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Showing 1 to 12 of 449 entries
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An active Catharanthus roseus desacetoxyvindoline-4-hydroxylase-like gene and its transcriptional regulatory profile.

Botanical studies

Zhou C, Zhang J, Zhao SJ, Hu ZB.
PMID: 28510984
Bot Stud. 2014 Dec;55(1):29. doi: 10.1186/1999-3110-55-29. Epub 2014 Mar 13.

BACKGROUND: Desacetoxyvindoline-4-hydroxylase is a key enzyme in the biosynthesis of vindoline, the important intermediate leading to vinblastine and vincristine in Catharanthus roseus.RESULTS: A d4h-like gene has been isolated from C. roseus CCONCLUSION: These results suggest that d4h-like is closely...

Human antigen R as a predictive marker for response to gemcitabine-based chemotherapy in advanced cisplatin-resistant urothelial cancer.

Oncology letters

Miyata Y, Mitsunari K, Akihiro A, Watanabe SI, Matsuo T, Ohba K, Sakai H.
PMID: 28356963
Oncol Lett. 2017 Feb;13(2):811-818. doi: 10.3892/ol.2016.5484. Epub 2016 Dec 12.

In patients with advanced urothelial cancer (UC), a combination of cisplatin (CDDP) and gemcitabine (GEM) is the most commonly used first-line systematic chemotherapy regimen. Although no standard regime for the treatment of CDDP-resistant UC has been established, GEM-based regimens...

Primary Diffuse Large B-cell Lymphoma Arising in the Tongue Accompanied by Ataxia-telangiectasia: A Case Report.

Journal of clinical and diagnostic research : JCDR

Tomioka H, Kaneoya A, Mochizuki Y, Harada H.
PMID: 26266230
J Clin Diagn Res. 2015 Jun;9(6):ZD25-7. doi: 10.7860/JCDR/2015/12121.6107. Epub 2015 Jun 01.

Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder that is characterized by progressive cerebellar ataxia, telangiectasia, immunodeficiency, and a predisposition to leukemia/lymphoma. Here we report a rare case of lymphoma of the tongue accompanied by AT. Tumour extirpation was...

Bleomycin-induced flagellate dermatitis.

Revista brasileira de hematologia e hemoterapia

Mota GD, Penna AM, Soares RC, Baiocchi OC.
PMID: 25031171
Rev Bras Hematol Hemoter. 2014 Jul-Aug;36(4):297-9. doi: 10.1016/j.bjhh.2014.03.001. Epub 2014 Apr 03.

A 29-year-old woman with stage IVB Hodgkin's lymphoma was treated with doxorubicin, bleomycin, vinblastine, and dacarbazine. Two weeks after the first cycle was completed, she developed pruritic, linear erythematous lesions in a flagellate-like pattern on the trunk, neck and...

Unusual primary osseous Hodgkin's lymphoma: A case report.

Oncology letters

Luo W, Zhang F, Sun J, He H.
PMID: 25621037
Oncol Lett. 2015 Feb;9(2):677-680. doi: 10.3892/ol.2014.2724. Epub 2014 Nov 20.

Hodgkin's lymphoma (HL) is one of the few adult malignancies that most frequently presents with a progressive, painless enlargement of the peripheral lymph nodes. A primary osseous presentation of HL, without lymph node involvement, is extremely rare. The present...

Brain metabolic changes in Hodgkin disease patients following diagnosis and during the disease course: An .

Oncology letters

Chiaravalloti A, Pagani M, Cantonetti M, DI Pietro B, Tavolozza M, Travascio L, DI Biagio D, Danieli R, Schillaci O.
PMID: 25621038
Oncol Lett. 2015 Feb;9(2):685-690. doi: 10.3892/ol.2014.2765. Epub 2014 Dec 03.

The aim of the present study was to investigate brain glucose metabolism in patients with Hodgkin disease (HD) after diagnosis and during chemotherapy treatment. Following the administration of first-line doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy, 74 HD patients...

Anti-cancer potential of flavonoids: recent trends and future perspectives.

3 Biotech

Batra P, Sharma AK.
PMID: 28324424
3 Biotech. 2013 Dec;3(6):439-459. doi: 10.1007/s13205-013-0117-5. Epub 2013 Feb 12.

Cancer is a major public health concern in both developed and developing countries. Several plant-derived anti-cancer agents including taxol, vinblastine, vincristine, the campothecin derivatives, topotecan, irinotecan and etoposide are in clinical use all over the world. Other promising anti-cancer...

The benefit of consolidation radiotherapy to initial disease bulk in patients with advanced Hodgkin's disease who achieved complete remission after standard chemotherapy.

Journal of blood medicine

Bayoumi Y, Al-Homaidi A, Zaidi S, Tailor I, Motiabi I, Alshehri N, Al-Ghazali A, Almudaibigh S.
PMID: 25848329
J Blood Med. 2015 Mar 20;6:87-92. doi: 10.2147/JBM.S69267. eCollection 2015.

BACKGROUND/PURPOSE: The aim of this study was to evaluate the role of consolidation radiotherapy (RT) in advanced-stage Hodgkin's disease (HD) with initial bulky sites after radiological complete remission (CR) or partial response (PR) with positron emission tomography-negative (metabolic CR)...

Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma.

Therapeutic advances in hematology

Sethi T, Nguyen V, Li S, Morgan D, Greer J, Reddy N.
PMID: 28042455
Ther Adv Hematol. 2017 Jan;8(1):13-20. doi: 10.1177/2040620716676256. Epub 2016 Oct 30.

BACKGROUND: Nodular sclerosis Hodgkin lymphoma (NS-HL) is the most common subtype of HL and usually has a good prognosis. A variant of NS, the syncytial variant (SV) has well-established histopathologic features but little is known about its clinical behavior....

CEPP regimen (cyclophosphamide, etoposide, procarbazine and prednisone) as initial treatment for Hodgkin lymphoma patients presenting with severe abnormal liver function.

Biomarker research

Thakar K, Novero A, Das A, Lisinschi A, Mehta B, Ahmed T, Liu D.
PMID: 24991411
Biomark Res. 2014 Jun 23;2:12. doi: 10.1186/2050-7771-2-12. eCollection 2014.

ABVD regimen (doxorubicin, bleomycin, vinblastine and dacarbazine) remains the most commonly used front-line therapy for Hodgkin lymphoma. However, atypical and extranodal presentations present challenges to initial therapy, especially in the presence of renal and liver failure. We hereby present...

Drug-Resistant Urothelial Cancer Cell Lines Display Diverse Sensitivity Profiles to Potential Second-Line Therapeutics.

Translational oncology

Vallo S, Michaelis M, Rothweiler F, Bartsch G, Gust KM, Limbart DM, Rödel F, Wezel F, Haferkamp A, Cinatl J.
PMID: 26055179
Transl Oncol. 2015 Jun;8(3):210-6. doi: 10.1016/j.tranon.2015.04.002.

Combination chemotherapy with gemcitabine and cisplatin in patients with metastatic urothelial cancer of the bladder frequently results in the development of acquired drug resistance. Availability of cell culture models with acquired resistance could help to identify candidate treatments for...

Pattern of CD4 T-lymphocyte Values in Cancer Patients on Cytotoxic Therapy.

Annals of medical and health sciences research

Madu A, Ocheni S, Ibegbulam O, Aguwa E, Madu K.
PMID: 24379998
Ann Med Health Sci Res. 2013 Oct;3(4):498-503. doi: 10.4103/2141-9248.122054.

BACKGROUND: Assessment of patients prior to cytotoxic chemotherapy usually includes absolute neutrophils count. Other cellular markers of susceptibility to infection as well as immunocompetence include the T Helper lymphocyte count. In cancer patients, decrease in these lymphocytes has been...

Showing 1 to 12 of 449 entries