Haughn L, Gratton S, Caron L, Sékaly RP, Veillette A, Julius M.
Nature. 1992 Jul 23;358(6384):328-31. doi: 10.1038/358328a0.
The membrane glycoprotein CD4 enhances antigen-mediated activation of T cells restricted by class II molecules of the major histocompatibility complex (MHC). This positive function has been attributed to the protein tyrosine kinase p56lck (ref. 4), which is noncovalently associated...
van Everdingen JJ, Lange JM.
Ned Tijdschr Geneeskd. 1991 Aug 24;135(34):1547-50.
The aim was to reach national consensus on the moment early treatment with the antiretroviral drug zidovudine should be started and on the dosing schedule to be used. On the initiative and under the auspices of the National AIDS...
Segerson EC, Matterson PM, Gunsett FC.
J Reprod Immunol. 1991 Sep;20(3):221-36. doi: 10.1016/0165-0378(91)90048-u.
T-lymphocytes were quantitated within luminal, stromal and glandular areas of ovine endometrium. In experiment 1, ovariectomized (OVX), estrus (E) and day 13 (D13) ewes (six/group) received 500 micrograms of phytohemagglutinin (PHA) or vehicle in ligated right and left uterine...
Srugo I, Brunell PA, Chelyapov NV, Ho DD, Alam M, Israele V.
Pediatrics. 1991 Jun;87(6):921-5.
The human immunodeficiency virus type 1 (HIV-1) was isolated from the plasma and peripheral blood mononuclear cells (PBMCs) from each of 21 infected children. The mean titers in plasma were 7 and 165 tissue culture-infective doses per milliliter in...
Ghetie V, Till MA, Ghetie MA, Tucker T, Porter J, Patzer EJ, Richardson JA, Uhr JW, Vitetta ES.
Bioconjug Chem. 1990 Jan-Feb;1(1):24-31. doi: 10.1021/bc00001a003.
In a previous study, we have demonstrated that conjugates containing soluble, recombinant human CD4 (rCD4) and the deglycosylated form of ricin A chain (dgA) (rCD4-dgA) effectively kill a human T cell line infected with the human immunodeficiency virus (HIV)...
MacFerrin KD, Terranova MP, Schreiber SL, Verdine GL.
Proc Natl Acad Sci U S A. 1990 Mar;87(5):1937-41. doi: 10.1073/pnas.87.5.1937.
Free PMC Article
We report an efficient, general approach for the construction of protein-overproducing strains of Escherichia coli. The method, expression-cassette polymerase chain reaction (ECPCR), allows the insertion of virtually any contiguous coding sequence between sequences that direct high-level protein biosynthesis in...
Carr SA, Hemling ME, Folena-Wasserman G, Sweet RW, Anumula K, Barr JR, Huddleston MJ, Taylor P.
J Biol Chem. 1989 Dec 15;264(35):21286-95.
The primary structure of a soluble form of the CD4 receptor (sCD4) expressed in Chinese hamster ovary cells has been confirmed by mass spectrometric peptide mapping and and tandem mass spectrometry. These studies corroborated 95% of the 369-amino acid-long...
Koyama K, Ito Y.
Parasite Immunol. 2000 Jan;22(1):13-20. doi: 10.1046/j.1365-3024.2000.00270.x.
The involvement of mucosal mast cells (MMC) in protection against infection with the murine nematode parasite Trichuris muris was studied in genetically mast cell-deficient WBB6F1-W/Wv mice and their normal littermates WBB6F1-+/+ mice. Expulsion of T. muris worms occurred in...
Wang WC, Yeh AA.
Biochem Biophys Res Commun. 1997 Nov 26;240(3):530-5. doi: 10.1006/bbrc.1997.7688.
CD4 is a membrane glycoprotein on T lymphocytes that binds to the same peptide:major histocompatibility complex (MHC) class II molecules recognized by the antigen-specific T cell receptor (TcR). Recent evidence supports the importance of coaggregation of CD4 and TcR...
Itoh N, Hanafusa T, Miyazaki A, Miyagawa J, Yamagata K, Yamamoto K, Waguri M, Imagawa A, Tamura S, Inada M.
J Clin Invest. 1993 Nov;92(5):2313-22. doi: 10.1172/JCI116835.
We examined pancreas biopsy specimens from 18 newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients to elucidate the mechanism underlying beta cell destruction. Pancreas islets were seen in all patients and insulitis in eight patients. Infiltrating mononuclear cells consisted of...
Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S.
Nat Immunol. 2002 Feb;3(2):135-42. doi: 10.1038/ni759. Epub 2002 Jan 22.
CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor...
Davis KA, Lin Y, Abrams B, Jayasena SD.
Nucleic Acids Res. 1998 Sep 01;26(17):3915-24. doi: 10.1093/nar/26.17.3915.
We have used recombinant human CD4 presented on beads as an affinity matrix to screen a 2'-F-pyrimidine-containing RNA library with a complexity of approximately 10(14) molecules. Affinity-selected aptamers bind recombinant CD4 with low nanomolar equilibrium dissociation constants. These high-affinity...