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A comparative study on the ototoxicity of dibekacin and tobramycin administered by intravenous infusion.

The Japanese journal of antibiotics

Ohtani I, Ohtsuki K, Aikawa T, Ouchi J, Nakayoshi T.
PMID: 513289
Jpn J Antibiot. 1979 Oct;32(10):990-7.

No abstract available.

10 years of experience with intratympanally applied streptomycin (gentamycin) in the therapy of Morbus Menière.

Archives of oto-rhino-laryngology

Beck C, Schmidt CL.
PMID: 751619
Arch Otorhinolaryngol. 1978 Sep 28;221(2):149-52. doi: 10.1007/BF00455886.

During the last 10 years a total of 83 patients with severe cases of unilateral Morbus Menière were treated in our clinic. The proposed therapy was to administer streptomycin (gentamycinsulfate) intratympanically by applying two different ways of procedure. In...

Cochlear toxicity of butikacin (UK-18,892), a new semisynthetic aminoglycoside antibiotic, in guinea pigs.

Antimicrobial agents and chemotherapy

Carter AJ.
PMID: 507791
Antimicrob Agents Chemother. 1979 Sep;16(3):362-5. doi: 10.1128/AAC.16.3.362.
Free PMC Article

The cochleotoxic potential of butikacin (UK-18,892), a new semisynthetic aminoglycoside, has been evaluated in neonatal guinea pigs in comparison with amikacin, gentamicin, and kanamycin A. All compounds produced a dose-related increase of the mean threshold sound intensity required to...

Evidence that catecholamines are not the afferent transmitter in the cochlea.

Experimental brain research

Klinke R, Evans EF.
PMID: 195827
Exp Brain Res. 1977 Jun 27;28(3):315-24. doi: 10.1007/BF00235713.

Beta-receptor blocking agents (practolol, propranolol) and alpha-receptor blocking agents (phenoxybenzamine, phentolamine), when applied intracochlearly do not eliminate the afferetn discharges or compound action potential of the cochlear nerve. Under the assumption that the drugs used reach the synaptic site,...

Quantitative analysis of kanamycin ototoxicosis.

Acta oto-laryngologica

Toyoda Y, Saito H, Matsuoka H, Takenaka H, Oshima W, Mizukoshi O.
PMID: 303038
Acta Otolaryngol. 1977 Sep-Oct;84(3):202-12. doi: 10.3109/00016487709123958.

The morphological changes after kanamycin intoxication of the inner ear, including both the cochlea and the vestibule, were quantitatively analysed by the surface preparation technique after succinic dehydrogenase staining. 75 guinea pigs were used. The outer hair cells in...

Damage to the stria vascularis in the guinea pig by acute atoxyl intoxication.

Acta oto-laryngologica

Anniko M, Wersäll J.
PMID: 170783
Acta Otolaryngol. 1975 Sep-Oct;80(3):167-79. doi: 10.3109/00016487509121316.

The aim of the present study was to show the morphological degeneration at the ultrastructural level, after damaging the stria vascularis experimentally. The acute lesions, after acute atoxyl intoxication, occur after about 12 hours, and begin as a degeneration...

Effect of neomycin on phosphoinositide labelling and calcium binding in guinea-pig inner ear tissues in vivo and in vitro.

Journal of neurochemistry

Orsulakova A, Stockhorst E, Schacht J.
PMID: 176322
J Neurochem. 1976 Feb;26(2):285-90. doi: 10.1111/j.1471-4159.1976.tb04478.x.

No abstract available.

[Cochleo-vestibular findings in carbon tetrachloride exposure].

Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete

Wenkebach P, Skurczynski W.
PMID: 301329
Z Gesamte Hyg. 1977 Mar;23(3):145-7.

No abstract available.

Early effects of ethacrynic acid on cochlear histochemistry.

Archives of otolaryngology (Chicago, Ill. : 1960)

Horn KL, Langley LR, Gates GA.
PMID: 145851
Arch Otolaryngol. 1978 Jan;104(1):42-6. doi: 10.1001/archotol.1978.00790010046010.

We have investigated the histochemical changes in the succinodehydrogenase (SDH) and adenosine triphosphatase (ATPase) enzyme systems of the guinea pig cochlea at 30, 60, and 240 minutes following the intracardiac injection of ethacrynic acid. In control animals, there is...

The effects of indomethacin on inner ear fluids and morphology.

The Journal of otolaryngology

Morrison MD, Blakley BW.
PMID: 650723
J Otolaryngol. 1978 Apr;7(2):149-57.

Metabolic disturbances may affect inner ear fluid homeostasis in various ways. The membrane sodium-potassium pump must play a role in this homeostasis, and as this pump derives energy from A.T.P. it may also depend somewhat on the presence of...

GABAA receptor antagonist bicuculline alters response properties of posteroventral cochlear nucleus neurons.

Journal of neurophysiology

Palombi PS, Caspary DM.
PMID: 1315848
J Neurophysiol. 1992 Mar;67(3):738-46. doi: 10.1152/jn.1992.67.3.738.

1. The role of GABAergic inhibitory inputs onto posteroventral cochlear nucleus (PVCN) neurons in the anesthetized chinchilla was investigated through iontophoretic application of the GABAA receptor agonist muscimol and the GABAA receptor antagonist bicuculline. The majority of the neurons...

Single-cell layer membrane covering the degenerated cochlear duct after perilymphatic perfusion of streptomycin.

Acta oto-laryngologica

Kaneko Y, Terayama Y, Kawamoto K, Kasajima K, Ise I.
PMID: 716860
Acta Otolaryngol. 1978 Nov-Dec;86(5):375-84. doi: 10.3109/00016487809107516.

Ultrastructural changes of the extrasensory epithelium in the scala media of guinea pig cochleae were observed from 3 to 137 days after perilymphatic perfusion with 20% streptomycin. The degeneration started in the organ of Corti, progressed to the interdental...

Showing 1 to 12 of 2346 entries