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Pharmacokinetic properties and tolerability of single-dose terbutaline in patients with severe asthma treated in the pediatric intensive care unit.

Current therapeutic research, clinical and experimental

Lebovitz DJ, Smith PG, O'Riordan M, Reed MD.
PMID: 24936108
Curr Ther Res Clin Exp. 2004 Jan;65(1):98-109. doi: 10.1016/S0011-393X(04)90009-4.

BACKGROUND: Asthmatic children requiring treatment in the pediatric intensive care unit (PICU) receive aggressive drug therapy that may include IV administration of β 2-receptor agonists to prevent progression to life-threatening respiratory failure. The only pharmacologic agent in this class...

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Lebovitz DJ, Smith PG, O'Riordan M, et al. Pharmacokinetic properties and tolerability of single-dose terbutaline in patients with severe asthma treated in the pediatric intensive care unit. Curr Ther Res Clin Exp. 2004;65(1):98-109doi: 10.1016/S0011-393X(04)90009-4.
Lebovitz, D. J., Smith, P. G., O'Riordan, M., & Reed, M. D. (2004). Pharmacokinetic properties and tolerability of single-dose terbutaline in patients with severe asthma treated in the pediatric intensive care unit. Current therapeutic research, clinical and experimental, 65(1), 98-109. https://doi.org/10.1016/S0011-393X(04)90009-4
Lebovitz, Daniel J, et al. "Pharmacokinetic properties and tolerability of single-dose terbutaline in patients with severe asthma treated in the pediatric intensive care unit." Current therapeutic research, clinical and experimental vol. 65,1 (2004): 98-109. doi: https://doi.org/10.1016/S0011-393X(04)90009-4
Lebovitz DJ, Smith PG, O'Riordan M, Reed MD. Pharmacokinetic properties and tolerability of single-dose terbutaline in patients with severe asthma treated in the pediatric intensive care unit. Curr Ther Res Clin Exp. 2004 Jan;65(1):98-109. doi: 10.1016/S0011-393X(04)90009-4. PMID: 24936108; PMCID: PMC4052961.
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Palliative Subcutaneous Terbutaline Infusion in Severe Asthma.

Irish medical journal

Sahadevan A, Lane SJ.
PMID: 27685881
Ir Med J. 2016 May 10;109(5):410.

Continuous subcutaneous infusion of terbutaline (CSIT) has been shown to improve asthma control. As an adjunct to standard asthma pharmacotherapy, 3-12mg/day of CSIT can stabilise asthmatic symptoms, reduce hospitalisations and reduce corticosteroid need1,2. Asthmatics who demonstrate a wide diurnal...

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Sahadevan A, Lane SJ. Palliative Subcutaneous Terbutaline Infusion in Severe Asthma. Ir Med J. 2016;109(5):410
Sahadevan, A., & Lane, S. J. (2016). Palliative Subcutaneous Terbutaline Infusion in Severe Asthma. Irish medical journal, 109(5), 410.
Sahadevan, A, and Lane, S J. "Palliative Subcutaneous Terbutaline Infusion in Severe Asthma." Irish medical journal vol. 109,5 (2016): 410.
Sahadevan A, Lane SJ. Palliative Subcutaneous Terbutaline Infusion in Severe Asthma. Ir Med J. 2016 May 10;109(5):410. PMID: 27685881.
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Subcutaneous Terbutaline Pump for Maintenance of Tocolysis following Arrest of Acute Preterm Labor.

Obstetrics and gynecology international

Singh K, Ansari MT, Gaudet LM.
PMID: 24799909
Obstet Gynecol Int. 2014;2014:795329. doi: 10.1155/2014/795329. Epub 2014 Mar 31.

No abstract available.

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Singh K, Ansari MT, Gaudet LM. Subcutaneous Terbutaline Pump for Maintenance of Tocolysis following Arrest of Acute Preterm Labor. Obstet Gynecol Int. 2014;2014:795329doi: 10.1155/2014/795329.
Singh, K., Ansari, M. T., & Gaudet, L. M. (2014). Subcutaneous Terbutaline Pump for Maintenance of Tocolysis following Arrest of Acute Preterm Labor. Obstetrics and gynecology international, 2014795329. https://doi.org/10.1155/2014/795329
Singh, Kavita, et al. "Subcutaneous Terbutaline Pump for Maintenance of Tocolysis following Arrest of Acute Preterm Labor." Obstetrics and gynecology international vol. 2014 (2014): 795329. doi: https://doi.org/10.1155/2014/795329
Singh K, Ansari MT, Gaudet LM. Subcutaneous Terbutaline Pump for Maintenance of Tocolysis following Arrest of Acute Preterm Labor. Obstet Gynecol Int. 2014;2014:795329. doi: 10.1155/2014/795329. Epub 2014 Mar 31. PMID: 24799909; PMCID: PMC3988935.
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β2-AGONISTS IN CHILDHOOD ASTHMA.

Journal of biological regulators and homeostatic agents

Miraglia Del Giudice M, Campana G, Galdo F, De Vivo D, Cuppari C, Coronella A, Maiello N.
PMID: 26634602
J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):137-41.

β2-agonists reduce airflow limitation by improving airway diameter as a consequence of a direct action on airway smooth muscle. β;2-agonists can be broadly classified according to their duration of action: short-acting β2-agonists (SABAs), including albuterol, terbutaline and fenoterol, have...

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Miraglia Del Giudice M, Campana G, Galdo F, et al. β2-AGONISTS IN CHILDHOOD ASTHMA. J Biol Regul Homeost Agents. 2015;29(2):137-41
Miraglia Del Giudice, M., Campana, G., Galdo, F., De Vivo, D., Cuppari, C., Coronella, A., & Maiello, N. (2015). β2-AGONISTS IN CHILDHOOD ASTHMA. Journal of biological regulators and homeostatic agents, 29(2), 137-41.
Miraglia Del Giudice, M, et al. "β2-AGONISTS IN CHILDHOOD ASTHMA." Journal of biological regulators and homeostatic agents vol. 29,2 (2015): 137-41.
Miraglia Del Giudice M, Campana G, Galdo F, De Vivo D, Cuppari C, Coronella A, Maiello N. β2-AGONISTS IN CHILDHOOD ASTHMA. J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):137-41. PMID: 26634602.
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Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction.

Advanced drug delivery reviews

Shen DD, Kunze KL, Thummel KE.
PMID: 10837554
Adv Drug Deliv Rev. 1997 Sep 15;27(2):99-127. doi: 10.1016/s0169-409x(97)00039-2.

Oral bioavailability of pharmacologically effective drugs is often limited by first-pass biotransformation. In humans, both hepatic and intestinal enzymes can catalyze the metabolism of a drug as it transits between the gastrointestinal lumen and systemic blood for the first...

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Shen DD, Kunze KL, Thummel KE. Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction. Adv Drug Deliv Rev. 1997;27(2):99-127doi: 10.1016/s0169-409x(97)00039-2.
Shen, D. D., Kunze, K. L., & Thummel, K. E. (1997). Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction. Advanced drug delivery reviews, 27(2), 99-127. https://doi.org/10.1016/s0169-409x(97)00039-2
Shen, et al. "Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction." Advanced drug delivery reviews vol. 27,2 (1997): 99-127. doi: https://doi.org/10.1016/s0169-409x(97)00039-2
Shen DD, Kunze KL, Thummel KE. Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction. Adv Drug Deliv Rev. 1997 Sep 15;27(2):99-127. doi: 10.1016/s0169-409x(97)00039-2. PMID: 10837554.
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Preterm labor and maternal hypoxia in patients with community-acquired pneumonia.

Infectious diseases in obstetrics and gynecology

Maccato ML, Pinell P, Martens MG, Faro S.
PMID: 18476096
Infect Dis Obstet Gynecol. 1996;4(4):221-4. doi: 10.1155/S1064744996000427.

OBJECTIVE: We sought to determine if preterm labor is associated with the degree of maternal hypoxia in pregnant women with community-acquired pneumonia but no other maternal diseases.METHODS: We retrospectively reviewed the medical records of all antepartum patients admitted with...

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Maccato ML, Pinell P, Martens MG, et al. Preterm labor and maternal hypoxia in patients with community-acquired pneumonia. Infect Dis Obstet Gynecol. 1996;4(4):221-4doi: 10.1155/S1064744996000427.
Maccato, M. L., Pinell, P., Martens, M. G., & Faro, S. (1996). Preterm labor and maternal hypoxia in patients with community-acquired pneumonia. Infectious diseases in obstetrics and gynecology, 4(4), 221-4. https://doi.org/10.1155/S1064744996000427
Maccato, M L, et al. "Preterm labor and maternal hypoxia in patients with community-acquired pneumonia." Infectious diseases in obstetrics and gynecology vol. 4,4 (1996): 221-4. doi: https://doi.org/10.1155/S1064744996000427
Maccato ML, Pinell P, Martens MG, Faro S. Preterm labor and maternal hypoxia in patients with community-acquired pneumonia. Infect Dis Obstet Gynecol. 1996;4(4):221-4. doi: 10.1155/S1064744996000427. PMID: 18476096; PMCID: PMC2364494.
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Daily use of salmeterol causes tolerance to bronchodilation with terbutaline in asthmatic subjects.

The open respiratory medicine journal

Elers J, Strandbygaard U, Pedersen L, Backer V.
PMID: 20556208
Open Respir Med J. 2010 Apr 21;4:48-50. doi: 10.2174/1874306401004010048.

BACKGROUND: The purpose was to assess tolerance to terbutaline after daily use of long-acting beta2- agonist (LABA) and further to evaluate two designs of reversibility test widely used in research and clinic in order to demonstrate tolerance.METHODS: Twenty-eight asthmatics...

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Elers J, Strandbygaard U, Pedersen L, et al. Daily use of salmeterol causes tolerance to bronchodilation with terbutaline in asthmatic subjects. Open Respir Med J. 2010;4:48-50doi: 10.2174/1874306401004010048.
Elers, J., Strandbygaard, U., Pedersen, L., & Backer, V. (2010). Daily use of salmeterol causes tolerance to bronchodilation with terbutaline in asthmatic subjects. The open respiratory medicine journal, 448-50. https://doi.org/10.2174/1874306401004010048
Elers, Jimmi, et al. "Daily use of salmeterol causes tolerance to bronchodilation with terbutaline in asthmatic subjects." The open respiratory medicine journal vol. 4 (2010): 48-50. doi: https://doi.org/10.2174/1874306401004010048
Elers J, Strandbygaard U, Pedersen L, Backer V. Daily use of salmeterol causes tolerance to bronchodilation with terbutaline in asthmatic subjects. Open Respir Med J. 2010 Apr 21;4:48-50. doi: 10.2174/1874306401004010048. PMID: 20556208; PMCID: PMC2885602.
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Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin.

Indian journal of pharmaceutical sciences

Porel A, Haty S, Kundu A.
PMID: 22131621
Indian J Pharm Sci. 2011 Jan;73(1):46-56. doi: 10.4103/0250-474X.89756.

The aim of the present study was the development and subsequent validation of a simple, precise and stability-indicating reversed phase HPLC method for the simultaneous determination of guaifenesin, terbutaline sulphate and bromhexine hydrochloride in the presence of their potential...

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Porel A, Haty S, Kundu A. Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin. Indian J Pharm Sci. 2011;73(1):46-56doi: 10.4103/0250-474X.89756.
Porel, A., Haty, S., & Kundu, A. (2011). Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin. Indian journal of pharmaceutical sciences, 73(1), 46-56. https://doi.org/10.4103/0250-474X.89756
Porel, A, et al. "Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin." Indian journal of pharmaceutical sciences vol. 73,1 (2011): 46-56. doi: https://doi.org/10.4103/0250-474X.89756
Porel A, Haty S, Kundu A. Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin. Indian J Pharm Sci. 2011 Jan;73(1):46-56. doi: 10.4103/0250-474X.89756. PMID: 22131621; PMCID: PMC3224409.
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A validated HPTLC method for determination of terbutaline sulfate in biological samples: Application to pharmacokinetic study.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Faiyazuddin M, Rauf A, Ahmad N, Ahmad S, Iqbal Z, Talegaonkar S, Bhatnagar A, Khar RK, Ahmad FJ.
PMID: 23960758
Saudi Pharm J. 2011 Jul;19(3):185-91. doi: 10.1016/j.jsps.2011.03.004. Epub 2011 Apr 01.

Terbutaline sulfate (TBS) was assayed in biological samples by validated HPTLC method. Densitometric analysis of TBS was carried out at 366 nm on precoated TLC aluminum plates with silica gel 60F254 as a stationary phase and chloroform-methanol (9.0:1.0, v/v)...

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Faiyazuddin M, Rauf A, Ahmad N, et al. A validated HPTLC method for determination of terbutaline sulfate in biological samples: Application to pharmacokinetic study. Saudi Pharm J. 2011;19(3):185-91doi: 10.1016/j.jsps.2011.03.004.
Faiyazuddin, M., Rauf, A., Ahmad, N., Ahmad, S., Iqbal, Z., Talegaonkar, S., Bhatnagar, A., Khar, R. K., & Ahmad, F. J. (2011). A validated HPTLC method for determination of terbutaline sulfate in biological samples: Application to pharmacokinetic study. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 19(3), 185-91. https://doi.org/10.1016/j.jsps.2011.03.004
Faiyazuddin, Md, et al. "A validated HPTLC method for determination of terbutaline sulfate in biological samples: Application to pharmacokinetic study." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 19,3 (2011): 185-91. doi: https://doi.org/10.1016/j.jsps.2011.03.004
Faiyazuddin M, Rauf A, Ahmad N, Ahmad S, Iqbal Z, Talegaonkar S, Bhatnagar A, Khar RK, Ahmad FJ. A validated HPTLC method for determination of terbutaline sulfate in biological samples: Application to pharmacokinetic study. Saudi Pharm J. 2011 Jul;19(3):185-91. doi: 10.1016/j.jsps.2011.03.004. Epub 2011 Apr 01. PMID: 23960758; PMCID: PMC3745045.
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Capillary Leak Syndrome Following Snakebite Envenomation.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Udayabhaskaran V, Arun Thomas ET, Shaji B.
PMID: 29142382
Indian J Crit Care Med. 2017 Oct;21(10):698-702. doi: 10.4103/ijccm.IJCCM_41_17.

Capillary leak syndrome is a unique complication that follows Russell's viper envenomation. This syndrome has a very high fatality rate and is characterized by parotid swelling, chemosis, periorbital edema, hypotension, albuminuria, hypoalbuminemia, and hemoconcentration. This syndrome is frequently recognized...

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Udayabhaskaran V, Arun Thomas ET, Shaji B. Capillary Leak Syndrome Following Snakebite Envenomation. Indian J Crit Care Med. 2017;21(10):698-702doi: 10.4103/ijccm.IJCCM_41_17.
Udayabhaskaran, V., Arun Thomas, E. T., & Shaji, B. (2017). Capillary Leak Syndrome Following Snakebite Envenomation. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 21(10), 698-702. https://doi.org/10.4103/ijccm.IJCCM_41_17
Udayabhaskaran, V, et al. "Capillary Leak Syndrome Following Snakebite Envenomation." Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine vol. 21,10 (2017): 698-702. doi: https://doi.org/10.4103/ijccm.IJCCM_41_17
Udayabhaskaran V, Arun Thomas ET, Shaji B. Capillary Leak Syndrome Following Snakebite Envenomation. Indian J Crit Care Med. 2017 Oct;21(10):698-702. doi: 10.4103/ijccm.IJCCM_41_17. PMID: 29142382; PMCID: PMC5672676.
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β₂-Adrenoceptor Blockade Deteriorates Systemic Anaphylaxis by Enhancing Hyperpermeability in Anesthetized Mice.

Allergy, asthma & immunology research

Yang W, Shibamoto T, Kuda Y, Zhang T, Tanida M, Kurata Y.
PMID: 29178678
Allergy Asthma Immunol Res. 2018 Jan;10(1):52-61. doi: 10.4168/aair.2018.10.1.52.

PURPOSE: Patients treated with propranolol, a nonselective β-adrenoceptor antagonist, develop severe anaphylaxis, but the mechanism remains unknown. We determined effects of β₁- and β₂-adrenoceptor antagonists on the anaphylaxis-induced increase in vascular permeability in mice.METHODS: In anesthetized ovalbumin-sensitized C57BL mice,...

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Yang W, Shibamoto T, Kuda Y, et al. β₂-Adrenoceptor Blockade Deteriorates Systemic Anaphylaxis by Enhancing Hyperpermeability in Anesthetized Mice. Allergy Asthma Immunol Res. 2018;10(1):52-61doi: 10.4168/aair.2018.10.1.52.
Yang, W., Shibamoto, T., Kuda, Y., Zhang, T., Tanida, M., & Kurata, Y. (2018). β₂-Adrenoceptor Blockade Deteriorates Systemic Anaphylaxis by Enhancing Hyperpermeability in Anesthetized Mice. Allergy, asthma & immunology research, 10(1), 52-61. https://doi.org/10.4168/aair.2018.10.1.52
Yang, Wei, et al. "β₂-Adrenoceptor Blockade Deteriorates Systemic Anaphylaxis by Enhancing Hyperpermeability in Anesthetized Mice." Allergy, asthma & immunology research vol. 10,1 (2018): 52-61. doi: https://doi.org/10.4168/aair.2018.10.1.52
Yang W, Shibamoto T, Kuda Y, Zhang T, Tanida M, Kurata Y. β₂-Adrenoceptor Blockade Deteriorates Systemic Anaphylaxis by Enhancing Hyperpermeability in Anesthetized Mice. Allergy Asthma Immunol Res. 2018 Jan;10(1):52-61. doi: 10.4168/aair.2018.10.1.52. PMID: 29178678; PMCID: PMC5705484.
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Subcutaneous terbutaline as an alternative to metered-dose inhalers for asthma during the COVID-19 pandemic.

Journal of the American College of Emergency Physicians open

Strauss RA.
PMID: 32838384
J Am Coll Emerg Physicians Open. 2020 Jul 02; doi: 10.1002/emp2.12131. Epub 2020 Jul 02.

No abstract available.

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Strauss RA. Subcutaneous terbutaline as an alternative to metered-dose inhalers for asthma during the COVID-19 pandemic. J Am Coll Emerg Physicians Open. 2020;doi: 10.1002/emp2.12131.
Strauss, R. A. (2020). Subcutaneous terbutaline as an alternative to metered-dose inhalers for asthma during the COVID-19 pandemic. Journal of the American College of Emergency Physicians open, . https://doi.org/10.1002/emp2.12131
Strauss, Ronald A. "Subcutaneous terbutaline as an alternative to metered-dose inhalers for asthma during the COVID-19 pandemic." Journal of the American College of Emergency Physicians open vol. (2020). doi: https://doi.org/10.1002/emp2.12131
Strauss RA. Subcutaneous terbutaline as an alternative to metered-dose inhalers for asthma during the COVID-19 pandemic. J Am Coll Emerg Physicians Open. 2020 Jul 02; doi: 10.1002/emp2.12131. Epub 2020 Jul 02. PMID: 32838384; PMCID: PMC7361363.
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