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Regional distribution of alpha 1-adrenoceptor subtypes in rat kidney.

The Journal of pharmacology and experimental therapeutics

Feng F, Pettinger WA, Abel PW, Jeffries WB.
PMID: 1677042
J Pharmacol Exp Ther. 1991 Jul 01;258(1):263-8.

alpha 1-Adrenoceptors are expressed in high density in the rat kidney. Recent studies have shown that alpha 1-adrenoceptors are heterogeneous and can be subtyped based on their affinity for the antagonists WB 4101 (alpha 1A greater than alpha 1B)...

Glutaraldehyde pretreatment blocks phospholipase A2 modulation of adrenergic receptors.

Life sciences

Cohen RM, McLellan C, Dauphin M, Hirata F.
PMID: 2857044
Life Sci. 1985 Jan 07;36(1):25-32. doi: 10.1016/0024-3205(85)90282-6.

Treatment of rat cerebral cortical membranes with phospholipase A2 affects, in a parallel fashion, beta-, alpha 1- and alpha 2-adrenergic receptor binding, but not the affinity of these receptors for their respective ligands. Pretreatment of membranes with 0.1 percent...

Interaction of the pesticide chlordimeform with adrenergic receptors in mouse brain: an in vitro study.

Archives of toxicology

Costa LG, Murphy SD.
PMID: 3034195
Arch Toxicol. 1987 Feb;59(5):323-7. doi: 10.1007/BF00295083.

Chlordimeform (N'(4-chloro-o-tolyl)-N, N-dimethylformamidine; CDM) is a formamidine insecticide acaricide whose major active metabolite is its N-monomethyl analog, desmethylchlordimeform, (DCDM). While their pesticidal action in invertebrates appears to be related to activation of octopamine receptors, their mechanism of action in...

Transient elevation of amygdala alpha 2 adrenergic receptor binding sites during the early stages of amygdala kindling.

Epilepsy research

Chen MJ, Vigil A, Savage DD, Weiss GK.
PMID: 2158441
Epilepsy Res. 1990 Mar;5(2):85-91. doi: 10.1016/0920-1211(90)90023-o.

Enhanced noradrenergic neurotransmission retards but does not prevent the development of kindling. We previously reported that locus coeruleus (LC) alpha 2 adrenergic receptor binding sites are transiently elevated during the early stages of kindling development. Since the firing activity...

Different alpha 2-adrenoceptor densities in the circular and longitudinal layers of human near-term myometrium as revealed by [3H]-idazoxan binding studies.

Gynecologic and obstetric investigation

Breuiller M, Rouot B, Leroy MJ, Blot P, Ferré F.
PMID: 2901998
Gynecol Obstet Invest. 1988;26(1):14-20. doi: 10.1159/000293666.

[3H]-idazoxan, a specific alpha 2-adrenoceptor antagonist radioligand, has been used to characterize alpha 2-adrenoceptors in both circular and longitudinal layers of human near-term myometrium. [3H]-idazoxan binding is reversible, saturable and stereospecific. It labels with high affinity a single population...

Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: role of disulfide and sulfhydryl groups.

Neurochemical research

Reader TA, Brière R, Grondin L.
PMID: 2870441
Neurochem Res. 1986 Jan;11(1):9-27. doi: 10.1007/BF00965161.

The tritiated adrenergic antagonists Prazosin ([3H]PRZ) and Idazoxan ([3H]IDA, or RX-781094) bind specifically and with high affinity to alpha 1 and alpha 2-adrenoceptors respectively, in membrane preparations from cerebral cortex. Saturation experiments performed to determine the density of receptors...

Excretion of toxaphene and dioxathion in the milk of dairy.

Bulletin of animal health and production in Africa. Bulletin des sante et production animales en Afrique

Keating MI.
PMID: 548142
Bull Anim Health Prod Afr. 1979 Dec;27(4):279-86.

No abstract available.

Quantification of in vivo binding of [3H]RX 821002 in rat brain: evaluation as a radioligand for central alpha 2-adrenoceptors.

International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

Hume SP, Lammertsma AA, Opacka-Juffry J, Ahier RG, Myers R, Cremer JE, Hudson AL, Nutt DJ, Pike VW.
PMID: 1358860
Int J Rad Appl Instrum B. 1992 Nov;19(8):841-9. doi: 10.1016/0883-2897(92)90170-4.

On the basis of its established in vitro characteristics, [3H]RX 821002 was evaluated in rats as an in vivo radioligand for central alpha 2-adrenoceptors. Estimates for in vivo binding potential, obtained by compartmental analyses of time-radioactivity data, ranged between...

The pharmacokinetics and metabolism of idazoxan in the rat.

Xenobiotica; the fate of foreign compounds in biological systems

Lewis CJ, Havler ME, Humphrey MJ, Lloyd-Jones JG, McCleavy MA, Muir NC, Waltham K.
PMID: 2899932
Xenobiotica. 1988 May;18(5):519-32. doi: 10.3109/00498258809041689.

1. [2'-14C]Idazoxan was rapidly and completely absorbed after its oral administration to rats. 2. After administration of either [2'-14C] or [6,7-3H]idazoxan, radioactivity was taken up by a wide range of tissues and became localized, especially in the organs of...

Heterogeneity between soluble human and rabbit splenic alpha 2-adrenoceptors.

Biochemical pharmacology

McKernan RM, Dickinson KE, Miles CM, Sever PS.
PMID: 2876709
Biochem Pharmacol. 1986 Oct 15;35(20):3517-23. doi: 10.1016/0006-2952(86)90621-0.

The pharmacological and biochemical characteristics of soluble alpha 2-adrenoceptors were investigated to determine whether differences observed in membranes were maintained in solution and to probe the nature of any such differences. alpha 2-Adrenoceptors were solubilized from purified plasma membrane...

Repeated idazoxan increases brain imidazoline receptors in normotensive (WKY) but not in hypertensive (SHR) rats.

Journal of neurochemistry

Olmos G, Miralles A, Barturen F, García-Sevilla JA.
PMID: 1681037
J Neurochem. 1991 Nov;57(5):1811-3. doi: 10.1111/j.1471-4159.1991.tb06386.x.

The specific binding of [3H]idazoxan in the presence of 10(-6) M (-)-adrenaline was used to evaluate the density of imidazoline receptors in the brain of spontaneously hypertensive (SHR) rats and sex- and age-matched normotensive Wistar-Kyoto (WKY) rats. In SHR...

Imidazoline-guanidinium receptive site in renal proximal tubule: asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance.

The Journal of pharmacology and experimental therapeutics

Coupry I, Atlas D, Podevin RA, Uzielli I, Parini A.
PMID: 2153803
J Pharmacol Exp Ther. 1990 Jan;252(1):293-9.

In the present report we have used [3H]idazoxan to characterize the rabbit renal imidazoline preferring site by defining its plasmalemma distribution, its regulation by cations and the type of interaction with the clonidine displacing substance (CDS), a putative endogenous...

Showing 1 to 12 of 486 entries