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Showing 1 to 12 of 397 entries
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Effects of zidovudine therapy in minority and other subpopulations with early HIV infection

Minority STEM training

Fischl MA.
GSID: JlMtZqyywIcJ
S Lagakos, MA Fischl, DS Stein, L Lim, P Volberding - JAMA, 1991 - jamanetwork.com

Objective. —The purpose of this study was to determine whether the beneficial effects of zidovudine seen overall in two recently completed placebo-controlled clinical trials are also …

Zidovudine improves psoriasis in human immunodeficiency virus—positive males

STEM and males

[No authors listed]
GSID: eos-UXVZqbEJ
M Duvic, MM Crane, M Conant… - Archives of …, 1994 - jamanetwork.com

Background and Design: Patients with human immunodeficiency virus (HIV) infection can develop severe psoriasis, which is difficult to treat using conventional therapy. Anecdotal case …

Clinical manifestations, management and therapy of HIV infection in children.

Bailliere's clinical obstetrics and gynaecology

Kaoma FM, Scott GB.
PMID: 1633655
Baillieres Clin Obstet Gynaecol. 1992 Mar;6(1):149-64. doi: 10.1016/s0950-3552(05)80123-3.

Perinatal infection accounts for the majority of cases of HIV infection in children both in developed and developing countries. Transmission may occur in utero, intrapartum or postpartum as a result of breast-feeding. The actual risk of transmission through breast-feeding...

Treatment-limiting toxicities associated withnucleoside analogue reverse transcriptase inhibitor therapy: A prospective, observational study.

Current therapeutic research, clinical and experimental

Palacios R, Santos J, Camino X, Arazo P, Torres Perea R, Echevarrfa S, Ribera E, Sánchez de la Rosa R, Moreno Guillen S.
PMID: 24672118
Curr Ther Res Clin Exp. 2005 Mar;66(2):117-29. doi: 10.1016/j.curtheres.2005.04.002.

BACKGROUND: The Recover Study is an ongoing, prospective study designed 10 to assess toxicity associated with the use of nucleoside analogue reverse transcriptase inhibitors (NRTIs) (stavudine, zidovudine, lamivudine, didanosine, abacavir) in HIV-1-infected patients receiving highly active antiretroviral therapy (HAART)...

AZT recommended for all HIV sufferers.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)

[No authors listed]
PMID: 27523543
Nurs Stand. 1991 Oct 23;6(5):15. doi: 10.7748/ns.6.5.15.s20.

Zidovudine has been recommended for all patients with HIV symptoms, although the long-term benefits and toxicity of early AZT treatment are not known.

Intracellular pharmacokinetic study of zidovudine and its phosphorylated metabolites.

Acta pharmaceutica Sinica. B

Mu L, Zhou R, Tang F, Liu X, Li S, Xie F, Xie X, Peng J, Yu P.
PMID: 27006900
Acta Pharm Sin B. 2016 Mar;6(2):158-62. doi: 10.1016/j.apsb.2015.10.002. Epub 2015 Dec 21.

Zidovudine (AZT), the first drug approved by the US Food and Drug Administration for the treatment of human immunodeficiency virus (HIV) infection, is metabolized in the host cells to 5'-AZT triphosphate (AZT-TP) which inhibits HIV reverse transcriptase. As the...

Cost-effectiveness analysis of antiretroviral therapy in a cohort of HIV-infected patients starting first-line highly active antiretroviral therapy during 6 years of observation.

Patient related outcome measures

Maggiolo F, Colombo GL, Di Matteo S, Bruno GM, Astuti N, Di Filippo E, Masini G, Bernardini C.
PMID: 25733942
Patient Relat Outcome Meas. 2015 Feb 17;6:53-60. doi: 10.2147/PROM.S63586. eCollection 2015.

OBJECTIVES: Costs may play a role in deciding how and when to start highly active antiretroviral therapy (HAART) in a naïve patient. The aim of the present study was to assess the cost- effectiveness of treatment with HAART in...

DDI and liver tests in HIV-1 seropositive haemophiliacs.

Haemophilia : the official journal of the World Federation of Hemophilia

Shopnick RI, Brettler DB, Forand P, McDONALD M.
PMID: 27214617
Haemophilia. 1997 Jan;3(1):35-8. doi: 10.1046/j.1365-2516.1997.00056.x.

Many patients with haemophilia who are HIV-1 seropositive are co-infected with the hepatitis C virus with variable degrees of underlying liver disease. To evaluate whether the use of the antiretroviral agent Dideoxyinosine (DDI) causes worsening of hepatic dysfunction as...

Dilated cardiomyopathy in a zidovudine-treated AIDS patient.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology

d'Amati G, Kwan W, Lewis W.
PMID: 25990428
Cardiovasc Pathol. 1992 Oct-Dec;1(4):317-20. doi: 10.1016/1054-8807(92)90042-M.

The pathogenesis of dilated cardiomyopathy in acquired immunodeficiency syndrome (AIDS) is poorly understood. We report a case of an HIV-positive, 45-year-old homosexual male treated with high-dose azidothymidine (AZT, 1,200 mg/day) for two years prior to development of AIDS. He...

Role of Human Organic Cation Transporter 1 (hOCT1) Polymorphisms in Lamivudine (3TC) Uptake and Drug-Drug Interactions.

Frontiers in pharmacology

Arimany-Nardi C, Minuesa G, Keller T, Erkizia I, Koepsell H, Martinez-Picado J, Pastor-Anglada M.
PMID: 27445813
Front Pharmacol. 2016 Jun 24;7:175. doi: 10.3389/fphar.2016.00175. eCollection 2016.

Lamivudine (3TC), a drug used in the treatment of HIV infection, needs to cross the plasma membrane to exert its therapeutic action. Human Organic cation transporter 1 (hOCT1), encoded by the SLC22A1 gene, is the transporter responsible for its...

The PHACS SMARTT Study: Assessment of the Safety of In Utero Exposure to Antiretroviral Drugs.

Frontiers in immunology

Van Dyke RB, Chadwick EG, Hazra R, Williams PL, Seage GR.
PMID: 27242802
Front Immunol. 2016 May 23;7:199. doi: 10.3389/fimmu.2016.00199. eCollection 2016.

The Surveillance Monitoring for ART Toxicities (SMARTT) cohort of the Pediatric HIV/AIDS Cohort Study includes over 3,500 HIV-exposed but uninfected infants and children at 22 sites in the US, including Puerto Rico. The goal of the study is to...

Occupational Exposure to HIV in an Urban University Hospital Setting.

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Roberts RB, Lincoff AS, Frankel RE.
PMID: 11098192
Braz J Infect Dis. 1999 Apr;3(2):50-62.

In response to the potential transmission of the human immunodeficiency virus in a hospital setting, an occupational exposure assessment program was established at a New York City university hospital in 1990. During the first year, 322 potential exposures to...

Showing 1 to 12 of 397 entries