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Nanotoxicology: damaging DNA from a distance.

Nature nanotechnology

Myllynen P.
PMID: 19966824
Nat Nanotechnol. 2009 Dec;4(12):795-6. doi: 10.1038/nnano.2009.365.

No abstract available.

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Myllynen P. Nanotoxicology: damaging DNA from a distance. Nat Nanotechnol. 2009;4(12):795-6doi: 10.1038/nnano.2009.365.
Myllynen, P. (2009). Nanotoxicology: damaging DNA from a distance. Nature nanotechnology, 4(12), 795-6. https://doi.org/10.1038/nnano.2009.365
Myllynen, Päivi. "Nanotoxicology: damaging DNA from a distance." Nature nanotechnology vol. 4,12 (2009): 795-6. doi: https://doi.org/10.1038/nnano.2009.365
Myllynen P. Nanotoxicology: damaging DNA from a distance. Nat Nanotechnol. 2009 Dec;4(12):795-6. doi: 10.1038/nnano.2009.365. PMID: 19966824.
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Genotoxicity testing in vitro - development of a higher throughput analysis method based on the comet assay.

Toxicology in vitro : an international journal published in association with BIBRA

Ritter D, Knebel J.
PMID: 19595757
Toxicol In Vitro. 2009 Dec;23(8):1570-5. doi: 10.1016/j.tiv.2009.07.007. Epub 2009 Jul 10.

Higher throughput methods, high content analysis and automated screening methods are of highest demand in drug development today. In toxicology, these strategies are becoming increasingly important, as well. Therefore, an integrated higher throughput method for the comet assay is...

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Ritter D, Knebel J. Genotoxicity testing in vitro - development of a higher throughput analysis method based on the comet assay. Toxicol In Vitro. 2009;23(8):1570-5doi: 10.1016/j.tiv.2009.07.007.
Ritter, D., & Knebel, J. (2009). Genotoxicity testing in vitro - development of a higher throughput analysis method based on the comet assay. Toxicology in vitro : an international journal published in association with BIBRA, 23(8), 1570-5. https://doi.org/10.1016/j.tiv.2009.07.007
Ritter, Detlef, and Knebel, Jan. "Genotoxicity testing in vitro - development of a higher throughput analysis method based on the comet assay." Toxicology in vitro : an international journal published in association with BIBRA vol. 23,8 (2009): 1570-5. doi: https://doi.org/10.1016/j.tiv.2009.07.007
Ritter D, Knebel J. Genotoxicity testing in vitro - development of a higher throughput analysis method based on the comet assay. Toxicol In Vitro. 2009 Dec;23(8):1570-5. doi: 10.1016/j.tiv.2009.07.007. Epub 2009 Jul 10. PMID: 19595757.
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MicroRNA changes in advanced radiotherapy techniques and its effect to secondary cancers.

Medical hypotheses

Sert F.
PMID: 22658362
Med Hypotheses. 2012 Sep;79(3):421-2. doi: 10.1016/j.mehy.2012.05.026. Epub 2012 Jun 01.

MicroRNAs (miRNAs) are a kind of RNA, produced copies of endogenous hairpin-shaped, are 21-25 nucleotide length, small, and single chain. Recent studies have revealed that hundreds of miRNAs are found in the human genome and are responsible for diverse...

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Sert F. MicroRNA changes in advanced radiotherapy techniques and its effect to secondary cancers. Med Hypotheses. 2012;79(3):421-2doi: 10.1016/j.mehy.2012.05.026.
Sert, F. (2012). MicroRNA changes in advanced radiotherapy techniques and its effect to secondary cancers. Medical hypotheses, 79(3), 421-2. https://doi.org/10.1016/j.mehy.2012.05.026
Sert, Fatma. "MicroRNA changes in advanced radiotherapy techniques and its effect to secondary cancers." Medical hypotheses vol. 79,3 (2012): 421-2. doi: https://doi.org/10.1016/j.mehy.2012.05.026
Sert F. MicroRNA changes in advanced radiotherapy techniques and its effect to secondary cancers. Med Hypotheses. 2012 Sep;79(3):421-2. doi: 10.1016/j.mehy.2012.05.026. Epub 2012 Jun 01. PMID: 22658362.
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The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response.

Cancer communications (London, England)

Devecchi A, De Cecco L, Dugo M, Penso D, Dagrada G, Brich S, Stacchiotti S, Sensi M, Canevari S, Pilotti S.
PMID: 30486883
Cancer Commun (Lond). 2018 Nov 28;38(1):70. doi: 10.1186/s40880-018-0339-3.

BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive, and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1 (EWSR1)-Wilm's tumor suppressor (WT1) translocation. We used...

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Devecchi A, De Cecco L, Dugo M, et al. The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response. Cancer Commun (Lond). 2018;38(1):70doi: 10.1186/s40880-018-0339-3.
Devecchi, A., De Cecco, L., Dugo, M., Penso, D., Dagrada, G., Brich, S., Stacchiotti, S., Sensi, M., Canevari, S., & Pilotti, S. (2018). The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response. Cancer communications (London, England), 38(1), 70. https://doi.org/10.1186/s40880-018-0339-3
Devecchi, Andrea, et al. "The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response." Cancer communications (London, England) vol. 38,1 (2018): 70. doi: https://doi.org/10.1186/s40880-018-0339-3
Devecchi A, De Cecco L, Dugo M, Penso D, Dagrada G, Brich S, Stacchiotti S, Sensi M, Canevari S, Pilotti S. The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response. Cancer Commun (Lond). 2018 Nov 28;38(1):70. doi: 10.1186/s40880-018-0339-3. PMID: 30486883; PMCID: PMC6260689.
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DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis.

Sports medicine (Auckland, N.Z.)

Tryfidou DV, McClean C, Nikolaidis MG, Davison GW.
PMID: 31529301
Sports Med. 2020 Jan;50(1):103-127. doi: 10.1007/s40279-019-01181-y.

BACKGROUND: Exercise is widely recognised for its health enhancing benefits. Despite this, an overproduction of reactive oxygen and nitrogen species (RONS), outstripping antioxidant defence mechanisms, can lead to a state of (chronic) oxidative stress. DNA is a vulnerable target...

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Tryfidou DV, McClean C, Nikolaidis MG, et al. DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis. Sports Med. 2020;50(1):103-127doi: 10.1007/s40279-019-01181-y.
Tryfidou, D. V., McClean, C., Nikolaidis, M. G., & Davison, G. W. (2020). DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis. Sports medicine (Auckland, N.Z.), 50(1), 103-127. https://doi.org/10.1007/s40279-019-01181-y
Tryfidou, Despoina V, et al. "DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis." Sports medicine (Auckland, N.Z.) vol. 50,1 (2020): 103-127. doi: https://doi.org/10.1007/s40279-019-01181-y
Tryfidou DV, McClean C, Nikolaidis MG, Davison GW. DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis. Sports Med. 2020 Jan;50(1):103-127. doi: 10.1007/s40279-019-01181-y. PMID: 31529301; PMCID: PMC6942015.
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Simple and complex double-strand breaks induced by electrons.

International journal of radiation biology

Michalik V, Frankenberg D.
PMID: 7983433
Int J Radiat Biol. 1994 Nov;66(5):467-70. doi: 10.1080/09553009414551471.

Biophysical modelling of DNA damage based on Monte Carlo simulation of charged particle tracks allows to describe radiation induced double-strand breaks (dsb) in a quantitative and qualitative way. Experimental and calculated data suggest that in the electron energy range...

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Michalik V, Frankenberg D. Simple and complex double-strand breaks induced by electrons. Int J Radiat Biol. 1994;66(5):467-70doi: 10.1080/09553009414551471.
Michalik, V., & Frankenberg, D. (1994). Simple and complex double-strand breaks induced by electrons. International journal of radiation biology, 66(5), 467-70. https://doi.org/10.1080/09553009414551471
Michalik, V, and Frankenberg, D. "Simple and complex double-strand breaks induced by electrons." International journal of radiation biology vol. 66,5 (1994): 467-70. doi: https://doi.org/10.1080/09553009414551471
Michalik V, Frankenberg D. Simple and complex double-strand breaks induced by electrons. Int J Radiat Biol. 1994 Nov;66(5):467-70. doi: 10.1080/09553009414551471. PMID: 7983433.
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CRISPR and Chromothripsis: Proceed with Caution.

The CRISPR journal

Mack S, Russell IA.
PMID: 34152218
CRISPR J. 2021 Jun;4(3):309-312. doi: 10.1089/crispr.2021.29128.sma.

No abstract available.

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Mack S, Russell IA. CRISPR and Chromothripsis: Proceed with Caution. CRISPR J. 2021;4(3):309-312doi: 10.1089/crispr.2021.29128.sma.
Mack, S., & Russell, I. A. (2021). CRISPR and Chromothripsis: Proceed with Caution. The CRISPR journal, 4(3), 309-312. https://doi.org/10.1089/crispr.2021.29128.sma
Mack, Stephanie, and Russell, I Alasdair. "CRISPR and Chromothripsis: Proceed with Caution." The CRISPR journal vol. 4,3 (2021): 309-312. doi: https://doi.org/10.1089/crispr.2021.29128.sma
Mack S, Russell IA. CRISPR and Chromothripsis: Proceed with Caution. CRISPR J. 2021 Jun;4(3):309-312. doi: 10.1089/crispr.2021.29128.sma. PMID: 34152218.
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The Croonian Lecture, 1996: endogenous damage to DNA.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Lindahl T.
PMID: 8962440
Philos Trans R Soc Lond B Biol Sci. 1996 Nov 29;351(1347):1529-38. doi: 10.1098/rstb.1996.0139.

Although DNA is the carrier of stable genetic information, this giant molecule exhibits slow turnover in cells as a consequence of endogenous damage. DNA lesions result from hydrolysis, and from exposure to active oxygen and reactive metabolites. These major...

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Lindahl T. The Croonian Lecture, 1996: endogenous damage to DNA. Philos Trans R Soc Lond B Biol Sci. 1996;351(1347):1529-38doi: 10.1098/rstb.1996.0139.
Lindahl, T. (1996). The Croonian Lecture, 1996: endogenous damage to DNA. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 351(1347), 1529-38. https://doi.org/10.1098/rstb.1996.0139
Lindahl, T. "The Croonian Lecture, 1996: endogenous damage to DNA." Philosophical transactions of the Royal Society of London. Series B, Biological sciences vol. 351,1347 (1996): 1529-38. doi: https://doi.org/10.1098/rstb.1996.0139
Lindahl T. The Croonian Lecture, 1996: endogenous damage to DNA. Philos Trans R Soc Lond B Biol Sci. 1996 Nov 29;351(1347):1529-38. doi: 10.1098/rstb.1996.0139. PMID: 8962440.
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CometChip: a high-throughput 96-well platform for measuring DNA damage in microarrayed human cells.

Journal of visualized experiments : JoVE

Ge J, Prasongtanakij S, Wood DK, Weingeist DM, Fessler J, Navasummrit P, Ruchirawat M, Engelward BP.
PMID: 25350601
J Vis Exp. 2014 Oct 18;(92):e50607. doi: 10.3791/50607.

DNA damaging agents can promote aging, disease and cancer and they are ubiquitous in the environment and produced within human cells as normal cellular metabolites. Ironically, at high doses DNA damaging agents are also used to treat cancer. The...

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Ge J, Prasongtanakij S, Wood DK, et al. CometChip: a high-throughput 96-well platform for measuring DNA damage in microarrayed human cells. J Vis Exp. 2014;(92):e50607doi: 10.3791/50607.
Ge, J., Prasongtanakij, S., Wood, D. K., Weingeist, D. M., Fessler, J., Navasummrit, P., Ruchirawat, M., & Engelward, B. P. (2014). CometChip: a high-throughput 96-well platform for measuring DNA damage in microarrayed human cells. Journal of visualized experiments : JoVE, (92), e50607. https://doi.org/10.3791/50607
Ge, Jing, et al. "CometChip: a high-throughput 96-well platform for measuring DNA damage in microarrayed human cells." Journal of visualized experiments : JoVE vol. ,92 (2014): e50607. doi: https://doi.org/10.3791/50607
Ge J, Prasongtanakij S, Wood DK, Weingeist DM, Fessler J, Navasummrit P, Ruchirawat M, Engelward BP. CometChip: a high-throughput 96-well platform for measuring DNA damage in microarrayed human cells. J Vis Exp. 2014 Oct 18;(92):e50607. doi: 10.3791/50607. PMID: 25350601; PMCID: PMC4407627.
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On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response.

Cells

Pavan ICB, Peres de Oliveira A, Dias PRF, Basei FL, Issayama LK, Ferezin CC, Silva FR, Rodrigues de Oliveira AL, Alves Dos Reis Moura L, Martins MB, Simabuco FM, Kobarg J.
PMID: 33673578
Cells. 2021 Feb 27;10(3). doi: 10.3390/cells10030507.

NIMA-related kinases, or NEKs, are a family of Ser/Thr protein kinases involved in cell cycle and mitosis, centrosome disjunction, primary cilia functions, and DNA damage responses among other biological functional contexts in vertebrate cells. In human cells, there are...

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Pavan ICB, Peres de Oliveira A, Dias PRF, et al. On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response. Cells. 2021;10(3)doi: 10.3390/cells10030507.
Pavan, I. C. B., Peres de Oliveira, A., Dias, P. R. F., Basei, F. L., Issayama, L. K., Ferezin, C. C., Silva, F. R., Rodrigues de Oliveira, A. L., Alves Dos Reis Moura, L., Martins, M. B., Simabuco, F. M., & Kobarg, J. (2021). On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response. Cells, 10(3), . https://doi.org/10.3390/cells10030507
Pavan, Isadora Carolina Betim, et al. "On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response." Cells vol. 10,3 (2021). doi: https://doi.org/10.3390/cells10030507
Pavan ICB, Peres de Oliveira A, Dias PRF, Basei FL, Issayama LK, Ferezin CC, Silva FR, Rodrigues de Oliveira AL, Alves Dos Reis Moura L, Martins MB, Simabuco FM, Kobarg J. On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response. Cells. 2021 Feb 27;10(3). doi: 10.3390/cells10030507. PMID: 33673578; PMCID: PMC7997185.
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Critical factors to be considered when testing nanomaterials for genotoxicity with the comet assay.

Mutagenesis

Huk A, Collins AR, El Yamani N, Porredon C, Azqueta A, de Lapuente J, Dusinska M.
PMID: 25527731
Mutagenesis. 2015 Jan;30(1):85-8. doi: 10.1093/mutage/geu077.

The comet assay is widely used to test the genotoxicity of engineered nanomaterials (ENMs) but outcomes may vary when results from different laboratories, or even within one laboratory, are compared. We address some basic methodological considerations, such as the...

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Huk A, Collins AR, El Yamani N, et al. Critical factors to be considered when testing nanomaterials for genotoxicity with the comet assay. Mutagenesis. 2015;30(1):85-8doi: 10.1093/mutage/geu077.
Huk, A., Collins, A. R., El Yamani, N., Porredon, C., Azqueta, A., de Lapuente, J., & Dusinska, M. (2015). Critical factors to be considered when testing nanomaterials for genotoxicity with the comet assay. Mutagenesis, 30(1), 85-8. https://doi.org/10.1093/mutage/geu077
Huk, Anna, et al. "Critical factors to be considered when testing nanomaterials for genotoxicity with the comet assay." Mutagenesis vol. 30,1 (2015): 85-8. doi: https://doi.org/10.1093/mutage/geu077
Huk A, Collins AR, El Yamani N, Porredon C, Azqueta A, de Lapuente J, Dusinska M. Critical factors to be considered when testing nanomaterials for genotoxicity with the comet assay. Mutagenesis. 2015 Jan;30(1):85-8. doi: 10.1093/mutage/geu077. PMID: 25527731.
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DNA damage-induced immune response: Micronuclei provide key platform.

The Journal of cell biology

Gekara NO.
PMID: 28860276
J Cell Biol. 2017 Oct 02;216(10):2999-3001. doi: 10.1083/jcb.201708069. Epub 2017 Aug 31.

DNA damage-induced activation of the cytoplasmic DNA sensor cGAS influences the outcome of infections, autoinflammation, and cancer. Recent studies by Harding et al. (2017.

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Gekara NO. DNA damage-induced immune response: Micronuclei provide key platform. J Cell Biol. 2017;216(10):2999-3001doi: 10.1083/jcb.201708069.
Gekara, N. O. (2017). DNA damage-induced immune response: Micronuclei provide key platform. The Journal of cell biology, 216(10), 2999-3001. https://doi.org/10.1083/jcb.201708069
Gekara, Nelson O. "DNA damage-induced immune response: Micronuclei provide key platform." The Journal of cell biology vol. 216,10 (2017): 2999-3001. doi: https://doi.org/10.1083/jcb.201708069
Gekara NO. DNA damage-induced immune response: Micronuclei provide key platform. J Cell Biol. 2017 Oct 02;216(10):2999-3001. doi: 10.1083/jcb.201708069. Epub 2017 Aug 31. PMID: 28860276; PMCID: PMC5626557.
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Showing 1 to 12 of 18 entries