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Showing 1 to 12 of 96 entries
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Guarana (.

Toxicology research

Arantes LP, Peres TV, Chen P, Caito S, Aschner M, Soares FA.
PMID: 28316775
Toxicol Res (Camb). 2016 Nov 01;5(6):1629-1638. doi: 10.1039/C6TX00161K. Epub 2016 Aug 24.

The influence of routine guarana (

One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines.

Chemistry Central journal

El-Kalyoubi SA, Fayed EA, Abdel-Razek AS.
PMID: 29086842
Chem Cent J. 2017 Jul 19;11(1):66. doi: 10.1186/s13065-017-0294-0.

BACKGROUND: Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum activities including anticancer, antiviral as well as antimicrobial activities.RESULTS: A newly synthesized compounds pyrimido[4,5-b][1,...

Effects of alternative steeping methods on composition, antioxidant property and colour of green, black and oolong tea infusions.

Journal of food science and technology

Lantano C, Rinaldi M, Cavazza A, Barbanti D, Corradini C.
PMID: 26604404
J Food Sci Technol. 2015 Dec;52(12):8276-83. doi: 10.1007/s13197-015-1971-4. Epub 2015 Jul 29.

Cold water steeping is reported to maximise tea health benefits, but requires long infusion time. In this work, the employment of a brief hot infusion step followed by ice addition was evaluated. The comparison of this innovative method with...

Effective dimensional reduction algorithm for eigenvalue problems for thin elastic structures: a paradigm in three dimensions.

Proceedings of the National Academy of Sciences of the United States of America

Ovtchinnikov EE, Xanthis LS.
PMID: 10655469
Proc Natl Acad Sci U S A. 2000 Feb 01;97(3):967-71. doi: 10.1073/pnas.97.3.967.

We present a methodology for the efficient numerical solution of eigenvalue problems of full three-dimensional elasticity for thin elastic structures, such as shells, plates and rods of arbitrary geometry, discretized by the finite element method. Such problems are solved...

Synthesis of 2-substituted 9-oxa-guanines {5-aminooxazolo[5,4-d]pyrimidin-7(6H)-ones} and 9-oxa-2-thio-xanthines {5-mercaptooxazolo[5,4-d]pyrimidin-7(6H)-ones}.

Beilstein journal of organic chemistry

Mandal S, Li WT, Bai Y, Robertus JD, Kerwin SM.
PMID: 18941495
Beilstein J Org Chem. 2008;4:26. doi: 10.3762/bjoc.4.26. Epub 2008 Jul 25.

Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives. In particular, 5-aminooxazolo[5,4-d]pyrimidine-7(6H)-ones (9-oxa-guanines) have been shown to inhibit ricin. The...

Adverse pulmonary effects of topical Beta blockers used in the treatment of glaucoma.

Journal of glaucoma

Avorn J, Glynn RJ, Gurwitz JH, Bohn RL, Monane M, Everitt DE, Gilden D, Choodnovskiy I.
PMID: 19920512
J Glaucoma. 1993;2(3):158-65.

We conducted a case-control study to measure the risk of pulmonary side effects following the use of topical glaucoma medications, particularly the beta blockers, and to identify patients at highest risk for such side effects. Patients over age 55...

Xanthines in respiratory diseases.

Canadian family physician Medecin de famille canadien

Mazza JA.
PMID: 21286561
Can Fam Physician. 1982 Oct;28:1799-803.

Xanthines have been widely used for almost 50 years to treat bronchospastic conditions. They have a number of pharmacological properties, but the clinical applications are limited as bronchodilators. Current applications include intravenous preparations for acute asthma and prophylactically for...

Assessing the association between omalizumab and arteriothrombotic events through spontaneous adverse event reporting.

Journal of asthma and allergy

Ali AK, Hartzema AG.
PMID: 22690127
J Asthma Allergy. 2012;5:1-9. doi: 10.2147/JAA.S29811. Epub 2012 May 03.

BACKGROUND: Omalizumab is a monoclonal antibody, indicated for the treatment of severe allergic asthma. In Europe, there have been concerns about the cardiovascular safety of omalizumab. The objective of this study was to analyze the association between omalizumab and...

Degradation of caffeine and related methylxanthines bySerratia marcescens isolated from soil under coffee cultivation.

Microbial ecology

Mazzafera P, Olsson O, Sandberg G.
PMID: 24185743
Microb Ecol. 1996 Mar;31(2):199-207. doi: 10.1007/BF00167865.

A strain of Serratia marcescens showing the ability to degrade caffeine and other methylxanthines was isolated from soil under coffee cultivation. Growth was observed only with xanthines methylated at the 7 position (caffeine, 1,3,7-dimethylxanthine; paraxanthine, 1,7-dimethylxanthine; theobromine, 3,7-dimethylxanthine and...

Novel 8-heterocyclyl xanthine derivatives in drug development - an update.

Expert opinion on drug discovery

Baraldi PG, Fruttarolo F, Tabrizi MA, Romagnoli R, Preti D.
PMID: 23496127
Expert Opin Drug Discov. 2007 Sep;2(9):1161-83. doi: 10.1517/17460441.2.9.1161.

Naturally occurring methyl xanthines, especially caffeine and theophylline, have been widely investigated for their pharmacological properties as cognition enhancers, bronchodilator agents and mild diuretics. The xanthine core (3,7-dihydro-1H-purine-2,6-dione) has been largely manipulated in the search for selective ligands for...

Activation and Desensitization of Rat A.

Drug development research

Park KS, Hoffmann C, Kim HO, Padgett WL, Daly JW, Brambilla R, Motta C, Abbracchio MP, Jacobson KA.
PMID: 23487508
Drug Dev Res. 1998 Jun 01;44(2):97-105. doi: 10.1002/(SICI)1098-2299(199806/07)44:2/3<97::AID-DDR7>3.0.CO;2-5.

Strategy, Management and Health PolicyVenture Capital Enabling TechnologyPreclinical ResearchPreclinical Development Toxicology, Formulation Drug Delivery, PharmacokineticsClinical Development Phases I-III Regulatory, Quality, ManufacturingPostmarketing Phase IV Xanthine and adenosine derivatives, known to bind to recombinant rat A

Antioxidant activity prediction and classification of some teas using artificial neural networks.

Food chemistry

Cimpoiu C, Cristea VM, Hosu A, Sandru M, Seserman L.
PMID: 25214133
Food Chem. 2011 Aug 01;127(3):1323-8. doi: 10.1016/j.foodchem.2011.01.091. Epub 2011 Jan 28.

In order to characterise and to classify some teas a simple, rapid and economical method based on composition, antioxidant activity and artificial neural networks (ANNs) is proposed. For these purpose two types of ANN based applications have been developed:...

Showing 1 to 12 of 96 entries