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Lack of expression of tumor-suppressor genes in human malignant glioma cell lines.


Godbout R, Miyakoshi J, Dobler KD, Andison R, Matsuo K, Allalunis-Turner MJ, Takebe H, Day RS.
PMID: 1501894
Oncogene. 1992 Sep;7(9):1879-84.

Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and...

A complex translocation involving chromosomes 3,11, and 14 with an interstitial deletion, del(14) (q13q22) in a child with congenital glaucoma and cleft lip and palate.

Birth defects original article series

Buchanan PD, Rao KW, Doerr CL, Aylsworth AS.
PMID: 728587
Birth Defects Orig Artic Ser. 1978;14(6):317-22.

No abstract available.

Interstitial deletion of the long arm of chromosome 11: report of a case and review of the literature.

The Japanese journal of human genetics

Wakazono A, Masuno M, Yamaguchi S, Tsubouchi K, Kondo N, Orii T.
PMID: 1472705
Jpn J Hum Genet. 1992 Sep;37(3):229-34. doi: 10.1007/BF01900717.

A 12-month-old female infant with developmental delay, growth retardation, and dysmorphic features including dolichocephaly, telecanthus, ptosis, flat nasal bridge, anteverted nares, high-arched palate, carp-shaped mouth, micro-retrognathia, and low-set and posteriorly rotated ears was found to have an interstitial deletion...

Construction of a dihydrofolate reductase-deficient mutant of Escherichia coli by gene replacement.

Journal of bacteriology

Howell EE, Foster PG, Foster LM.
PMID: 2838456
J Bacteriol. 1988 Jul;170(7):3040-5. doi: 10.1128/jb.170.7.3040-3045.1988.
Free PMC Article

The dihydrofolate reductase (fol) gene in Escherichia coli has been deleted and replaced by a selectable marker. Verification of the delta fol::kan strain has been accomplished using genetic and biochemical criteria, including Southern analysis of the chromosomal DNA. The...

Structure of the gene encoding phosphoribosylpyrophosphate synthetase (prsA) in Salmonella typhimurium.

Journal of bacteriology

Bower SG, Hove-Jensen B, Switzer RL.
PMID: 2838463
J Bacteriol. 1988 Jul;170(7):3243-8. doi: 10.1128/jb.170.7.3243-3248.1988.
Free PMC Article

The Salmonella typhimurium gene prsA, which encodes phosphoribosylpyrophosphate synthetase, has been cloned, and the nucleotide sequence has been determined. The amino acid sequence derived from the S. typhimurium gene is 99% identical to the derived Escherichia coli sequence and...

A deletion hot spot in the Duchenne muscular dystrophy gene.


Wapenaar MC, Kievits T, Hart KA, Abbs S, Blonden LA, den Dunnen JT, Grootscholten PM, Bakker E, Verellen-Dumoulin C, Bobrow M.
PMID: 2900805
Genomics. 1988 Feb;2(2):101-8. doi: 10.1016/0888-7543(88)90090-0.

We have made a detailed study of a deletion hot spot in the distal half of the Duchenne muscular dystrophy (DMD) gene, using intragenic probe P20 (DXS269), isolated by a hybrid cell-mediated cloning procedure. P20 detects 16% deletions in...

Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11.


Spurr NK, Gough AC, Gosden J, Rout D, Porteous DJ, van Heyningen V, Docherty AJ.
PMID: 2900807
Genomics. 1988 Feb;2(2):119-27. doi: 10.1016/0888-7543(88)90093-6.

Collagenase and stromelysin are two metalloproteinases produced mainly by connective tissue cells and involved in the breakdown of the extracellular matrix. cDNA clones for both of these genes have been isolated and sequencing has shown them to be closely...

Two regions within the human IL-2 gene promoter are important for inducible IL-2 expression.

Journal of immunology (Baltimore, Md. : 1950)

Williams TM, Eisenberg L, Burlein JE, Norris CA, Pancer S, Yao D, Burger S, Kamoun M, Kant JA.
PMID: 2838551
J Immunol. 1988 Jul 15;141(2):662-6.

We have examined regulatory domains of the human IL-2 gene promoter by transfection and transient expression of rDNA constructs in which the chloramphenicol acetyl transferase gene shows T cell-specific inducible expression and cyclosporin A-mediated inhibition when placed downstream of...

The tRNAGlu2 gene in the rrnB operon of E. coli is a prerequisite for correct RNase III processing in vitro.

Nucleic acids research

Szymkowiak C, Reynolds RL, Chamberlin MJ, Wagner R.
PMID: 3047674
Nucleic Acids Res. 1988 Aug 25;16(16):7885-99. doi: 10.1093/nar/16.16.7885.
Free PMC Article

RNase III cleaves precursor 16S RNA and precursor 23S RNA from the ribosomal RNA transcript. In vitro transcription experiments, using plasmids with the rrnB operon truncated in the 16S RNA and with various deletions in the spacer tRNA region,...

Truncated gag-related proteins are produced by large deletion mutants of Rous sarcoma virus and form virus particles.

Journal of virology

Voynow SL, Coffin JM.
PMID: 2989562
J Virol. 1985 Jul;55(1):79-85. doi: 10.1128/JVI.55.1.79-85.1985.
Free PMC Article

Large deletion (LD) mutants of Prague strain Rous sarcoma virus subgroup B (PrB), derived by serial undiluted passage through chicken (C/E) cells, contain two deletions relative to wild-type virus. One of these joins gag sequences in the p12 coding...

Evolutionary variants of Rous sarcoma virus: large deletion mutants do not result from homologous recombination.

Journal of virology

Voynow SL, Coffin JM.
PMID: 2989561
J Virol. 1985 Jul;55(1):67-78. doi: 10.1128/JVI.55.1.67-78.1985.
Free PMC Article

Large deletion (LD) mutants of Prague strain Rous sarcoma virus, subgroup B (PrB), derived by serial undiluted passage through chicken (C/E) cells, were isolated and characterized. Individual LD viruses were initially isolated by cloning in soft agar of infected,...

[Long-arm deletion of chromosome 1: 46,XY, del (1) (Q42) (author's transl)].

Anales espanoles de pediatria

Molina M, Santolaya JM, Saitua G, Hernández M.
PMID: 727605
An Esp Pediatr. 1978 Oct;11(10):729-32.

A case of long-arm deletion of chromosome No. 1: 46,XY, del (1) (q42) is reported. From the revised bibliography only two cases are comparable cytogenetically, not so phenotypically. The usefulness of the recent banding techniques in the precise diagnosis...

Showing 1 to 12 of 23490 entries