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Showing 1 to 12 of 62 entries
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Spotlight on paroxetine in psychiatric disorders in adults.

CNS drugs

Wagstaff AJ, Cheer SM, Matheson AJ, Ormrod D, Goa KL.
PMID: 12027788
CNS Drugs. 2002;16(6):425-34. doi: 10.2165/00023210-200216060-00006.

Paroxetine is a selective serotonin reuptake inhibitor (SSRI), with antidepressant and anxiolytic activity. In 6- to 24-week well designed trials, oral paroxetine 10 to 50 mg/day was significantly more effective than placebo, at least as effective as tricyclic antidepressants...

Paroxetine: an update of its use in psychiatric disorders in adults.

Drugs

Wagstaff AJ, Cheer SM, Matheson AJ, Ormrod D, Goa KL.
PMID: 11893234
Drugs. 2002;62(4):655-703. doi: 10.2165/00003495-200262040-00010.

Paroxetine is a selective serotonin reuptake inhibitor (SSRI), with antidepressant and anxiolytic activity. In 6- to 24-week well designed trials, oral paroxetine 10 to 50 mg/day was significantly more effective than placebo, at least as effective as tricyclic antidepressants...

Stability of benzodiazepines in hair after prolonged exposure to chlorinated water.

Forensic science international

Morini L, Pozzi F, Groppi A.
PMID: 28750304
Forensic Sci Int. 2017 Sep;278:217-220. doi: 10.1016/j.forsciint.2017.07.003. Epub 2017 Jul 14.

INTRODUCTION: An in vitro study on authentic positive samples was carried out, aiming the evaluation of the effect of chlorinated water on benzodiazepines in hair. Two subjects exposed to chlorinated water for several consecutive times were also investigated.METHOD: Seven...

Insomnia in children: when are hypnotics indicated?.

Paediatric drugs

Younus M, Labellarte MJ.
PMID: 12038875
Paediatr Drugs. 2002;4(6):391-403. doi: 10.2165/00128072-200204060-00006.

Insomnia in children is a nonspecific impairing symptom that may be the result of normal developmental changes, psychosocial duress, a sleep disorder, a psychiatric disorder, other medical disorders, substance misuse, or an adverse effect of medication. Careful clinical assessment...

Understanding the pharmacokinetics of anxiolytic drugs.

Expert opinion on drug metabolism & toxicology

Altamura AC, Moliterno D, Paletta S, Maffini M, Mauri MC, Bareggi S.
PMID: 23330992
Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):423-40. doi: 10.1517/17425255.2013.759209. Epub 2013 Jan 21.

INTRODUCTION: Anxiety disorders are considered the most common mental disorders and they can increase the risk for comorbid mood and substance use disorders, significantly contributing to the global burden of disease. For this reason, anxiolytics are the most prescribed...

[Antagonism with flumazenil of sedation by benzodiazepine during loco-regional anesthesia].

Minerva anestesiologica

Campisi M, Iseppi D, Stacca R, Tassi A, Laganà G.
PMID: 1980354
Minerva Anestesiol. 1990 Sep;56(9):913-5.

No abstract available.

Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat.

Research communications in chemical pathology and pharmacology

Conti I, Tridico RV, Caccia S.
PMID: 2109343
Res Commun Chem Pathol Pharmacol. 1990 Jan;67(1):87-99.

In vivo (delorazepam clearance) and in vitro (monooxygenase activity markers) alterations in drug metabolism and the extent of enzyme induction of the hepatic cytochrome P-450 system were evaluated after oral administration of delorazepam (2.5, 25 and 150 mg/kg) for...

Some behavioral effects of chlorodesmethyldiazepam and lorazepam.

Polish journal of pharmacology and pharmacy

Kostowski W, Płaźnik A, Puciłowski O, Trzaskowska E, Lipińska T.
PMID: 6127668
Pol J Pharmacol Pharm. 1981;33(6):597-602.

Two benzodiazepine derivatives, chlorodesmethyldiazepam (CDD) and lorazepam (LOR) were compared in rats and mice in some behavioral tests. Both compounds similarly depressed audiogenic seizures, facilitated the behavior suppressed by punishment (conflict test) and produced muscle relaxant and sedative effects...

Determination of delorazepam in urine by solid-phase microextraction coupled to high performance liquid chromatography.

Journal of pharmaceutical and biomedical analysis

Aresta A, Monaci L, Zambonin CG.
PMID: 12039639
J Pharm Biomed Anal. 2002 Jun 01;28(5):965-72. doi: 10.1016/s0731-7085(02)00012-2.

An SPME-HPLC-UV method for the determination of delorazepam, a representative benzodiazepine, in spiked human urine samples was developed for the first time. The performances of two commercially available fibers, a carbowax/templated resin (Carbowax/TPR-100) and a polydimethylsiloxane/divinylbenzene (PDMS/DVB), were compared,...

SPME-LC with UV detection to study delorazepam-serum albumin interactions.

Journal of pharmaceutical and biomedical analysis

Zambonin CG, Aresta A.
PMID: 12093523
J Pharm Biomed Anal. 2002 Jul 31;29(5):895-900. doi: 10.1016/s0731-7085(02)00217-0.

Solid phase microextraction coupled to high performance liquid chromatography with UV detection (SPME/LC-UV) has been employed to study the binding of delorazepam to human serum albumin (HSA) and bovine serum albumin (BSA). The procedure could also be potentially extended...

Sensitivity of auditory lateralization and temporal order tests to benzodiazepines.

Audiology : official organ of the International Society of Audiology

Bosatra A, Vertua R, Poli P.
PMID: 6812558
Audiology. 1982;21(5):400-8. doi: 10.3109/00206098209072754.

The responses to tests of auditory lateralization and temporal order to the administration of desmethyldiazepam (DMDZ) and of chlorodesmethyldiazepam (Cl-DMDZ) have been investigated. Therapeutic doses of these two benzodiazepines were used. We have tested four groups of 10 healthy...

Plasma levels of chlorodesmethyldiazepam in humans.

Biopharmaceutics & drug disposition

Dal Bo L, Marcucci F, Mussini E, Perbellini D, Castellani A, Fresia P.
PMID: 6778522
Biopharm Drug Dispos. 1980 Jan-Mar;1(3):123-6. doi: 10.1002/bdd.2510010306.

Chlorodesmethyldiazepam (I) concentrations were followed for 72 h in the plasma of four volunteers given 2 mg of the drug orally. The drug appears to be well absorbed, reaching peak plasma levels of 20--30 ng ml-1 1--2 h after...

Showing 1 to 12 of 62 entries