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Showing 1 to 12 of 1422 entries
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Immunomodulatory effects of the botanical compound LCS101: implications for cancer treatment.

OncoTargets and therapy

Rachmut IH, Samuels N, Melnick SJ, Ramachandran C, Sharabi Y, Pavlovsky A, Maimon Y, Shoham J.
PMID: 23637542
Onco Targets Ther. 2013 Apr 24;6:437-45. doi: 10.2147/OTT.S42038. Print 2013.

OBJECTIVE: To examine the effects of LSC101, a botanical compound, on adaptive and innate immunity.MATERIALS AND METHODS: LCS101 preparations were tested for batch-to-batch consistency using high-performance liquid chromatography. T-cell activation was quantified in murine spleen cells using 3H-thymidine incorporation,...

MMP 9 Gene Promoter Polymorphism in Gastric Cancer.

Indian journal of clinical biochemistry : IJCB

Krishnaveni D, Bhayal AC, Sri Manjari K, Vidyasagar A, Uma Devi M, Ramanna M, Jyothy A, Nallari P, Venkateshwari A.
PMID: 26405384
Indian J Clin Biochem. 2012 Jul;27(3):259-64. doi: 10.1007/s12291-012-0210-2. Epub 2012 Apr 18.

Matrix metalloproteinase-9 (gelatinase B) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C) > thymidine (T) single nucleotide polymorphism (SNP) at position -1562 in the MMP-9 promoter...

Screening glioma stem cells in U251 cells based on the P1 promoter of the CD133 gene.

Oncology letters

Wang X, Chen L, Xiao Z, Wang Y, Liu T, Zhang T, Zhang Y.
PMID: 27698813
Oncol Lett. 2016 Oct;12(4):2457-2462. doi: 10.3892/ol.2016.4966. Epub 2016 Aug 05.

Cluster of differentiation (CD)133 is an important cell surface marker of glioma stem cells (GSCs). The transcription of the CD133 gene is controlled by five alternative promoters (P1, P2, P3, P4 and P5), which are expressed in a tissue-specific...

A Positive Selection for Nucleoside Kinases in E. coli.

PloS one

Shelat NY, Parhi S, Ostermeier M.
PMID: 27677184
PLoS One. 2016 Sep 27;11(9):e0162921. doi: 10.1371/journal.pone.0162921. eCollection 2016.

Engineering heterologous nucleoside kinases inside E. coli is a difficult process due to the integral role nucleosides play in cell division and transcription. Nucleoside analogs are used in many kinase screens that depend on cellular metabolization of the analogs....

Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells.

Stem cells and development

Toro L, Bohovic R, Matuskova M, Smolkova B, Kucerova L.
PMID: 27539058
Stem Cells Dev. 2016 Nov 01;25(21):1640-1651. doi: 10.1089/scd.2016.0064. Epub 2016 Aug 16.

Due to late diagnosis, often recurrence, formation of metastases and resistance to commonly used chemotherapeutics human ovarian carcinoma represents a serious disease with high mortality. Adipose tissue-derived mesenchymal stromal cells (AT-MSC) can serve as vehicles for therapeutic genes and...

Synthesis of dinucleoside acylphosphonites by phosphonodiamidite chemistry and investigation of phosphorus epimerization.

Beilstein journal of organic chemistry

Hersh WH.
PMID: 25815068
Beilstein J Org Chem. 2015 Jan 30;11:184-91. doi: 10.3762/bjoc.11.19. eCollection 2015.

The reaction of the diamidite, (iPr2N)2PH, with acyl chlorides proceeds with the loss of HCl to give the corresponding acyl diamidites, RC(O)P(N(iPr)2)2 (R = Me (7), Ph (9)), without the intervention of sodium to give a phosphorus anion. The...

In vivo imaging of endogenous neural stem cells in the adult brain.

World journal of stem cells

Rueger MA, Schroeter M.
PMID: 25621107
World J Stem Cells. 2015 Jan 26;7(1):75-83. doi: 10.4252/wjsc.v7.i1.75.

The discovery of endogenous neural stem cells (eNSCs) in the adult mammalian brain with their ability to self-renew and differentiate into functional neurons, astrocytes and oligodendrocytes has raised the hope for novel therapies of neurological diseases. Experimentally, those eNSCs...

Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma.

International journal of clinical and experimental medicine

Ji Y, Wu XB, Chen JY, Hu B, Zhu QK, Zhu XF, Zheng MF.
PMID: 26550200
Int J Clin Exp Med. 2015 Aug 15;8(8):12850-7. eCollection 2015.

Patients with esophageal cancer are often diagnosed at advanced stages, leading to poor prognosis. Biomarkers are needed to enable earlier detection as well as to aid in the prediction of prognosis, but to date these tools remain scarce. Thymidine...

Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells.

Physiological reports

Huynh N, Liu KH, Yim M, Shulkes A, Baldwin GS, He H.
PMID: 24963032
Physiol Rep. 2014 Jun 24;2(6). doi: 10.14814/phy2.12048. Print 2014 Jun 01.

Gastrins, including amidated gastrin17 and glycine-extended gastrin17, are important growth factors in colorectal cancer (CRC). The p21-activated kinase 1 (PAK1) plays key roles in cellular processes including proliferation, survival, and motility, and in cell transformation and tumor progression. PAK1...

Pilot study investigating the prognostic significance of thymidine phosphorylase expression in patients with metastatic breast cancer: a single institution retrospective analysis.

OncoTargets and therapy

Tedeschi AL, Eslami Z, Garoufalis E, Saleh RR, Omeroglu A, Altinel G, Ait-Tihyaty M, Jean-Claude B, Mihalcioiu C.
PMID: 25960662
Onco Targets Ther. 2015 Apr 21;8:911-9. doi: 10.2147/OTT.S71089. eCollection 2015.

BACKGROUND: The thymidine phosphorylase (TP) enzyme is expressed in higher levels in cancer tissue when compared with normal tissue. It is involved in the intratumoral activation of widely prescribed pyrimidine-derived antimetabolites such as 5'-deoxy-5-fluorouridine and capecitabine (Xeloda(®)). The purpose...

Improving the safety of cell therapy products by suicide gene transfer.

Frontiers in pharmacology

Jones BS, Lamb LS, Goldman F, Di Stasi A.
PMID: 25505885
Front Pharmacol. 2014 Nov 27;5:254. doi: 10.3389/fphar.2014.00254. eCollection 2014.

Adoptive T-cell therapy can involve donor lymphocyte infusion after allogeneic hematopoietic stem cell transplantation, the administration of tumor infiltrating lymphocyte expanded ex-vivo, or more recently the use of T cell receptor or chimeric antigen receptor redirected T cells. However,...

Vesicular Stomatitis Virus G Glycoprotein and ATRA Enhanced Bystander Killing of Chemoresistant Leukemic Cells by Herpes Simplex Virus Thymidine Kinase/Ganciclovir.

Biomolecules & therapeutics

Hu C, Chen Z, Zhao W, Wei L, Zheng Y, He C, Zeng Y, Yin B.
PMID: 24753816
Biomol Ther (Seoul). 2014 Feb;22(2):114-21. doi: 10.4062/biomolther.2013.112.

Refractoriness of acute myeloid leukemia (AML) cells to chemotherapeutics represents a major clinical barrier. Suicide gene therapy for cancer has been attractive but with limited clinical efficacy. In this study, we investigated the potential application of herpes simplex virus...

Showing 1 to 12 of 1422 entries