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Showing 1 to 12 of 6694 entries
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Mechanisms for synchronized burst firing in pyramidal cells using oscillatory inhibition: a model for attentional control

pedagogy

Tiesinga PHE.
GSID: JWbvN17qP-sJ
C Fischer, PHE Tiesinga, M Wal - BMC …, 2015 - bmcneurosci.biomedcentral.com

Pyramidal cells have two different action potential initiation sites; one at the soma, which receives inputs from synapses contacting the basal dendrites or the soma, and one at the …

Strength through diversity

diversity

Nelson SB, Turrigiano GG.
GSID: W8tlTnPpPpQJ
SB Nelson, GG Turrigiano - Neuron, 2008 - Elsevier

The remarkable versatility of the mammalian brain is made possible by a huge diversity of cellular plasticity mechanisms. These include long-term potentiation and depression at both excitatory and inhibitory synapses, as well as a variety of intrinsic and homeostatic...

CIRCUIT summer program: A computational neuroscience outreach experience for high-achieving undergraduates via sponsored research

Broadening Participation in Computing AND Program Evaluation

Downs J.
GSID: 1g6RHGCdQFcJ
M Encarnacion, C Bishop, J Downs… - 2018 IEEE …, 2018 - ieeexplore.ieee.org

Programs that focus on student outreach are often disjoint from sponsored research efforts, despite the mutually beneficial opportunities that are possible with a combined approach. We designed and piloted a program to simultaneously meet the needs of underserved students...

Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome

STEM and girls

Medrihan L.
GSID: cEB9GcdZXzIJ
L Medrihan, E Tantalaki, G Aramuni… - Journal of …, 2008 - journals.physiology.org

… the leading genetic cause for mental retardation in girls. MeCP2-mutant mice have been generated … pathways are impaired in the brain stem during early postnatal development. These …

The role of dendritic inhibition in shaping the plasticity of excitatory synapses.

Frontiers in neural circuits

Bar-Ilan L, Gidon A, Segev I.
PMID: 23565076
Front Neural Circuits. 2013 Apr 03;6:118. doi: 10.3389/fncir.2012.00118. eCollection 2012.

Using computational tools we explored the impact of local synaptic inhibition on the plasticity of excitatory synapses in dendrites. The latter critically depends on the intracellular concentration of calcium, which in turn, depends on membrane potential and thus on...

Mephedrone alters basal ganglia and limbic dynorphin systems.

Synapse (New York, N.Y.)

German CL, Alburges ME, Hoonakker AJ, Fleckenstein AE, Hanson GR.
PMID: 25155699
Synapse. 2014 Dec;68(12):634-640. doi: 10.1002/syn.21778. Epub 2014 Sep 08.

Mephedrone (4-methymethcathinone) is a synthetic cathinone designer drug that disrupts central nervous system (CNS) dopamine (DA) signaling. Numerous central neuropeptide systems reciprocally interact with dopaminergic neurons to provide regulatory counterbalance, and are altered by aberrant DA activity associated with...

Analysis of shape and spatial interaction of synaptic vesicles using data from focused ion beam scanning electron microscopy (FIB-SEM).

Frontiers in neuroanatomy

Khanmohammadi M, Waagepetersen RP, Sporring J.
PMID: 26388743
Front Neuroanat. 2015 Sep 01;9:116. doi: 10.3389/fnana.2015.00116. eCollection 2015.

The spatial interactions of synaptic vesicles in synapses were assessed after a detailed characterization of size, shape, and orientation of the synaptic vesicles. We hypothesized that shape and orientation of the synaptic vesicles are influenced by their movement toward...

Corrigendum: Spiking Neural Networks Based on OxRAM Synapses for Real-Time Unsupervised Spike Sorting.

Frontiers in neuroscience

Werner T, Vianello E, Bichler O, Garbin D, Cattaert D, Yvert B, De Salvo B, Perniola L.
PMID: 28878617
Front Neurosci. 2017 Aug 29;11:486. doi: 10.3389/fnins.2017.00486. eCollection 2017.

[This corrects the article on p. 474 in vol. 10, PMID: 27857680.].

Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function.

Frontiers in neurology

Curthoys IS, MacDougall HG, Vidal PP, de Waele C.
PMID: 28424655
Front Neurol. 2017 Mar 30;8:117. doi: 10.3389/fneur.2017.00117. eCollection 2017.

Otolithic afferents with regular resting discharge respond to gravity or low-frequency linear accelerations, and we term these the static or sustained otolithic system. However, in the otolithic sense organs, there is anatomical differentiation across the maculae and corresponding physiological...

Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior.

Pharmacological reviews

Crews FT, Vetreno RP, Broadwater MA, Robinson DL.
PMID: 27677720
Pharmacol Rev. 2016 Oct;68(4):1074-1109. doi: 10.1124/pr.115.012138.

Adolescence is a developmental period when physical and cognitive abilities are optimized, when social skills are consolidated, and when sexuality, adolescent behaviors, and frontal cortical functions mature to adult levels. Adolescents also have unique responses to alcohol compared with...

Crossbar Nanoscale HfO2-Based Electronic Synapses.

Nanoscale research letters

Matveyev Y, Kirtaev R, Fetisova A, Zakharchenko S, Negrov D, Zenkevich A.
PMID: 26979725
Nanoscale Res Lett. 2016 Dec;11(1):147. doi: 10.1186/s11671-016-1360-6. Epub 2016 Mar 15.

Crossbar resistive switching devices down to 40 × 40 nm(2) in size comprising 3-nm-thick HfO2 layers are forming-free and exhibit up to 10(5) switching cycles. Four-nanometer-thick devices display the ability of gradual switching in both directions, thus emulating long-term...

Acetone promoted 1,4-migration of an alkoxycarbonyl group on a syn-1,2-diamine.

Tetrahedron letters

Napolitano T, Cheng SY, Nielsen B, Choi C, Aguilar W, Paz MM, Sapse AM, Champeil E.
PMID: 28943668
Tetrahedron Lett. 2017 Feb 15;58(7):597-601. doi: 10.1016/j.tetlet.2016.12.047. Epub 2017 Jan 03.

A 2-protected cis-amino mitosene undergoes an irreversible acetone promoted isomerization and converts to the 1-isomer. Kinetic studies and DFT calculations of the reaction are reported. An organocatalytic mechanism is proposed, involving a covalent intermediate formed by reaction of the...

Showing 1 to 12 of 6694 entries