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Showing 1 to 12 of 37 entries
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Identification of the Tolfenamic Acid Binding Pocket in PrbP from .

Frontiers in microbiology

Pan L, Gardner CL, Pagliai FA, Gonzalez CF, Lorca GL.
PMID: 28878750
Front Microbiol. 2017 Aug 23;8:1591. doi: 10.3389/fmicb.2017.01591. eCollection 2017.

In

The preliminary study of effects of tolfenamic Acid on cell proliferation, cell apoptosis, and intracellular collagen deposition in keloid fibroblasts in vitro.

Dermatology research and practice

Yi D, Bihl J, Newman MS, Chen Y, Simman R.
PMID: 25328513
Dermatol Res Pract. 2014;2014:736957. doi: 10.1155/2014/736957. Epub 2014 Sep 22.

Keloid scarring is a fibroproliferative disorder due to the accumulation of collagen type I. Tolfenamic acid (TA), a nonsteroidal anti-inflammatory drug, has been found to potentially affect the synthesis of collagen in rats. In this preliminary study, we aimed...

Assay of tolfenamic acid and its metabolites by liquid chromatography on dynamically modified silica: application in pharmacokinetics.

Journal of pharmaceutical and biomedical analysis

Hansen SH, Pedersen SB.
PMID: 16867632
J Pharm Biomed Anal. 1986;4(1):69-82. doi: 10.1016/0731-7085(86)80025-5.

An LC method able to separate all known metabolites of tolfenamic acid was developed. It was applied to characterize the metabolic profiles after single and multiple peroral doses of tolfenamic acid to volunteers. Up to 80% of the dose,...

Can the study of self-assembly in solution lead to a good model for the nucleation pathway? The case of tolfenamic acid.

Chemical science

Du W, Cruz-Cabeza AJ, Woutersen S, Davey RJ, Yin Q.
PMID: 29511513
Chem Sci. 2015 Jun 01;6(6):3515-3524. doi: 10.1039/c5sc00522a. Epub 2015 Apr 17.

To further our understanding of the role of solution chemistry in directing nucleation processes new experimental and computational data are presented on the solution and crystallisation chemistry of tolfenamic acid (TA), a benchmark polymorphic compound. With these, and previously...

Isomorphism: 'molecular similarity to crystal structure similarity' in multicomponent forms of analgesic drugs tolfenamic and mefenamic acid.

IUCrJ

Ranjan S, Devarapalli R, Kundu S, Saha S, Deolka S, Vangala VR, Reddy CM.
PMID: 32148846
IUCrJ. 2020 Jan 07;7:173-183. doi: 10.1107/S205225251901604X. eCollection 2020 Mar 01.

The non-steroidal anti-inflammatory drugs mefenamic acid (MFA) and tolfenamic acid (TFA) have a close resemblance in their molecular scaffold, whereby a methyl group in MFA is substituted by a chloro group in TFA. The present study demonstrates the isomorphous...

Effect of Selected Nonsteroidal Anti-inflammatory Drugs on the Viability of Canine Osteosarcoma Cells of the D-17 Line: .

Journal of veterinary research

Poradowski D, Obmińska-Mrukowicz B.
PMID: 31572821
J Vet Res. 2019 Sep 13;63(3):399-403. doi: 10.2478/jvetres-2019-0051. eCollection 2019 Sep.

INTRODUCTION: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in veterinary medicine. They are used in pain control and in anti-inflammatory and antipyretic therapies. Some NSAIDs, MATERIAL AND METHODS: The viability of the cells was evaluated using the MTT assay....

Experimental safety testing shows that the NSAID tolfenamic acid is not toxic to Gyps vultures in India at concentrations likely to be encountered in cattle carcasses.

The Science of the total environment

Chandramohan S, Mallord JW, Mathesh K, Sharma AK, Mahendran K, Kesavan M, Gupta R, Chutia K, Pawde A, Prakash NV, Ravichandran P, Saikia D, Shringarpure R, Timung A, Galligan TH, Green RE, Prakash VM.
PMID: 34861305
Sci Total Environ. 2021 Nov 30;809:152088. doi: 10.1016/j.scitotenv.2021.152088. Epub 2021 Nov 30.

Population declines of Gyps vultures across the Indian subcontinent were caused by unintentional poisoning by the non-steroidal anti-inflammatory drug (NSAID) diclofenac. Subsequently, a number of other NSAIDs have been identified as toxic to vultures, while one, meloxicam, is safe...

Experimental safety testing shows that the NSAID tolfenamic acid is not toxic to Gyps vultures in India at concentrations likely to be encountered in cattle carcasses.

The Science of the total environment

Chandramohan S, Mallord JW, Mathesh K, Sharma AK, Mahendran K, Kesavan M, Gupta R, Chutia K, Pawde A, Prakash NV, Ravichandran P, Saikia D, Shringarpure R, Timung A, Galligan TH, Green RE, Prakash VM.
PMID: 34861305
Sci Total Environ. 2021 Nov 30;809:152088. doi: 10.1016/j.scitotenv.2021.152088. Epub 2021 Nov 30.

Population declines of Gyps vultures across the Indian subcontinent were caused by unintentional poisoning by the non-steroidal anti-inflammatory drug (NSAID) diclofenac. Subsequently, a number of other NSAIDs have been identified as toxic to vultures, while one, meloxicam, is safe...

Next generation sequencing and functional pathway analysis to understand the mechanism of action of copper-tolfenamic acid against pancreatic cancer cells.

Process biochemistry (Barking, London, England)

Hurtado M, Prokai L, Sankpal UT, Levesque B, Maram R, Chhabra J, Brown DT, Gurung RK, Holder AA, Vishwanatha JK, Basha R.
PMID: 32719579
Process Biochem. 2020 Feb;89:155-164. doi: 10.1016/j.procbio.2019.10.022. Epub 2019 Oct 30.

Anti-cancer activity of tolfenamic acid (TA) in preclinical models for pancreatic cancer (PaCa) is well established. Since the dosage for anti-cancer actions of TA is rather high, we recently demonstrated that IC

Method Optimization: Analysis of Benzbromarone and Tolfenamic Acid in Citrus Tissues and Soil Using Liquid Chromatography Coupled With Triple-Quadrupole Mass Spectrometry.

Frontiers in plant science

Zhang D, da Silva DR, Garrett TJ, Gonzalez CF, Lorca GL.
PMID: 32210995
Front Plant Sci. 2020 Mar 06;11:222. doi: 10.3389/fpls.2020.00222. eCollection 2020.

Herein, an analytical method was developed for extraction and quantification of benzbromarone and tolfenamic acid in citrus and soil matrices using liquid-liquid extraction followed by liquid chromatography-triple quadrupole-tandem mass spectrometry analysis. The compounds were extracted using 0.1% formic acid...

In the Context of Polymorphism: Accurate Measurement, and Validation of Solubility Data.

Crystal growth & design

Vázquez Marrero VR, Berríos CP, Dios Rodríguez L, Stelzer T, López-Mejías V.
PMID: 32863778
Cryst Growth Des. 2019;19(7):4101-4108. doi: 10.1021/acs.cgd.9b00529. Epub 2019 Jun 07.

Solubility measurements for polymorphic compounds are often accompanied by solvent-mediated phase transformations. In this study, solubility measurements from undersaturated solutions are employed to investigate the solubility of the two most stable polymorphs of flufenamic acid (FFA forms I and...

Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway.

Journal of clinical biochemistry and nutrition

Kim JH, Jung JY, Shim JH, Kim J, Choi KH, Shin JA, Choi ES, Lee SO, Chintharlapalli S, Kwon KH, Leem DH, Cho NP, Cho SD.
PMID: 20664734
J Clin Biochem Nutr. 2010 Jul;47(1):74-80. doi: 10.3164/jcbn.10-02. Epub 2010 Jun 17.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to inhibit cancer growth by inhibiting the activity of cyclooxygenase (COX). However, there is increasing evidence that the COX-independent pathway may be also involved in the inhibitory effect of NSAIDs against tumor progression....

Showing 1 to 12 of 37 entries