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Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men.

The Journal of clinical endocrinology and metabolism

Nestler JE, Barlascini CO, Clore JN, Blackard WG.
PMID: 2961787
J Clin Endocrinol Metab. 1988 Jan;66(1):57-61. doi: 10.1210/jcem-66-1-57.

To assess the effects of dehydroepiandrosterone (DHEA) on body fat mass, serum lipid levels, and tissue sensitivity to insulin, five normal men were given placebo and five normal men were given oral DHEA [1600 mg/day (554.7 mmol/day)] for 28...

Sex hormones and bone metabolism in postmenopausal rheumatoid arthritis treated with two different glucocorticoids.

The Journal of rheumatology

Montecucco C, Caporali R, Caprotti P, Caprotti M, Notario A.
PMID: 1294736
J Rheumatol. 1992 Dec;19(12):1895-900.

To investigate the effect of low doses of 2 different glucocorticoids on bone mass, sex hormone status and bone metabolic indices, a study was undertaken in 16 postmenopausal women with rheumatoid arthritis (RA) receiving < 15 mg/day of deflazacort...

Endocrine effects of aminoglutethimide plus hydrocortisone versus effects of high dose of hydrocortisone alone in postmenopausal metastatic breast cancer.

European journal of cancer & clinical oncology

Alexieva-Figusch J, de Jong FH, Lamberts WJ, van Gilse HA, Klign JG.
PMID: 2960533
Eur J Cancer Clin Oncol. 1987 Sep;23(9):1349-56. doi: 10.1016/0277-5379(87)90119-2.

Aminoglutethimide (Ag) has been used in different dosages with and without combined treatment with glucocorticoids for the suppression of peripheral plasma levels of steroidal hormones. In the present work we have estimated changes in peripheral steroid levels after 3...

Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders.

Physiology & behavior

Schlegel ML, Spetz JF, Robel P, Haug M.
PMID: 2932747
Physiol Behav. 1985 Jun;34(6):867-70. doi: 10.1016/0031-9384(85)90005-8.

Triads of castrated male mice (residents) were injected each day for 2 weeks with oil vehicle or 280 nmol of dehydroepiandrosterone (D). They were tested for their attack on a lactating female (intruder) introduced in their home-cage 2,24 or...

Simultaneous determination of five androgens in early neonatal urine by selected ion monitoring GC-MS using 19-d3 steroids as internal standards.

Endocrinologia japonica

Yamaguchi T, Konno K, Kawabe K, Yasuda K, Mori H, Suzuki T, Yanaihara T, Nakayama T.
PMID: 2931276
Endocrinol Jpn. 1985 Apr;32(2):279-85. doi: 10.1507/endocrj1954.32.279.

Androgen levels in early neonatal urine were measured by GC-MS using trideuterated steroids at C-19 as internal standards. The deuterated steroid is not only stable in the process of analysis but also behaves chemically the same as the corresponding...

The biological fate of sodium prasterone sulfate after vaginal administration. I. Absorption and excretion in rats.

Journal of pharmacobio-dynamics

Sakaguchi M, Sakai T, Adachi Y, Kawashima T, Awata N.
PMID: 1403604
J Pharmacobiodyn. 1992 Feb;15(2):67-73. doi: 10.1248/bpb1978.15.67.

The absorption and excretion of sodium prasterone sulfate (PS) (sodium dehydroepiandrosterone sulfate) were studied in rats after vaginal administration of 14C-PS. In late pregnant rats, maximum plasma level (Cmax) appeared at 2-4 h after dosing and both Cmax and...

Effects of cyclic adenosine monophosphate on human chorionic gonadotropin and estradiol output by cultured human placental cells.

American journal of obstetrics and gynecology

Benoit J, Rodway M, Yuen BH, Leung PC.
PMID: 2963543
Am J Obstet Gynecol. 1988 Feb;158(2):328-32. doi: 10.1016/0002-9378(88)90148-2.

We have previously shown that adenosine-3',5'-cyclic monophosphate (cAMP) inhibits basal estradiol output in human trophoblast cells. The objective of this study was to investigate further the effect of 8-bromo-cAMP on the conversion of C19 androgens to estradiol by placental...

Quantification of steroid conjugates using fast atom bombardment mass spectrometry.


Gaskell SJ.
PMID: 2149220
Steroids. 1990 Oct;55(10):458-62. doi: 10.1016/0039-128x(90)90014-3.

Fast atom bombardment/mass spectrometry or liquid secondary ion mass spectrometry provides the capability for direct analysis of steroid conjugates (sulfates, glucuronides) without prior hydrolysis or derivatization. During the analysis of biologic extracts, limitations on the sensitivity of detection arise...

Dehydroepiandrosterone sulfate quantification in serum using high-performance liquid chromatography/mass spectrometry and a deuterated internal standard: a technique suitable for routine use or as a reference method.


Shackleton CH, Kletke C, Wudy S, Pratt JH.
PMID: 2149221
Steroids. 1990 Oct;55(10):472-8. doi: 10.1016/0039-128x(90)90016-5.

A thermospray high-performance liquid chromatography/mass spectrometry method for determination of serum dehydroepiandrosterone sulfate is described. The steroid was measured intact using [7,7-2H2]dehydroepiandrosterone sulfate as internal standard. The analysis was carried out in the negative ion mode by determining the...

The concentration of 16x-hydroxy androgens in serum and cyst fluid of women with gross cystic disease of the breast.


Raju U, Bradlow HL, Skidmore FD, Levitz M.
PMID: 2530661
Steroids. 1989 Jul;54(1):101-12. doi: 10.1016/0039-128x(89)90077-9.

The concentrations of 16 alpha-hydroxydehydroepi-androsterone sulfate (16 alpha-OHDHAS) and androst-5-ene-3 beta, 16 alpha-, 17 beta-triol-3-sulfate (A-TriolS) were measured in the plasma and breast cyst fluid (BCF) of women with gross cystic disease of the breast. In the 19 BCF...

Sex steroids and bone density in premenopausal and perimenopausal women.

The Journal of clinical endocrinology and metabolism

Steinberg KK, Freni-Titulaer LW, DePuey EG, Miller DT, Sgoutas DS, Coralli CH, Phillips DL, Rogers TN, Clark RV.
PMID: 2527242
J Clin Endocrinol Metab. 1989 Sep;69(3):533-9. doi: 10.1210/jcem-69-3-533.

Bone density begins to decline in women before menopause, and the degree of bone loss is variable. We performed a cross-sectional analysis on the entry data of a 5-yr prospective study of risk factors for osteoporosis to determine the...

Basal serum dehydroepiandrosterone sulphate concentration does not predict the cortisol response to provocative testing.

Annals of clinical biochemistry

Littley MD, Pollock A, Kane J, Shalet SM.
PMID: 2150469
Ann Clin Biochem. 1990 Nov;27:557-61. doi: 10.1177/000456329002700606.

The concentration of dehydroepiandrosterone sulphate (DHEAS) was measured in the plasma of 104 patients aged 16-78 years (48 men) undergoing routine assessment of anterior pituitary reserve. A fasting plasma sample was collected at 0900 h on the same day...

Showing 1 to 12 of 1523 entries