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Association of tyrosine kinase p56lck with CD4 inhibits the induction of growth through the alpha beta T-cell receptor.

Haughn L, Gratton S, Caron L, Sékaly RP, Veillette A, Julius M.
PMID: 1322497
Nature. 1992 Jul 23;358(6384):328-31. doi: 10.1038/358328a0.

The membrane glycoprotein CD4 enhances antigen-mediated activation of T cells restricted by class II molecules of the major histocompatibility complex (MHC). This positive function has been attributed to the protein tyrosine kinase p56lck (ref. 4), which is noncovalently associated...

[Consensus early treatment with zidovudine].

van Everdingen JJ, Lange JM.
PMID: 1922483
Ned Tijdschr Geneeskd. 1991 Aug 24;135(34):1547-50.

The aim was to reach national consensus on the moment early treatment with the antiretroviral drug zidovudine should be started and on the dosing schedule to be used. On the initiative and under the auspices of the National AIDS...

Endometrial T-lymphocyte subset infiltration during the ovine estrous cycle and early pregnancy.

Segerson EC, Matterson PM, Gunsett FC.
PMID: 1720461
J Reprod Immunol. 1991 Sep;20(3):221-36. doi: 10.1016/0165-0378(91)90048-u.

T-lymphocytes were quantitated within luminal, stromal and glandular areas of ovine endometrium. In experiment 1, ovariectomized (OVX), estrus (E) and day 13 (D13) ewes (six/group) received 500 micrograms of phytohemagglutinin (PHA) or vehicle in ligated right and left uterine...

Virus burden in human immunodeficiency virus type 1-infected children: relationship to disease status and effect of antiviral therapy.

Srugo I, Brunell PA, Chelyapov NV, Ho DD, Alam M, Israele V.
PMID: 2034499
Pediatrics. 1991 Jun;87(6):921-5.

The human immunodeficiency virus type 1 (HIV-1) was isolated from the plasma and peripheral blood mononuclear cells (PBMCs) from each of 21 infected children. The mean titers in plasma were 7 and 165 tissue culture-infective doses per milliliter in...

Preparation and characterization of conjugates of recombinant CD4 and deglycosylated ricin A chain using different cross-linkers.

Ghetie V, Till MA, Ghetie MA, Tucker T, Porter J, Patzer EJ, Richardson JA, Uhr JW, Vitetta ES.
PMID: 2095203
Bioconjug Chem. 1990 Jan-Feb;1(1):24-31. doi: 10.1021/bc00001a003.

In a previous study, we have demonstrated that conjugates containing soluble, recombinant human CD4 (rCD4) and the deglycosylated form of ricin A chain (dgA) (rCD4-dgA) effectively kill a human T cell line infected with the human immunodeficiency virus (HIV)...

Overproduction and dissection of proteins by the expression-cassette polymerase chain reaction.

MacFerrin KD, Terranova MP, Schreiber SL, Verdine GL.
PMID: 2408046
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1937-41. doi: 10.1073/pnas.87.5.1937.
Free PMC Article

We report an efficient, general approach for the construction of protein-overproducing strains of Escherichia coli. The method, expression-cassette polymerase chain reaction (ECPCR), allows the insertion of virtually any contiguous coding sequence between sequences that direct high-level protein biosynthesis in...

Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry.

Carr SA, Hemling ME, Folena-Wasserman G, Sweet RW, Anumula K, Barr JR, Huddleston MJ, Taylor P.
PMID: 2592374
J Biol Chem. 1989 Dec 15;264(35):21286-95.
Free Article

The primary structure of a soluble form of the CD4 receptor (sCD4) expressed in Chinese hamster ovary cells has been confirmed by mass spectrometric peptide mapping and and tandem mass spectrometry. These studies corroborated 95% of the 369-amino acid-long...

Mucosal mast cell responses are not required for protection against infection with the murine nematode parasite Trichuris muris.

Koyama K, Ito Y.
PMID: 10607287
Parasite Immunol. 2000 Jan;22(1):13-20. doi: 10.1046/j.1365-3024.2000.00270.x.

The involvement of mucosal mast cells (MMC) in protection against infection with the murine nematode parasite Trichuris muris was studied in genetically mast cell-deficient WBB6F1-W/Wv mice and their normal littermates WBB6F1-+/+ mice. Expulsion of T. muris worms occurred in...

Expression, purification, and characterization of a murine CD4 fragment containing the first two N-terminal domains.

Wang WC, Yeh AA.
PMID: 9398598
Biochem Biophys Res Commun. 1997 Nov 26;240(3):530-5. doi: 10.1006/bbrc.1997.7688.

CD4 is a membrane glycoprotein on T lymphocytes that binds to the same peptide:major histocompatibility complex (MHC) class II molecules recognized by the antigen-specific T cell receptor (TcR). Recent evidence supports the importance of coaggregation of CD4 and TcR...

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.

Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K, Waguri M, Imagawa A, Tamura S, Inada M.
PMID: 8227346
J Clin Invest. 1993 Nov;92(5):2313-22. doi: 10.1172/JCI116835.

We examined pancreas biopsy specimens from 18 newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients to elucidate the mechanism underlying beta cell destruction. Pancreas islets were seen in all patients and insulitis in eight patients. Infiltrating mononuclear cells consisted of...

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance.

Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S.
PMID: 11812990
Nat Immunol. 2002 Feb;3(2):135-42. doi: 10.1038/ni759. Epub 2002 Jan 22.

CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor...

Staining of cell surface human CD4 with 2'-F-pyrimidine-containing RNA aptamers for flow cytometry.

Davis KA, Lin Y, Abrams B, Jayasena SD.
PMID: 9705498
Nucleic Acids Res. 1998 Sep 01;26(17):3915-24. doi: 10.1093/nar/26.17.3915.

We have used recombinant human CD4 presented on beads as an affinity matrix to screen a 2'-F-pyrimidine-containing RNA library with a complexity of approximately 10(14) molecules. Affinity-selected aptamers bind recombinant CD4 with low nanomolar equilibrium dissociation constants. These high-affinity...

Showing 1 to 12 of 70 entries