R.
PMID: 10611274
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14692-3. doi: 10.1073/pnas.96.26.14692.

A cyclodextrin dimer has been synthesized with two beta-cyclodextrins linked by a flexible chain containing a carbon-carbon double bond. This dimer binds and solubilizes a phthalocyanine-based photosensitizer that generates singlet oxygen on irradiation. When the complex is irradiated, the...

Pronucleotides: toward the in vivo delivery of antiviral and anticancer nucleotides.

Medicinal research reviews

Wagner CR, Iyer VV, McIntee EJ.
PMID: 11058891
Med Res Rev. 2000 Nov;20(6):417-51. doi: 10.1002/1098-1128(200011)20:6<417::aid-med1>3.0.co;2-z.

To overcome the many hurdles preventing the use of antiviral and anticancer nucleosides as therapeutics, the development of a prodrug methodology (i.e., pronucleotide) for the in vivo delivery of nucleotides has been proposed as a solution. The ideal pronucleotide...

Development of a rectal nicotine delivery system for the treatment of ulcerative colitis.

International journal of pharmaceutics

Dash AK, Gong Z, Miller DW, Huai-Yan H, Laforet J.
PMID: 10528093
Int J Pharm. 1999 Nov 10;190(1):21-34. doi: 10.1016/s0378-5173(99)00221-5.

The aims of this investigation were: i. to develop a rectal nicotine delivery system with bioadhesives for the treatment of ulcerative colitis and ii. to evaluate nicotine transport and cytotoxicity of the delivery system using Caco-2 cell culture systems....

Stability determination of solid lipid nanoparticles (SLN) in aqueous dispersion after addition of electrolyte.

Journal of microencapsulation

Freitas C, Müller RH.
PMID: 9972503
J Microencapsul. 1999 Jan-Feb;16(1):59-71. doi: 10.1080/026520499289310.

The contribution of mono-, di- and trivalent ions to the destabilization of solid lipid nanoparticle (SLN) dispersions was investigated, i.e. particle growth and subsequent formation of semi-solid gels. Sodium, calcium and aluminium chloride were added in varying concentrations to...

Carbohydrate- and related polyol-derived fluorosurfactants: an update.

Carbohydrate research

Riess JG, Greiner J.
PMID: 10968680
Carbohydr Res. 2000 Jul 10;327(1):147-68. doi: 10.1016/s0008-6215(00)00012-4.

A short review of recent literature is presented on the synthesis, biological properties, colloid and surface chemistry, and applications of carbohydrate- and related polyol-derived amphiphiles with perfluoroalkyl hydrophobes.

Protein conjugates of defined structure: synthesis and use of a new carrier molecule.

Bioconjugate chemistry

Vilaseca LA, Rose K, Werlen R, Meunier A, Offord RE, Nichols CL, Scott WL.
PMID: 8305521
Bioconjug Chem. 1993 Nov-Dec;4(6):515-20. doi: 10.1021/bc00024a014.

A new carrier molecule, NH2OCH2CO-(Gly)3-[Lys(H-Ser-)]5-Gly-OH, has been synthesized to facilitate the preparation of protein conjugates of defined structure. Special features are as follows: (i) (aminooxy)-acetyl as a terminal group, which reacts specifically to form an oxime bond under very...

The physicochemical and biopharmaceutical properties of fragmented keratin as a new drug carrier.

Biological & pharmaceutical bulletin

Noda J, Imai T, Kida K, Otagiri M.
PMID: 8924920
Biol Pharm Bull. 1996 Mar;19(3):466-73. doi: 10.1248/bpb.19.466.

Two types of fragmented keratin were prepared from buffalo horn and hoof using savinase and Na2S, and their physicochemical and biopharmaceutical properties were examined in mice. The number-average molecular weight of enzymatically fragmented keratin (E-FK), chemically fragmented keratin (C-FK),...

Application of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) lipid conjugates as steric barrier molecules in liposomal formulations.

Bioconjugate chemistry

Ansell SM, Kojic LD, Hankins JS, Sekirov L, Boey A, Lee DK, Bennett AR, Klimuk SK, Harasym TO, Dos Santos N, Semple SC.
PMID: 10411464
Bioconjug Chem. 1999 Jul-Aug;10(4):653-66. doi: 10.1021/bc990005p.

Lipid conjugates of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) (ATTAn) were synthesized as monodisperse analogues of poly(ethylene glycol) (PEG) derivatives used in liposomal drug delivery systems. The new lipids were shown to be at least equivalent to MePEGA-2000-DSPE in assays designed to evaluate...

Showing 1 to 12 of 26299 entries