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The Reactome BioMart.

Database : the journal of biological databases and curation

Haw RA, Croft D, Yung CK, Ndegwa N, D'Eustachio P, Hermjakob H, Stein LD.
PMID: 22012987
Database (Oxford). 2011 Oct 19;2011:bar031. doi: 10.1093/database/bar031. Print 2011.

Reactome is an open source, expert-authored, manually curated and peer-reviewed database of reactions, pathways and biological processes. We provide an intuitive web-based user interface to pathway knowledge and a suite of data analysis tools. The Reactome BioMart provides biologists...

Network-Based Predictors of Progression in Head and Neck Squamous Cell Carcinoma.

Frontiers in genetics

Sanati N, Iancu OD, Wu G, Jacobs JE, McWeeney SK.
PMID: 29910823
Front Genet. 2018 May 29;9:183. doi: 10.3389/fgene.2018.00183. eCollection 2018.

The heterogeneity in head and neck squamous cell carcinoma (HNSCC) has made reliable stratification extremely challenging. Behavioral risk factors such as smoking and alcohol consumption contribute to this heterogeneity. To help elucidate potential mechanisms of progression in HNSCC, we...

Author-sourced capture of pathway knowledge in computable form using Biofactoid.

eLife

Wong JV, Franz M, Siper MC, Fong D, Durupinar F, Dallago C, Luna A, Giorgi J, Rodchenkov I, Babur Ö, Bachman JA, Gyori BM, Demir E, Bader GD, Sander C.
PMID: 34860157
Elife. 2021 Dec 03;10. doi: 10.7554/eLife.68292.

Making the knowledge contained in scientific papers machine-readable and formally computable would allow researchers to take full advantage of this information by enabling integration with other knowledge sources to support data analysis and interpretation. Here we describe Biofactoid, a...

Using Reactome to build an autophagy mechanism knowledgebase.

Autophagy

Varusai TM, Jupe S, Sevilla C, Matthews L, Gillespie M, Stein L, Wu G, D'Eustachio P, Metzakopian E, Hermjakob H.
PMID: 32486891
Autophagy. 2021 Jun;17(6):1543-1554. doi: 10.1080/15548627.2020.1761659. Epub 2020 Jun 02.

The 21st century has revealed much about the fundamental cellular process of autophagy. Autophagy controls the catabolism and recycling of various cellular components both as a constitutive process and as a response to stress and foreign material invasion. There...

ReactomeFIViz: a Cytoscape app for pathway and network-based data analysis.

F1000Research

Wu G, Dawson E, Duong A, Haw R, Stein L.
PMID: 25309732
F1000Res. 2014 Jul 01;3:146. doi: 10.12688/f1000research.4431.2. eCollection 2014.

High-throughput experiments are routinely performed in modern biological studies. However, extracting meaningful results from massive experimental data sets is a challenging task for biologists. Projecting data onto pathway and network contexts is a powerful way to unravel patterns embedded...

Annotating cancer variants and anti-cancer therapeutics in reactome.

Cancers

Milacic M, Haw R, Rothfels K, Wu G, Croft D, Hermjakob H, D'Eustachio P, Stein L.
PMID: 24213504
Cancers (Basel). 2012 Nov 08;4(4):1180-211. doi: 10.3390/cancers4041180.

Reactome describes biological pathways as chemical reactions that closely mirror the actual physical interactions that occur in the cell. Recent extensions of our data model accommodate the annotation of cancer and other disease processes. First, we have extended our...

Reactome and the Gene Ontology: Digital convergence of data resources.

Bioinformatics (Oxford, England)

Good BM, Van Auken K, Hill DP, Mi H, Carbon S, Balhoff JP, Albou LP, Thomas PD, Mungall CJ, Blake JA, D'Eustachio P.
PMID: 33964129
Bioinformatics. 2021 May 08; doi: 10.1093/bioinformatics/btab325. Epub 2021 May 08.

MOTIVATION: GO Causal Activity Models (GO-CAMs) assemble individual associations of gene products with cellular components, molecular functions, and biological processes into causally linked activity flow models. Pathway databases such as the Reactome Knowledgebase create detailed molecular process descriptions of...

Author-sourced capture of pathway knowledge in computable form using Biofactoid.

eLife

Wong JV, Franz M, Siper MC, Fong D, Durupinar F, Dallago C, Luna A, Giorgi J, Rodchenkov I, Babur Ö, Bachman JA, Gyori BM, Demir E, Bader GD, Sander C.
PMID: 34860157
Elife. 2021 Dec 03;10. doi: 10.7554/eLife.68292.

Making the knowledge contained in scientific papers machine-readable and formally computable would allow researchers to take full advantage of this information by enabling integration with other knowledge sources to support data analysis and interpretation. Here we describe Biofactoid, a...

Perform Pathway Enrichment Analysis Using ReactomeFIViz.

Methods in molecular biology (Clifton, N.J.)

Haw R, Loney F, Ong E, He Y, Wu G.
PMID: 31583638
Methods Mol Biol. 2020;2074:165-179. doi: 10.1007/978-1-4939-9873-9_13.

Modern large-scale biological data analysis often generates a set of significant genes, frequently associated with scores. Pathway-based approaches are routinely performed to understand the functional contexts of these genes. Reactome is the most comprehensive open-access biological pathway knowledge base,...

Automation of ReactomeFIViz via CyREST API.

F1000Research

Loney F, Wu G.
PMID: 29946442
F1000Res. 2018 May 02;7:531. doi: 10.12688/f1000research.14776.2. eCollection 2018.

Pathway- and network-based approaches project seemingly unrelated genes onto the context of pathways and networks, enhancing the analysis power that cannot be achieved via gene-based approaches. Pathway and network approaches are routinely applied in large-scale data analysis for cancer...

ReactomeFIViz: the Reactome FI Cytoscape app for pathway and network-based data analysis.

F1000Research

Wu G, Dawson E, Duong A, Haw R, Stein L.
PMID: 25309732
F1000Res. 2014 Jul 01;3:146. doi: 10.12688/f1000research.4431.1. eCollection 2014.

High-throughput experiments are routinely performed in modern biological studies. However, extracting meaningful results from massive experimental data sets is a challenging task for biologists. Projecting data onto pathway and network contexts is a powerful way to unravel patterns embedded...

Author-sourced capture of pathway knowledge in computable form using Biofactoid.

eLife

Wong JV, Franz M, Siper MC, Fong D, Durupinar F, Dallago C, Luna A, Giorgi JM, Rodchenkov I, Babur Ö, Bachman JA, Gyori B, Demir E, Bader GD, Sander C.
PMID: 34860157
Elife. 2021 Dec 03;10. doi: 10.7554/eLife.68292. Epub 2021 Dec 03.

Making the knowledge contained in scientific papers machine-readable and formally computable would allow researchers to take full advantage of this information by enabling integration with other knowledge sources to support data analysis and interpretation. Here we describe Biofactoid, a...

Showing 1 to 12 of 15 entries