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Design of new and potent diethyl thiobarbiturates as urease inhibitors: a computational approach.

Bioinformation

Wadood A, Riaz M, Mulk AU, Khan M, Haleem SA, Shams S, Gul S, Ahmed A, Qasim M, Ali F, Ul-Haq Z.
PMID: 24966538
Bioinformation. 2014 May 20;10(5):299-307. doi: 10.6026/97320630010299. eCollection 2014.

Urease is an important enzyme both in agriculture and medicine research. Strategies based on urease inhibition is critically considered as the first line treatment of infections caused by urease producing bacteria. Since, urease possess agro-chemical and medicinal importance, thus,...

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Wadood A, Riaz M, Mulk AU, et al. Design of new and potent diethyl thiobarbiturates as urease inhibitors: a computational approach. Bioinformation. 2014;10(5):299-307doi: 10.6026/97320630010299.
Wadood, A., Riaz, M., Mulk, A. U., Khan, M., Haleem, S. A., Shams, S., Gul, S., Ahmed, A., Qasim, M., Ali, F., & Ul-Haq, Z. (2014). Design of new and potent diethyl thiobarbiturates as urease inhibitors: a computational approach. Bioinformation, 10(5), 299-307. https://doi.org/10.6026/97320630010299
Wadood, Abdul, et al. "Design of new and potent diethyl thiobarbiturates as urease inhibitors: a computational approach." Bioinformation vol. 10,5 (2014): 299-307. doi: https://doi.org/10.6026/97320630010299
Wadood A, Riaz M, Mulk AU, Khan M, Haleem SA, Shams S, Gul S, Ahmed A, Qasim M, Ali F, Ul-Haq Z. Design of new and potent diethyl thiobarbiturates as urease inhibitors: a computational approach. Bioinformation. 2014 May 20;10(5):299-307. doi: 10.6026/97320630010299. eCollection 2014. PMID: 24966538; PMCID: PMC4070040.
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Inhibition of neutrophil respiratory burst and chemotaxis in vitro by thiopentone but not methohexitone.

Neurosurgical focus

Heine J, Scheinichen D, Jaeger K, Emmendoerffer A, Leuwer M.
PMID: 15099049
Neurosurg Focus. 1997 Jun 15;2(6):e1. doi: 10.3171/foc.1997.2.6.4.

Administration of high-dose barbiturates may be used as an appropriate adjunctive treatment for control of intracranial pressure. The thiobarbiturate, thiopentone, has been reported to increase the rate of nosocomial pulmonary infection. This may be a substance-related effect of thiobarbiturates...

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Heine J, Scheinichen D, Jaeger K, et al. Inhibition of neutrophil respiratory burst and chemotaxis in vitro by thiopentone but not methohexitone. Neurosurg Focus. 1997;2(6):e1doi: 10.3171/foc.1997.2.6.4.
Heine, J., Scheinichen, D., Jaeger, K., Emmendoerffer, A., & Leuwer, M. (1997). Inhibition of neutrophil respiratory burst and chemotaxis in vitro by thiopentone but not methohexitone. Neurosurgical focus, 2(6), e1. https://doi.org/10.3171/foc.1997.2.6.4
Heine, J, et al. "Inhibition of neutrophil respiratory burst and chemotaxis in vitro by thiopentone but not methohexitone." Neurosurgical focus vol. 2,6 (1997): e1. doi: https://doi.org/10.3171/foc.1997.2.6.4
Heine J, Scheinichen D, Jaeger K, Emmendoerffer A, Leuwer M. Inhibition of neutrophil respiratory burst and chemotaxis in vitro by thiopentone but not methohexitone. Neurosurg Focus. 1997 Jun 15;2(6):e1. doi: 10.3171/foc.1997.2.6.4. PMID: 15099049.
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Comparing C2=O and C2=S Barbiturates: Different Hydrogen-Bonding Patterns of Thiobarbiturates in Solution and the Solid State.

International journal of molecular sciences

Li C, Hilgeroth P, Hasan N, Ströhl D, Kressler J, Binder WH.
PMID: 34884482
Int J Mol Sci. 2021 Nov 24;22(23). doi: 10.3390/ijms222312679.

Carbonyl-centered hydrogen bonds with various strength and geometries are often exploited in materials to embed dynamic and adaptive properties, with the use of thiocarbonyl groups as hydrogen-bonding acceptors remaining only scarcely investigated. We herein report a comparative study of...

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Li C, Hilgeroth P, Hasan N, et al. Comparing C2=O and C2=S Barbiturates: Different Hydrogen-Bonding Patterns of Thiobarbiturates in Solution and the Solid State. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222312679.
Li, C., Hilgeroth, P., Hasan, N., Ströhl, D., Kressler, J., & Binder, W. H. (2021). Comparing C2=O and C2=S Barbiturates: Different Hydrogen-Bonding Patterns of Thiobarbiturates in Solution and the Solid State. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222312679
Li, Chenming, et al. "Comparing C2=O and C2=S Barbiturates: Different Hydrogen-Bonding Patterns of Thiobarbiturates in Solution and the Solid State." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222312679
Li C, Hilgeroth P, Hasan N, Ströhl D, Kressler J, Binder WH. Comparing C2=O and C2=S Barbiturates: Different Hydrogen-Bonding Patterns of Thiobarbiturates in Solution and the Solid State. Int J Mol Sci. 2021 Nov 24;22(23). doi: 10.3390/ijms222312679. PMID: 34884482.
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Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.

ACS medicinal chemistry letters

Maurer B, Rumpf T, Scharfe M, Stolfa DA, Schmitt ML, He W, Verdin E, Sippl W, Jung M.
PMID: 24900427
ACS Med Chem Lett. 2012 Oct 06;3(12):1050-3. doi: 10.1021/ml3002709. eCollection 2012 Dec 13.

NAD(+)-dependent histone deacetylases (sirtuins) play important roles in epigenetic regulation but also through nonhistone substrates for other key cellular events and have been linked to the pathogenesis of cancer, neurodegeneration, and metabolic diseases. The subtype Sirt5 has been shown...

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Maurer B, Rumpf T, Scharfe M, et al. Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett. 2012;3(12):1050-3doi: 10.1021/ml3002709.
Maurer, B., Rumpf, T., Scharfe, M., Stolfa, D. A., Schmitt, M. L., He, W., Verdin, E., Sippl, W., & Jung, M. (2012). Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS medicinal chemistry letters, 3(12), 1050-3. https://doi.org/10.1021/ml3002709
Maurer, Benjamin, et al. "Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5." ACS medicinal chemistry letters vol. 3,12 (2012): 1050-3. doi: https://doi.org/10.1021/ml3002709
Maurer B, Rumpf T, Scharfe M, Stolfa DA, Schmitt ML, He W, Verdin E, Sippl W, Jung M. Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett. 2012 Oct 06;3(12):1050-3. doi: 10.1021/ml3002709. eCollection 2012 Dec 13. PMID: 24900427; PMCID: PMC4025838.
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Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates.

Journal of anesthesia

Baek WY, Hatano Y, Nakamura K, Nishiwada M, Mori K.
PMID: 15278659
J Anesth. 1991 Apr;5(2):199-202. doi: 10.1007/s0054010050199.

Responses to thiamylal and thiopental were compared in helical strips of rat thoracic aortas of different ages (5-6, 10-12 and 20-22 weeks old), precontracted partially with phenylephrine or prostaglandin F(2alpha) (PGF(2alpha)). Thiamylal and thiopental, in concentrations of 3 x...

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Baek WY, Hatano Y, Nakamura K, et al. Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates. J Anesth. 1991;5(2):199-202doi: 10.1007/s0054010050199.
Baek, W. Y., Hatano, Y., Nakamura, K., Nishiwada, M., & Mori, K. (1991). Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates. Journal of anesthesia, 5(2), 199-202. https://doi.org/10.1007/s0054010050199
Baek, W Y, et al. "Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates." Journal of anesthesia vol. 5,2 (1991): 199-202. doi: https://doi.org/10.1007/s0054010050199
Baek WY, Hatano Y, Nakamura K, Nishiwada M, Mori K. Age-dependent alterations in the response of isolated rat aortas to thiobarbiturates. J Anesth. 1991 Apr;5(2):199-202. doi: 10.1007/s0054010050199. PMID: 15278659.
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Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS.

Healthcare (Basel, Switzerland)

Huang TH, Lai MC, Chen YS, Huang CW.
PMID: 34828616
Healthcare (Basel). 2021 Nov 18;9(11). doi: 10.3390/healthcare9111570.

BACKGROUND: Status epilepticus (SE) is a neurological emergency and is usually associated with significant morbidity and mortality rates. Several clinical scales have been proposed to predict the clinical outcome of such incidents, including the Status Epilepticus Severity Score (STESS),...

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Huang TH, Lai MC, Chen YS, et al. Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS. Healthcare (Basel). 2021;9(11)doi: 10.3390/healthcare9111570.
Huang, T. H., Lai, M. C., Chen, Y. S., & Huang, C. W. (2021). Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS. Healthcare (Basel, Switzerland), 9(11), . https://doi.org/10.3390/healthcare9111570
Huang, Tzu-Hsin, et al. "Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS." Healthcare (Basel, Switzerland) vol. 9,11 (2021). doi: https://doi.org/10.3390/healthcare9111570
Huang TH, Lai MC, Chen YS, Huang CW. Status Epilepticus Mortality Risk Factors and a Correlation Survey with the Newly Modified STESS. Healthcare (Basel). 2021 Nov 18;9(11). doi: 10.3390/healthcare9111570. PMID: 34828616; PMCID: PMC8622169.
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Bis-thiobarbiturates as Promising Xanthine Oxidase Inhibitors: Synthesis and Biological Evaluation.

Biomedicines

Serrano JL, Lopes D, Reis MJA, Boto REF, Silvestre S, Almeida P.
PMID: 34680559
Biomedicines. 2021 Oct 11;9(10). doi: 10.3390/biomedicines9101443.

Xanthine oxidase (XO) is the enzyme responsible for the conversion of endogenous purines into uric acid. Therefore, this enzyme has been associated with pathological conditions caused by hyperuricemia, such as the disease commonly known as gout. Barbiturates and their...

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Serrano JL, Lopes D, Reis MJA, et al. Bis-thiobarbiturates as Promising Xanthine Oxidase Inhibitors: Synthesis and Biological Evaluation. Biomedicines. 2021;9(10)doi: 10.3390/biomedicines9101443.
Serrano, J. L., Lopes, D., Reis, M. J. A., Boto, R. E. F., Silvestre, S., & Almeida, P. (2021). Bis-thiobarbiturates as Promising Xanthine Oxidase Inhibitors: Synthesis and Biological Evaluation. Biomedicines, 9(10), . https://doi.org/10.3390/biomedicines9101443
Serrano, João L, et al. "Bis-thiobarbiturates as Promising Xanthine Oxidase Inhibitors: Synthesis and Biological Evaluation." Biomedicines vol. 9,10 (2021). doi: https://doi.org/10.3390/biomedicines9101443
Serrano JL, Lopes D, Reis MJA, Boto REF, Silvestre S, Almeida P. Bis-thiobarbiturates as Promising Xanthine Oxidase Inhibitors: Synthesis and Biological Evaluation. Biomedicines. 2021 Oct 11;9(10). doi: 10.3390/biomedicines9101443. PMID: 34680559; PMCID: PMC8533253.
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One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine.

Acta crystallographica. Section C, Structural chemistry

Hützler WM, Egert E, Bolte M.
PMID: 27585936
Acta Crystallogr C Struct Chem. 2016 Sep 01;72:705-15. doi: 10.1107/S205322961601336X. Epub 2016 Aug 26.

A path to new synthons for application in crystal engineering is the replacement of a strong hydrogen-bond acceptor, like a C=O group, with a weaker acceptor, like a C=S group, in doubly or triply hydrogen-bonded synthons. For instance, if...

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Hützler WM, Egert E, Bolte M. One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine. Acta Crystallogr C Struct Chem. 2016;72:705-15doi: 10.1107/S205322961601336X.
Hützler, W. M., Egert, E., & Bolte, M. (2016). One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine. Acta crystallographica. Section C, Structural chemistry, 72705-15. https://doi.org/10.1107/S205322961601336X
Hützler, Wilhelm Maximilian, et al. "One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine." Acta crystallographica. Section C, Structural chemistry vol. 72 (2016): 705-15. doi: https://doi.org/10.1107/S205322961601336X
Hützler WM, Egert E, Bolte M. One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bonded ADA/DAD synthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine. Acta Crystallogr C Struct Chem. 2016 Sep 01;72:705-15. doi: 10.1107/S205322961601336X. Epub 2016 Aug 26. PMID: 27585936.
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The history of barbiturates a century after their clinical introduction.

Neuropsychiatric disease and treatment

López-Muñoz F, Ucha-Udabe R, Alamo C.
PMID: 18568113
Neuropsychiatr Dis Treat. 2005 Dec;1(4):329-43.

The present work offers an analysis of the historical development of the discovery and use of barbiturates in the field of psychiatry and neurology, a century after their clinical introduction. Beginning with the synthesis of malonylurea by von Baeyer...

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López-Muñoz F, Ucha-Udabe R, Alamo C. The history of barbiturates a century after their clinical introduction. Neuropsychiatr Dis Treat. 2005;1(4):329-43
López-Muñoz, F., Ucha-Udabe, R., & Alamo, C. (2005). The history of barbiturates a century after their clinical introduction. Neuropsychiatric disease and treatment, 1(4), 329-43.
López-Muñoz, Francisco, et al. "The history of barbiturates a century after their clinical introduction." Neuropsychiatric disease and treatment vol. 1,4 (2005): 329-43.
López-Muñoz F, Ucha-Udabe R, Alamo C. The history of barbiturates a century after their clinical introduction. Neuropsychiatr Dis Treat. 2005 Dec;1(4):329-43. PMID: 18568113; PMCID: PMC2424120.
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THIOBARBITURATES.

Science (New York, N.Y.)

Miller E, Munch JC, Crossley FS.
PMID: 17733165
Science. 1935 Jun 21;81(2112):615. doi: 10.1126/science.81.2112.615.

No abstract available.

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Miller E, Munch JC, Crossley FS. THIOBARBITURATES. Science. 1935;81(2112):615doi: 10.1126/science.81.2112.615.
Miller, E., Munch, J. C., & Crossley, F. S. (1935). THIOBARBITURATES. Science (New York, N.Y.), 81(2112), 615. https://doi.org/10.1126/science.81.2112.615
Miller, E, et al. "THIOBARBITURATES." Science (New York, N.Y.) vol. 81,2112 (1935): 615. doi: https://doi.org/10.1126/science.81.2112.615
Miller E, Munch JC, Crossley FS. THIOBARBITURATES. Science. 1935 Jun 21;81(2112):615. doi: 10.1126/science.81.2112.615. PMID: 17733165.
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THIOBARBITURATES IN OBSTETRICS: PENTOTHAL AND THIOETHAMYL.

Canadian Medical Association journal

Bourne W, Pauly AJ.
PMID: 20321327
Can Med Assoc J. 1939 May;40(5):437-40.

No abstract available.

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Bourne W, Pauly AJ. THIOBARBITURATES IN OBSTETRICS: PENTOTHAL AND THIOETHAMYL. Can Med Assoc J. 1939;40(5):437-40
Bourne, W., & Pauly, A. J. (1939). THIOBARBITURATES IN OBSTETRICS: PENTOTHAL AND THIOETHAMYL. Canadian Medical Association journal, 40(5), 437-40.
Bourne, W, and Pauly, A J. "THIOBARBITURATES IN OBSTETRICS: PENTOTHAL AND THIOETHAMYL." Canadian Medical Association journal vol. 40,5 (1939): 437-40.
Bourne W, Pauly AJ. THIOBARBITURATES IN OBSTETRICS: PENTOTHAL AND THIOETHAMYL. Can Med Assoc J. 1939 May;40(5):437-40. PMID: 20321327; PMCID: PMC537157.
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Sustainable and scalable synthesis of polysubstituted bis-1,2,4-triazoles, bis-2-iminothiazolines and bis-thiobarbiturates using bis-.

Royal Society open science

Arafa WAA, Ibrahim HM.
PMID: 31312476
R Soc Open Sci. 2019 Jun 19;6(6):181963. doi: 10.1098/rsos.181963. eCollection 2019 Jun.

An expedient and tandem regioselective one-pot protocol for the sono-synthesis of bis-[1,2,4]-triazol-3-yl amines and bis-2-iminothiazolines from corresponding bis-1,3-disubstituted thioureas has been developed. The products' regioselectivity correlate well with the p

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Arafa WAA, Ibrahim HM. Sustainable and scalable synthesis of polysubstituted bis-1,2,4-triazoles, bis-2-iminothiazolines and bis-thiobarbiturates using bis-. R Soc Open Sci. 2019;6(6):181963doi: 10.1098/rsos.181963.
Arafa, W. A. A., & Ibrahim, H. M. (2019). Sustainable and scalable synthesis of polysubstituted bis-1,2,4-triazoles, bis-2-iminothiazolines and bis-thiobarbiturates using bis-. Royal Society open science, 6(6), 181963. https://doi.org/10.1098/rsos.181963
Arafa, Wael Abdelgayed Ahmed, and Ibrahim, Hamada Mohamed. "Sustainable and scalable synthesis of polysubstituted bis-1,2,4-triazoles, bis-2-iminothiazolines and bis-thiobarbiturates using bis-." Royal Society open science vol. 6,6 (2019): 181963. doi: https://doi.org/10.1098/rsos.181963
Arafa WAA, Ibrahim HM. Sustainable and scalable synthesis of polysubstituted bis-1,2,4-triazoles, bis-2-iminothiazolines and bis-thiobarbiturates using bis-. R Soc Open Sci. 2019 Jun 19;6(6):181963. doi: 10.1098/rsos.181963. eCollection 2019 Jun. PMID: 31312476; PMCID: PMC6599792.
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Showing 1 to 12 of 13 entries