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Showing 1 to 12 of 2348 entries
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American Federation for Clinical Research and the Health Manpower Bill.

Clinical research

Challoner DR.
PMID: 800754
Clin Res. 1976 Apr;24(3):128-9.

No abstract available.

Fumes from the spleen.

Paediatric and perinatal epidemiology

[No authors listed]
PMID: 2587404
Paediatr Perinat Epidemiol. 1989 Oct;3(4):353-5.

No abstract available.

On clinically relevant differences and shifted null hypotheses.

Methods of information in medicine

Victor N.
PMID: 3670099
Methods Inf Med. 1987 Jul;26(3):109-16.

No abstract available.

A simple method for the estimation of interaction bias in crossover studies.

Journal of clinical pharmacology

Cleophas TJ.
PMID: 2243151
J Clin Pharmacol. 1990 Nov;30(11):1036-40. doi: 10.1002/j.1552-4604.1990.tb03591.x.

The crossover trial is considered the most powerful means of determining the efficacy of new drugs. However this study design is frequently invalidated by treatment-by-period interaction. If, for example, the effect of the first treatment period carries on into...

[Biomedical researches: for whom? for what? how?].

Annales medico-psychologiques

Brochier T, Pascalis JG, Theret L.
PMID: 2092598
Ann Med Psychol (Paris). 1990 Jun-Jul;148(6):598-9.

The law of December 20th 1988 provides for the protection of those people who lend themselves to clinical research, both patients and healthy subjects. The ex-expert clinicians are confronted with new drugs and protocols of experimentation enacted by industry....

[Good clinical practices. Point of view of the university hospital].

La Revue de medecine interne

Bader JP.
PMID: 3809775
Rev Med Interne. 1986 Nov;11-3.

For clinical investigators, usually on the staff of university hospitals, the setting up in France of a good clinical practices system will no doubt improve the quality of clinical trials in that country. It remains that the investigator's responsibility...

[How to read reports on clinical trials of drugs. II].

Casopis lekaru ceskych

Horácek J.
PMID: 3731219
Cas Lek Cesk. 1986 Jul 04;125(27):835-6.

No abstract available.

Surrogate endpoints: a basis for a rational approach.

European journal of clinical pharmacology

Boissel JP, Collet JP, Moleur P, Haugh M.
PMID: 1425885
Eur J Clin Pharmacol. 1992;43(3):235-44. doi: 10.1007/BF02333016.

In clinical trials, the clinical endpoint is often replaced by an intermediate endpoint, known in some instances as a "surrogate" endpoint. The reasons for the substitution are often both practical and financial. At present, no theoretical basis or practical...

[The pyramids of cardiology].

Giornale italiano di cardiologia

Masoni A.
PMID: 3732712
G Ital Cardiol. 1986 Mar;16(3):191-5.

No abstract available.

Healthy volunteers, risk, and research.

Drug intelligence & clinical pharmacy

Powell JR.
PMID: 3769765
Drug Intell Clin Pharm. 1986 Oct;20(10):776-7. doi: 10.1177/106002808602001007.

No abstract available.

[Type 1, 2 and 3 errors].

Nordisk medicin

Forrest M, Andersen B.
PMID: 3831940
Nord Med. 1985;100(10):272-4.

No abstract available.

Loss of power from an optimistic alternative hypothesis.

Statistics in medicine

Blumenson LE.
PMID: 3368672
Stat Med. 1988 Apr;7(4):457-66. doi: 10.1002/sim.4780070402.

In the planning of a clinical trial to compare the proportion of responses to two treatments one determines the sample size to yield the desired power of achieving a significant difference at a pre-selected type I error under the...

Showing 1 to 12 of 2348 entries