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Pharmacological Interventions in Aging and Age‐associated Disorders: Potentials of Propargylamines for Human Use

Stem education interventions

[No authors listed]
GSID: 1Ey0q7sFmnUJ
K Kitani, C Minami, T Yamamoto… - Annals of the New …, 2002 - Wiley Online Library

Past studies including our own have confirmed that chronic administration of deprenyl can prolong life spans of at least four different animal species. Pretreatment with the drug for several weeks increases activities of superoxide dismutase (SOD) and catalase (CAT)...

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Kitani, K., Minami, C., Yamamoto, T., Kanai, S., Ivy, G. O., & CARRILLO, M. C. (2002). Pharmacological Interventions in Aging and Age‐associated Disorders: Potentials of Propargylamines for Human Use. Annals of the New York Academy of Sciences, 959(1), 295-307.
Kitani, Kenichi, et al. "Pharmacological Interventions in Aging and Age‐associated Disorders: Potentials of Propargylamines for Human Use." Annals of the New York Academy of Sciences 959.1 (2002): 295-307.
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The role of oxidative stress in menopause.

Journal of mid-life health

Doshi SB, Agarwal A.
PMID: 24672185
J Midlife Health. 2013 Jul;4(3):140-6. doi: 10.4103/0976-7800.118990.

This review will discuss the concept of reproductive aging, which includes the definition of menopause, its symptoms, and predisposing conditions. It will elaborate upon the contributory factors implicated in the pathogenesis of menopause, focusing most prominently on oxidative stress....

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Doshi SB, Agarwal A. The role of oxidative stress in menopause. J Midlife Health. 2013;4(3):140-6doi: 10.4103/0976-7800.118990.
Doshi, S. B., & Agarwal, A. (2013). The role of oxidative stress in menopause. Journal of mid-life health, 4(3), 140-6. https://doi.org/10.4103/0976-7800.118990
Doshi, Sejal B, and Agarwal, Ashok. "The role of oxidative stress in menopause." Journal of mid-life health vol. 4,3 (2013): 140-6. doi: https://doi.org/10.4103/0976-7800.118990
Doshi SB, Agarwal A. The role of oxidative stress in menopause. J Midlife Health. 2013 Jul;4(3):140-6. doi: 10.4103/0976-7800.118990. PMID: 24672185; PMCID: PMC3952404.
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Pioglitazone Inhibits the Expressions of p22(phox) and p47(phox) in Rat Mesangial Cells In Vitro.

ISRN endocrinology

Wang S, Ye SD, Sun WJ, Hu YY.
PMID: 24639901
ISRN Endocrinol. 2014 Feb 03;2014:601352. doi: 10.1155/2014/601352. eCollection 2014.

Aim. The purpose of this study was to investigate the effects of pioglitazone on oxidative stress and the expressions of p22(phox) and p47(phox), subunits of NADPH oxidase, in mesangial cells (MCs). Method. Rat mesangial cells were cultured and randomly...

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Wang S, Ye SD, Sun WJ, et al. Pioglitazone Inhibits the Expressions of p22(phox) and p47(phox) in Rat Mesangial Cells In Vitro. ISRN Endocrinol. 2014;2014:601352doi: 10.1155/2014/601352.
Wang, S., Ye, S. D., Sun, W. J., & Hu, Y. Y. (2014). Pioglitazone Inhibits the Expressions of p22(phox) and p47(phox) in Rat Mesangial Cells In Vitro. ISRN endocrinology, 2014601352. https://doi.org/10.1155/2014/601352
Wang, Shan, et al. "Pioglitazone Inhibits the Expressions of p22(phox) and p47(phox) in Rat Mesangial Cells In Vitro." ISRN endocrinology vol. 2014 (2014): 601352. doi: https://doi.org/10.1155/2014/601352
Wang S, Ye SD, Sun WJ, Hu YY. Pioglitazone Inhibits the Expressions of p22(phox) and p47(phox) in Rat Mesangial Cells In Vitro. ISRN Endocrinol. 2014 Feb 03;2014:601352. doi: 10.1155/2014/601352. eCollection 2014. PMID: 24639901; PMCID: PMC3929998.
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The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis.

Frontiers in aging neuroscience

Lovejoy DB, Guillemin GJ.
PMID: 25100994
Front Aging Neurosci. 2014 Jul 23;6:173. doi: 10.3389/fnagi.2014.00173. eCollection 2014.

Modulations of the potentially toxic transition metals iron (Fe) and copper (Cu) are implicated in the neurodegenerative process in a variety of human disease states including amyotrophic lateral sclerosis (ALS). However, the precise role played by these metals is...

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Lovejoy DB, Guillemin GJ. The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis. Front Aging Neurosci. 2014;6:173doi: 10.3389/fnagi.2014.00173.
Lovejoy, D. B., & Guillemin, G. J. (2014). The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis. Frontiers in aging neuroscience, 6173. https://doi.org/10.3389/fnagi.2014.00173
Lovejoy, David B, and Guillemin, Gilles J. "The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis." Frontiers in aging neuroscience vol. 6 (2014): 173. doi: https://doi.org/10.3389/fnagi.2014.00173
Lovejoy DB, Guillemin GJ. The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis. Front Aging Neurosci. 2014 Jul 23;6:173. doi: 10.3389/fnagi.2014.00173. eCollection 2014. PMID: 25100994; PMCID: PMC4107949.
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Ameliorative effect of ocimum sanctum on meloxicam induced toxicity in wistar rats.

Toxicology international

Mahaprabhu R, Bhandarkar AG, Jangir BL, Rahangadale SP, Kurkure NV.
PMID: 21976818
Toxicol Int. 2011 Jul;18(2):130-6. doi: 10.4103/0971-6580.84265.

An ameliorating effect of Ocimum sanctum on the toxic effect of meloxicam, a new non-steroidal anti-inflammatory drug was studied by evaluating haemato-biochemical parameters, oxidative stress, gross and histopathological changes in various organs of Wistar rats. A total of thirty-six...

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Mahaprabhu R, Bhandarkar AG, Jangir BL, et al. Ameliorative effect of ocimum sanctum on meloxicam induced toxicity in wistar rats. Toxicol Int. 2011;18(2):130-6doi: 10.4103/0971-6580.84265.
Mahaprabhu, R., Bhandarkar, A. G., Jangir, B. L., Rahangadale, S. P., & Kurkure, N. V. (2011). Ameliorative effect of ocimum sanctum on meloxicam induced toxicity in wistar rats. Toxicology international, 18(2), 130-6. https://doi.org/10.4103/0971-6580.84265
Mahaprabhu, R, et al. "Ameliorative effect of ocimum sanctum on meloxicam induced toxicity in wistar rats." Toxicology international vol. 18,2 (2011): 130-6. doi: https://doi.org/10.4103/0971-6580.84265
Mahaprabhu R, Bhandarkar AG, Jangir BL, Rahangadale SP, Kurkure NV. Ameliorative effect of ocimum sanctum on meloxicam induced toxicity in wistar rats. Toxicol Int. 2011 Jul;18(2):130-6. doi: 10.4103/0971-6580.84265. PMID: 21976818; PMCID: PMC3183620.
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BNC Protects H9c2 Cardiomyoblasts from H 2 O 2 -Induced Oxidative Injury through ERK1/2 Signaling Pathway.

Evidence-based complementary and alternative medicine : eCAM

Zhang F, Huang B, Zhao Y, Tang S, Xu H, Wang L, Liang R, Yang H.
PMID: 24223618
Evid Based Complement Alternat Med. 2013;2013:802784. doi: 10.1155/2013/802784. Epub 2013 Oct 10.

Buchang naoxintong capsule (BNC) is a traditional Chinese medicine approved for the treatment of cerebrovascular and cardiovascular diseases. However, little is known about the specific protective function or mechanism by which BNC protects against myocardial injury. This research was...

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Zhang F, Huang B, Zhao Y, et al. BNC Protects H9c2 Cardiomyoblasts from H 2 O 2 -Induced Oxidative Injury through ERK1/2 Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:802784doi: 10.1155/2013/802784.
Zhang, F., Huang, B., Zhao, Y., Tang, S., Xu, H., Wang, L., Liang, R., & Yang, H. (2013). BNC Protects H9c2 Cardiomyoblasts from H 2 O 2 -Induced Oxidative Injury through ERK1/2 Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM, 2013802784. https://doi.org/10.1155/2013/802784
Zhang, Fangbo, et al. "BNC Protects H9c2 Cardiomyoblasts from H 2 O 2 -Induced Oxidative Injury through ERK1/2 Signaling Pathway." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 802784. doi: https://doi.org/10.1155/2013/802784
Zhang F, Huang B, Zhao Y, Tang S, Xu H, Wang L, Liang R, Yang H. BNC Protects H9c2 Cardiomyoblasts from H 2 O 2 -Induced Oxidative Injury through ERK1/2 Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:802784. doi: 10.1155/2013/802784. Epub 2013 Oct 10. PMID: 24223618; PMCID: PMC3810482.
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Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract.

Journal of ginseng research

Sharma J, Goyal PK.
PMID: 26199559
J Ginseng Res. 2015 Jul;39(3):265-73. doi: 10.1016/j.jgr.2015.01.005. Epub 2015 Feb 07.

BACKGROUND: Cancer has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing cancer burden. Recently, some...

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Sharma J, Goyal PK. Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract. J Ginseng Res. 2015;39(3):265-73doi: 10.1016/j.jgr.2015.01.005.
Sharma, J., & Goyal, P. K. (2015). Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract. Journal of ginseng research, 39(3), 265-73. https://doi.org/10.1016/j.jgr.2015.01.005
Sharma, Jyoti, and Goyal, Pradeep K. "Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract." Journal of ginseng research vol. 39,3 (2015): 265-73. doi: https://doi.org/10.1016/j.jgr.2015.01.005
Sharma J, Goyal PK. Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract. J Ginseng Res. 2015 Jul;39(3):265-73. doi: 10.1016/j.jgr.2015.01.005. Epub 2015 Feb 07. PMID: 26199559; PMCID: PMC4506367.
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Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria.

Iranian journal of pharmaceutical research : IJPR

Rezaiean Mehrabadi A, Jamshidzadeh A, Rashedinia M, Niknahad H.
PMID: 26330870
Iran J Pharm Res. 2015;14(3):825-32.

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of...

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Rezaiean Mehrabadi A, Jamshidzadeh A, Rashedinia M, et al. Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria. Iran J Pharm Res. 2015;14(3):825-32
Rezaiean Mehrabadi, A., Jamshidzadeh, A., Rashedinia, M., & Niknahad, H. (2015). Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria. Iranian journal of pharmaceutical research : IJPR, 14(3), 825-32.
Rezaiean Mehrabadi, Abbas, et al. "Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria." Iranian journal of pharmaceutical research : IJPR vol. 14,3 (2015): 825-32.
Rezaiean Mehrabadi A, Jamshidzadeh A, Rashedinia M, Niknahad H. Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria. Iran J Pharm Res. 2015;14(3):825-32. PMID: 26330870; PMCID: PMC4518110.
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Drosophila melanogaster - an embryonic model for studying behavioral and biochemical effects of manganese exposure.

EXCLI journal

Ternes AP, Zemolin AP, da Cruz LC, da Silva GF, Saidelles AP, de Paula MT, Wagner C, Golombieski RM, Flores ÉM, Picoloto RS, Pereira AB, Franco JL, Posser T.
PMID: 26417337
EXCLI J. 2014 Nov 21;13:1239-53. eCollection 2014.

Embryonic animals are especially susceptible to metal exposure. Manganese (Mn) is an essential element, but in excess it can induce toxicity. In this study we used Drosophila melanogaster as an embryonic model to investigate biochemical and behavioral alterations due...

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Ternes AP, Zemolin AP, da Cruz LC, et al. Drosophila melanogaster - an embryonic model for studying behavioral and biochemical effects of manganese exposure. EXCLI J. 2014;13:1239-53
Ternes, A. P., Zemolin, A. P., da Cruz, L. C., da Silva, G. F., Saidelles, A. P., de Paula, M. T., Wagner, C., Golombieski, R. M., Flores, �. �. M., Picoloto, R. S., Pereira, A. B., Franco, J. L., & Posser, T. (2014). Drosophila melanogaster - an embryonic model for studying behavioral and biochemical effects of manganese exposure. EXCLI journal, 131239-53.
Ternes, Ana Paula Lausmann, et al. "Drosophila melanogaster - an embryonic model for studying behavioral and biochemical effects of manganese exposure." EXCLI journal vol. 13 (2014): 1239-53.
Ternes AP, Zemolin AP, da Cruz LC, da Silva GF, Saidelles AP, de Paula MT, Wagner C, Golombieski RM, Flores ÉM, Picoloto RS, Pereira AB, Franco JL, Posser T. Drosophila melanogaster - an embryonic model for studying behavioral and biochemical effects of manganese exposure. EXCLI J. 2014 Nov 21;13:1239-53. eCollection 2014. PMID: 26417337; PMCID: PMC4464430.
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Suppression of Magnaporthe oryzae and interaction between Bacillus subtilis and rice plants in the control of rice blast.

SpringerPlus

Sha Y, Wang Q, Li Y.
PMID: 27536521
Springerplus. 2016 Aug 02;5(1):1238. doi: 10.1186/s40064-016-2858-1. eCollection 2016.

Magnaporthe oryzae, the causative pathogen of rice blast, has caused extensive losses to rice cultivation worldwide. Strains of the bacterium Bacillus subtilis have been used as biocontrol agents against rice blast. However, little has been reported about the interaction...

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Sha Y, Wang Q, Li Y. Suppression of Magnaporthe oryzae and interaction between Bacillus subtilis and rice plants in the control of rice blast. Springerplus. 2016;5(1):1238doi: 10.1186/s40064-016-2858-1.
Sha, Y., Wang, Q., & Li, Y. (2016). Suppression of Magnaporthe oryzae and interaction between Bacillus subtilis and rice plants in the control of rice blast. SpringerPlus, 5(1), 1238. https://doi.org/10.1186/s40064-016-2858-1
Sha, Yuexia, et al. "Suppression of Magnaporthe oryzae and interaction between Bacillus subtilis and rice plants in the control of rice blast." SpringerPlus vol. 5,1 (2016): 1238. doi: https://doi.org/10.1186/s40064-016-2858-1
Sha Y, Wang Q, Li Y. Suppression of Magnaporthe oryzae and interaction between Bacillus subtilis and rice plants in the control of rice blast. Springerplus. 2016 Aug 02;5(1):1238. doi: 10.1186/s40064-016-2858-1. eCollection 2016. PMID: 27536521; PMCID: PMC4971003.
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Effect of BDNF and Other Potential Survival Factors in Models of In Vitro Oxidative Stress on Adult Spinal Cord-Derived Neural Stem/Progenitor Cells.

BioResearch open access

Hachem LD, Mothe AJ, Tator CH.
PMID: 26309791
Biores Open Access. 2015 Feb 01;4(1):146-59. doi: 10.1089/biores.2014.0058. eCollection 2015.

Transplantation of neural stem/progenitor cells (NSPCs) is a promising strategy in spinal cord injury (SCI). However, poor survival of transplanted stem cells remains a major limitation of this therapy due to the hostile environment of the injured cord. Oxidative...

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Hachem LD, Mothe AJ, Tator CH. Effect of BDNF and Other Potential Survival Factors in Models of In Vitro Oxidative Stress on Adult Spinal Cord-Derived Neural Stem/Progenitor Cells. Biores Open Access. 2015;4(1):146-59doi: 10.1089/biores.2014.0058.
Hachem, L. D., Mothe, A. J., & Tator, C. H. (2015). Effect of BDNF and Other Potential Survival Factors in Models of In Vitro Oxidative Stress on Adult Spinal Cord-Derived Neural Stem/Progenitor Cells. BioResearch open access, 4(1), 146-59. https://doi.org/10.1089/biores.2014.0058
Hachem, Laureen D, et al. "Effect of BDNF and Other Potential Survival Factors in Models of In Vitro Oxidative Stress on Adult Spinal Cord-Derived Neural Stem/Progenitor Cells." BioResearch open access vol. 4,1 (2015): 146-59. doi: https://doi.org/10.1089/biores.2014.0058
Hachem LD, Mothe AJ, Tator CH. Effect of BDNF and Other Potential Survival Factors in Models of In Vitro Oxidative Stress on Adult Spinal Cord-Derived Neural Stem/Progenitor Cells. Biores Open Access. 2015 Feb 01;4(1):146-59. doi: 10.1089/biores.2014.0058. eCollection 2015. PMID: 26309791; PMCID: PMC4497651.
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Calcitriol promotes survival of experimental random pattern flap via activation of autophagy.

American journal of translational research

Chen L, Zhou K, Chen H, Li S, Lin D, Zhou D.
PMID: 28861155
Am J Transl Res. 2017 Aug 15;9(8):3642-3653. eCollection 2017.

Calcitriol can promote random pattern flap survival and increase autophagy activity. However, effect of autophagy on flap survival after calcitriol treatment, along with the underlying mechanism, is undefined. In this study, the "McFarlane flap" model was established in 72...

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Chen L, Zhou K, Chen H, et al. Calcitriol promotes survival of experimental random pattern flap via activation of autophagy. Am J Transl Res. 2017;9(8):3642-3653
Chen, L., Zhou, K., Chen, H., Li, S., Lin, D., & Zhou, D. (2017). Calcitriol promotes survival of experimental random pattern flap via activation of autophagy. American journal of translational research, 9(8), 3642-3653.
Chen, Long, et al. "Calcitriol promotes survival of experimental random pattern flap via activation of autophagy." American journal of translational research vol. 9,8 (2017): 3642-3653.
Chen L, Zhou K, Chen H, Li S, Lin D, Zhou D. Calcitriol promotes survival of experimental random pattern flap via activation of autophagy. Am J Transl Res. 2017 Aug 15;9(8):3642-3653. eCollection 2017. PMID: 28861155; PMCID: PMC5575178.
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Showing 1 to 12 of 7672 entries