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Genetic polymorphisms of the drug-metabolizing enzyme CYP2C19 in the Uyghur population in northwest China.

Xenobiotica; the fate of foreign compounds in biological systems

Jin T, Zhang M, Yang H, Geng T, Zhang N, Feng T, Ma Y, Yuan D, Kang L.
PMID: 26526657
Xenobiotica. 2016 Jul;46(7):634-640. doi: 10.3109/00498254.2015.1102986. Epub 2015 Nov 02.

1. CYP2C19 is a clinically important enzyme and is involved in the metabolism of approximately 10% of drugs used in daily clinical practice. Previous studies mainly focused on Chinese Han populations or other ethnic groups, little is known about...

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Jin T, Zhang M, Yang H, et al. Genetic polymorphisms of the drug-metabolizing enzyme CYP2C19 in the Uyghur population in northwest China. Xenobiotica. 2015;46(7):634-640doi: 10.3109/00498254.2015.1102986.
Jin, T., Zhang, M., Yang, H., Geng, T., Zhang, N., Feng, T., Ma, Y., Yuan, D., & Kang, L. (2016). Genetic polymorphisms of the drug-metabolizing enzyme CYP2C19 in the Uyghur population in northwest China. Xenobiotica; the fate of foreign compounds in biological systems, 46(7), 634-640. https://doi.org/10.3109/00498254.2015.1102986
Jin, Tianbo, et al. "Genetic polymorphisms of the drug-metabolizing enzyme CYP2C19 in the Uyghur population in northwest China." Xenobiotica; the fate of foreign compounds in biological systems vol. 46,7 (2016): 634-640. doi: https://doi.org/10.3109/00498254.2015.1102986
Jin T, Zhang M, Yang H, Geng T, Zhang N, Feng T, Ma Y, Yuan D, Kang L. Genetic polymorphisms of the drug-metabolizing enzyme CYP2C19 in the Uyghur population in northwest China. Xenobiotica. 2016 Jul;46(7):634-640. doi: 10.3109/00498254.2015.1102986. Epub 2015 Nov 02. PMID: 26526657.
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Professor John William Gorrod PhD, DSc, MPS(hon), FKC, FSP, FRCPath, 1931-2015.

Xenobiotica; the fate of foreign compounds in biological systems

Smith M, Patterson L.
PMID: 30179080
Xenobiotica. 2016 Jul;46(7):571-572. doi: 10.3109/00498254.2015.1130333.

No abstract available.

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Smith M, Patterson L. Professor John William Gorrod PhD, DSc, MPS(hon), FKC, FSP, FRCPath, 1931-2015. Xenobiotica. 2016;46(7):571-572doi: 10.3109/00498254.2015.1130333.
Smith, M., & Patterson, L. (2016). Professor John William Gorrod PhD, DSc, MPS(hon), FKC, FSP, FRCPath, 1931-2015. Xenobiotica; the fate of foreign compounds in biological systems, 46(7), 571-572. https://doi.org/10.3109/00498254.2015.1130333
Smith, Maurice, and Patterson, Laurence. "Professor John William Gorrod PhD, DSc, MPS(hon), FKC, FSP, FRCPath, 1931-2015." Xenobiotica; the fate of foreign compounds in biological systems vol. 46,7 (2016): 571-572. doi: https://doi.org/10.3109/00498254.2015.1130333
Smith M, Patterson L. Professor John William Gorrod PhD, DSc, MPS(hon), FKC, FSP, FRCPath, 1931-2015. Xenobiotica. 2016 Jul;46(7):571-572. doi: 10.3109/00498254.2015.1130333. PMID: 30179080.
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The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein.

Xenobiotica; the fate of foreign compounds in biological systems

Svennebring A.
PMID: 30179078
Xenobiotica. 2016 Jul;46(7):659-663. doi: 10.3109/00498254.2015.1104562. Epub 2015 Nov 02.

1. Øie-Tozer's model can be used to derive changes in the distribution of drugs in relation to changes in the concentration of drug binding plasma proteins. 2. Concerns have been raised that the model is invalid for this purpose...

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Svennebring A. The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein. Xenobiotica. 2015;46(7):659-663doi: 10.3109/00498254.2015.1104562.
Svennebring, A. (2016). The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein. Xenobiotica; the fate of foreign compounds in biological systems, 46(7), 659-663. https://doi.org/10.3109/00498254.2015.1104562
Svennebring, Andreas. "The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein." Xenobiotica; the fate of foreign compounds in biological systems vol. 46,7 (2016): 659-663. doi: https://doi.org/10.3109/00498254.2015.1104562
Svennebring A. The usefulness of Øie-Tozer's model in deriving pharmacokinetic changes in response to changes in the concentration of drug-binding plasma protein. Xenobiotica. 2016 Jul;46(7):659-663. doi: 10.3109/00498254.2015.1104562. Epub 2015 Nov 02. PMID: 30179078.
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Pharmacokinetics of isoforskolin after administration via different routes in guinea pigs.

Xenobiotica; the fate of foreign compounds in biological systems

Feng T, Li Y, Chen J, Chen Y, Huang J, Weng W.
PMID: 26523445
Xenobiotica. 2016 Jul;46(7):620-626. doi: 10.3109/00498254.2015.1099082. Epub 2015 Nov 02.

1. The objective of this study was to characterize the pharmacokinetics of isoforskolin after oral, intraperitoneal and intravenous administration, as well as to compare bioavailability. 2. Isoforskolin was administered to guinea pigs at a dose of 2 mg/kg. Plasma...

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Feng T, Li Y, Chen J, et al. Pharmacokinetics of isoforskolin after administration via different routes in guinea pigs. Xenobiotica. 2015;46(7):620-626doi: 10.3109/00498254.2015.1099082.
Feng, T., Li, Y., Chen, J., Chen, Y., Huang, J., & Weng, W. (2016). Pharmacokinetics of isoforskolin after administration via different routes in guinea pigs. Xenobiotica; the fate of foreign compounds in biological systems, 46(7), 620-626. https://doi.org/10.3109/00498254.2015.1099082
Feng, Tingting, et al. "Pharmacokinetics of isoforskolin after administration via different routes in guinea pigs." Xenobiotica; the fate of foreign compounds in biological systems vol. 46,7 (2016): 620-626. doi: https://doi.org/10.3109/00498254.2015.1099082
Feng T, Li Y, Chen J, Chen Y, Huang J, Weng W. Pharmacokinetics of isoforskolin after administration via different routes in guinea pigs. Xenobiotica. 2016 Jul;46(7):620-626. doi: 10.3109/00498254.2015.1099082. Epub 2015 Nov 02. PMID: 26523445.
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Optimal pH 8.5 to 9 for the Hydrolysis of Vixotrigine and Other Basic Substrates of Carboxylesterase-1 in Human Liver Microsomes.

Xenobiotica; the fate of foreign compounds in biological systems

Johnson JL, Huang J, Rooney M, Gu C.
PMID: 34904522
Xenobiotica. 2021 Dec 14;1-22. doi: 10.1080/00498254.2021.2018629. Epub 2021 Dec 14.

Vixotrigine is a voltage- and use-dependent sodium channel blocker under investigation for the potential treatment of neuropathic pain. One of the major

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Johnson JL, Huang J, Rooney M, et al. Optimal pH 8.5 to 9 for the Hydrolysis of Vixotrigine and Other Basic Substrates of Carboxylesterase-1 in Human Liver Microsomes. Xenobiotica. 2021;1-22doi: 10.1080/00498254.2021.2018629.
Johnson, J. L., Huang, J., Rooney, M., & Gu, C. (2021). Optimal pH 8.5 to 9 for the Hydrolysis of Vixotrigine and Other Basic Substrates of Carboxylesterase-1 in Human Liver Microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1-22. https://doi.org/10.1080/00498254.2021.2018629
Johnson, Joshua L, et al. "Optimal pH 8.5 to 9 for the Hydrolysis of Vixotrigine and Other Basic Substrates of Carboxylesterase-1 in Human Liver Microsomes." Xenobiotica; the fate of foreign compounds in biological systems vol. (2021): 1-22. doi: https://doi.org/10.1080/00498254.2021.2018629
Johnson JL, Huang J, Rooney M, Gu C. Optimal pH 8.5 to 9 for the Hydrolysis of Vixotrigine and Other Basic Substrates of Carboxylesterase-1 in Human Liver Microsomes. Xenobiotica. 2021 Dec 14;1-22. doi: 10.1080/00498254.2021.2018629. Epub 2021 Dec 14. PMID: 34904522.
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[No title available]

Xenobiotica; the fate of foreign compounds in biological systems

Takahashi Y, Narumi K, Nadai T, Ueda H, Yamamura T, Furugen A, Kobayashi M.
PMID: 34396892
Xenobiotica. 2021 Nov;51(11):1318-1325. doi: 10.1080/00498254.2021.1969480. Epub 2021 Aug 24.

Organic anion-transporting polypeptide (OATP) 2B1 plays a critical role in the intestinal absorption of substrate drugs. Apple juice reportedly interacts with OATP2B1 substrate drugs. The purpose of this study was to investigate the effect of two apple polyphenols, phloretin...

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Takahashi Y, Narumi K, Nadai T, et al. . Xenobiotica. 2021;51(11):1318-1325doi: 10.1080/00498254.2021.1969480.
Takahashi, Y., Narumi, K., Nadai, T., Ueda, H., Yamamura, T., Furugen, A., & Kobayashi, M. (2021). . Xenobiotica; the fate of foreign compounds in biological systems, 51(11), 1318-1325. https://doi.org/10.1080/00498254.2021.1969480
Takahashi, Yuka, et al. "." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,11 (2021): 1318-1325. doi: https://doi.org/10.1080/00498254.2021.1969480
Takahashi Y, Narumi K, Nadai T, Ueda H, Yamamura T, Furugen A, Kobayashi M. . Xenobiotica. 2021 Nov;51(11):1318-1325. doi: 10.1080/00498254.2021.1969480. Epub 2021 Aug 24. PMID: 34396892.
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Preclinical Pharmacokinetics and Metabolism of MAK683, a Clinical Stage Selective Oral Embryonic Ectoderm Development (EED) Inhibitor for Cancer Treatment.

Xenobiotica; the fate of foreign compounds in biological systems

Zhang JYJ, Zhang J, Kiffe M, Walles M, Jin Y, Blanz J, Dayer J, Sanchez A, Zhang C, Zhang L, Huang Y, Oyang C.
PMID: 34761729
Xenobiotica. 2021 Nov 11;1-48. doi: 10.1080/00498254.2021.2005852. Epub 2021 Nov 11.

1. MAK683 (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine) is a potent and orally bioavailable EED inhibitor for the potential treatment in oncology. Pharmacokinetics (PK) in preclinical species are characterized by low to moderate plasma clearances, high oral exposure and moderate to high oral bioavailability...

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Zhang JYJ, Zhang J, Kiffe M, et al. Preclinical Pharmacokinetics and Metabolism of MAK683, a Clinical Stage Selective Oral Embryonic Ectoderm Development (EED) Inhibitor for Cancer Treatment. Xenobiotica. 2021;1-48doi: 10.1080/00498254.2021.2005852.
Zhang, J. Y. J., Zhang, J., Kiffe, M., Walles, M., Jin, Y., Blanz, J., Dayer, J., Sanchez, A., Zhang, C., Zhang, L., Huang, Y., & Oyang, C. (2021). Preclinical Pharmacokinetics and Metabolism of MAK683, a Clinical Stage Selective Oral Embryonic Ectoderm Development (EED) Inhibitor for Cancer Treatment. Xenobiotica; the fate of foreign compounds in biological systems, 1-48. https://doi.org/10.1080/00498254.2021.2005852
Zhang, Ji Yue Jeff, et al. "Preclinical Pharmacokinetics and Metabolism of MAK683, a Clinical Stage Selective Oral Embryonic Ectoderm Development (EED) Inhibitor for Cancer Treatment." Xenobiotica; the fate of foreign compounds in biological systems vol. (2021): 1-48. doi: https://doi.org/10.1080/00498254.2021.2005852
Zhang JYJ, Zhang J, Kiffe M, Walles M, Jin Y, Blanz J, Dayer J, Sanchez A, Zhang C, Zhang L, Huang Y, Oyang C. Preclinical Pharmacokinetics and Metabolism of MAK683, a Clinical Stage Selective Oral Embryonic Ectoderm Development (EED) Inhibitor for Cancer Treatment. Xenobiotica. 2021 Nov 11;1-48. doi: 10.1080/00498254.2021.2005852. Epub 2021 Nov 11. PMID: 34761729.
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Metabolic activation of zolmitriptan mediated by CYP2D6.

Xenobiotica; the fate of foreign compounds in biological systems

Han L, Jia Y, Zhao Y, Sun C, Zhao M, Peng Y, Zheng J.
PMID: 34096834
Xenobiotica. 2021 Nov;51(11):1292-1302. doi: 10.1080/00498254.2021.1938290. Epub 2021 Nov 03.

Zolmitriptan (ZOL), a member of triptans, has been used for the treatment of migraine with definite therapeutic effects. However, several cases of liver injury associated with ZOL have been reported and the underlying mechanisms remain unclear.The present study aimed...

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Han L, Jia Y, Zhao Y, et al. Metabolic activation of zolmitriptan mediated by CYP2D6. Xenobiotica. 2021;51(11):1292-1302doi: 10.1080/00498254.2021.1938290.
Han, L., Jia, Y., Zhao, Y., Sun, C., Zhao, M., Peng, Y., & Zheng, J. (2021). Metabolic activation of zolmitriptan mediated by CYP2D6. Xenobiotica; the fate of foreign compounds in biological systems, 51(11), 1292-1302. https://doi.org/10.1080/00498254.2021.1938290
Han, Lingling, et al. "Metabolic activation of zolmitriptan mediated by CYP2D6." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,11 (2021): 1292-1302. doi: https://doi.org/10.1080/00498254.2021.1938290
Han L, Jia Y, Zhao Y, Sun C, Zhao M, Peng Y, Zheng J. Metabolic activation of zolmitriptan mediated by CYP2D6. Xenobiotica. 2021 Nov;51(11):1292-1302. doi: 10.1080/00498254.2021.1938290. Epub 2021 Nov 03. PMID: 34096834.
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Referee acknowledgements.

Xenobiotica; the fate of foreign compounds in biological systems

[No authors listed]
PMID: 32301396
Xenobiotica. 2020 Jun;50(6):741-745. doi: 10.1080/00498254.2020.1752545.

No abstract available.

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Referee acknowledgements. Xenobiotica. 2020;50(6):741-745doi: 10.1080/00498254.2020.1752545.
(2020). Referee acknowledgements. Xenobiotica; the fate of foreign compounds in biological systems, 50(6), 741-745. https://doi.org/10.1080/00498254.2020.1752545
"Referee acknowledgements." Xenobiotica; the fate of foreign compounds in biological systems vol. 50,6 (2020): 741-745. doi: https://doi.org/10.1080/00498254.2020.1752545
Referee acknowledgements. Xenobiotica. 2020 Jun;50(6):741-745. doi: 10.1080/00498254.2020.1752545. PMID: 32301396.
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Metabolic conversion of β-pinene to β-ionone in rats.

Xenobiotica; the fate of foreign compounds in biological systems

Aloum L, Semreen MH, Al-Tel TH, Al-Hroub H, Mousa M, Jayaraj RL, Alefishat E, Adem A, Petroianu GA.
PMID: 34931580
Xenobiotica. 2021 Dec 27;1-9. doi: 10.1080/00498254.2021.2020376. Epub 2021 Dec 27.

Exposure to or ingestion of turpentine can alter the scent of urine, conferring it a flowery, violet-like scent. Turpentine's effect on urine was initially noticed after its use either as medicine or as a preservative in winemaking. Regardless of...

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Aloum L, Semreen MH, Al-Tel TH, et al. Metabolic conversion of β-pinene to β-ionone in rats. Xenobiotica. 2021;1-9doi: 10.1080/00498254.2021.2020376.
Aloum, L., Semreen, M. H., Al-Tel, T. H., Al-Hroub, H., Mousa, M., Jayaraj, R. L., Alefishat, E., Adem, A., & Petroianu, G. A. (2021). Metabolic conversion of β-pinene to β-ionone in rats. Xenobiotica; the fate of foreign compounds in biological systems, 1-9. https://doi.org/10.1080/00498254.2021.2020376
Aloum, Lujain, et al. "Metabolic conversion of β-pinene to β-ionone in rats." Xenobiotica; the fate of foreign compounds in biological systems vol. (2021): 1-9. doi: https://doi.org/10.1080/00498254.2021.2020376
Aloum L, Semreen MH, Al-Tel TH, Al-Hroub H, Mousa M, Jayaraj RL, Alefishat E, Adem A, Petroianu GA. Metabolic conversion of β-pinene to β-ionone in rats. Xenobiotica. 2021 Dec 27;1-9. doi: 10.1080/00498254.2021.2020376. Epub 2021 Dec 27. PMID: 34931580.
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Metabolic activation of deferiprone mediated by CYP2A6.

Xenobiotica; the fate of foreign compounds in biological systems

Zheng X, Wang X, Ding Z, Li W, Peng Y, Zheng J.
PMID: 34006188
Xenobiotica. 2021 Nov;51(11):1282-1291. doi: 10.1080/00498254.2021.1931729. Epub 2021 Oct 28.

Deferiprone (DFP) is a metal chelating agent generally used to treat patients with thalassaemia, due to iron overload in clinical settings.Studies have revealed that long-term use of DFP can induce hepatotoxicity, however, mechanisms of its toxic action remain unclear....

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Zheng X, Wang X, Ding Z, et al. Metabolic activation of deferiprone mediated by CYP2A6. Xenobiotica. 2021;51(11):1282-1291doi: 10.1080/00498254.2021.1931729.
Zheng, X., Wang, X., Ding, Z., Li, W., Peng, Y., & Zheng, J. (2021). Metabolic activation of deferiprone mediated by CYP2A6. Xenobiotica; the fate of foreign compounds in biological systems, 51(11), 1282-1291. https://doi.org/10.1080/00498254.2021.1931729
Zheng, Xiaojiao, et al. "Metabolic activation of deferiprone mediated by CYP2A6." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,11 (2021): 1282-1291. doi: https://doi.org/10.1080/00498254.2021.1931729
Zheng X, Wang X, Ding Z, Li W, Peng Y, Zheng J. Metabolic activation of deferiprone mediated by CYP2A6. Xenobiotica. 2021 Nov;51(11):1282-1291. doi: 10.1080/00498254.2021.1931729. Epub 2021 Oct 28. PMID: 34006188.
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[Genetically engineered V79 Chinese hamster cells for stable expression of xenobiotics metabolising enzymes].

ALTEX

Doehmer J, Barrenscheen M, Dogra S, Edigkaufer M, Giatt H, Oesch F, Platt KL, Seidel A, Wölfel C.
PMID: 11178563
ALTEX. 1991;8(2):52-65.

V79 derived Chinese hamster cells lines with specific xenobiotica metabolising functions were constructed by gene technological means. The significance of these cell lines as a test system in toxicology and pharmacology has been demonstrated by the evaluation of metabolite...

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Doehmer J, Barrenscheen M, Dogra S, et al. Die gentechnologische Konstruktion von V79 Chinesische Hamsterzellen zur stabilen Expression von Fremdstoff-metabolisierenden Enzymen. [Genetically engineered V79 Chinese hamster cells for stable expression of xenobiotics metabolising enzymes]. ALTEX. 1991;8(2):52-65
Doehmer, J., Barrenscheen, M., Dogra, S., Edigkaufer, M., Giatt, H., Oesch, F., Platt, K. L., Seidel, A., & Wölfel, C. (1991). Die gentechnologische Konstruktion von V79 Chinesische Hamsterzellen zur stabilen Expression von Fremdstoff-metabolisierenden Enzymen. [Genetically engineered V79 Chinese hamster cells for stable expression of xenobiotics metabolising enzymes]. ALTEX, 8(2), 52-65.
Doehmer, J., et al. "Die gentechnologische Konstruktion von V79 Chinesische Hamsterzellen zur stabilen Expression von Fremdstoff-metabolisierenden Enzymen." [Genetically engineered V79 Chinese hamster cells for stable expression of xenobiotics metabolising enzymes]. ALTEX vol. 8,2 (1991): 52-65.
Doehmer J, Barrenscheen M, Dogra S, Edigkaufer M, Giatt H, Oesch F, Platt KL, Seidel A, Wölfel C. Die gentechnologische Konstruktion von V79 Chinesische Hamsterzellen zur stabilen Expression von Fremdstoff-metabolisierenden Enzymen. [Genetically engineered V79 Chinese hamster cells for stable expression of xenobiotics metabolising enzymes]. ALTEX. 1991;8(2):52-65. PMID: 11178563.
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Showing 1 to 12 of 73 entries