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Subcellular and molecular mechanisms of bile secretion.

International review of cytology

Burwen SJ, Schmucker DL, Jones AL.
PMID: 1618608
Int Rev Cytol. 1992;135:269-313. doi: 10.1016/s0074-7696(08)62043-4.

One of the liver's principal functions is the formation of bile, which is requisite for digestion of fat and elimination of detoxified drugs and metabolites. Bile is a complex fluid made up of water, electrolytes, bile acids, pigments, proteins,...

Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats.

The Journal of biological chemistry

Fernández-Checa JC, Takikawa H, Horie T, Ookhtens M, Kaplowitz N.
PMID: 1730711
J Biol Chem. 1992 Jan 25;267(3):1667-73.
Free Article

We have characterized the transport of GSH and the mechanism for impaired GSH transport in mutant Eisai hyperbilirubinemic rats (EHBR) using isolated canalicular membrane-enriched vesicles (cLPM). In control animals, the transport of GSH is an electrogenic process and is...

Age-related alterations of enzyme activities and subunits of hepatic glutathione S-transferases in male and female Fischer-344 rats.

Biochimica et biophysica acta

Carrillo MC, Nokubo M, Kitani K, Satoh K, Sato K.
PMID: 2029531
Biochim Biophys Acta. 1991 Apr 29;1077(3):325-31. doi: 10.1016/0167-4838(91)90547-d.

Enzyme activities of glutathione S-transferases (GSTs) toward five different substrates (benzalacetone (PBO), styrene oxide (STOX), sulfobromophthalein (BSP), 1,2-dichloro-4-nitrobenzene (DCNB) and 1-chloro-2,4-dinitrobenzene (CDNB)) as well as concentrations of four subunits of GST isozymes (1, 2, 3 and 4) were determined...

Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters.

Toxicology and applied pharmacology

Runnegar M, Berndt N, Kaplowitz N.
PMID: 7570603
Toxicol Appl Pharmacol. 1995 Oct;134(2):264-72. doi: 10.1006/taap.1995.1192.

The microcystins (Mcyst) are cyclic peptide hepatotoxins produced by cyanobacteria. They are chemically very stable and represent a public health threat when they occur in water bodies used for human consumption. Mice injected ip with Mcyst (LD50 50-100 micrograms/kg)...

Distribution of rat organic anion transporting polypeptide-E (oatp-E) in the rat eye.

Investigative ophthalmology & visual science

Ito A, Yamaguchi K, Tomita H, Suzuki T, Onogawa T, Sato T, Mizutamari H, Mikkaichi T, Nishio T, Suzuki T, Unno M, Sasano H, Abe T, Tamai M.
PMID: 14578412
Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4877-84. doi: 10.1167/iovs.02-1108.

PURPOSE: To examine the protein and mRNA expression levels of the recently cloned rat multifunctional Na+-independent organic anion transporting polypeptide (rat oatp-E), which is involved in the transport of thyroid hormone in the rat, the distribution and function of...

The effect of cholecystokinin-octapeptide on the hepatobiliary dysfunction caused by total parenteral nutrition.

Journal of pediatric surgery

Curran TJ, Uzoaru I, Das JB, Ansari G, Raffensperger JG.
PMID: 7738745
J Pediatr Surg. 1995 Feb;30(2):242-6; discussion 246-7. doi: 10.1016/0022-3468(95)90568-5.

PURPOSE: Patients on total parenteral nutrition (TPN) commonly have hepatobiliary dysfunction. Interruption of the enterohepatic circulation (EHC) and gallbladder stasis are part of the pathogenesis. Cholecystokinin-octapeptide (CCK-OP), by emptying the gallbladder, stimulates the EHC. This study was performed to...

An endogenous ATP-sensitive glutathione S-conjugate efflux mechanism in Xenopus laevis oocytes.

The American journal of physiology

Ballatori N, Wang W, Li L, Truong AT.
PMID: 8928920
Am J Physiol. 1996 May;270(5):R1156-62. doi: 10.1152/ajpregu.1996.270.5.R1156.

Constitutive efflux mechanisms for reduced glutathione (GSH) and the glutathione S-conjugates S-ethylglutathione (ethyl-SG) and S-(2,4-dinitrophenol)-glutathione (DNP-SG) were examined in Xenopus laevis oocytes. Oocytes were loaded by either microinjection with 50 nl of the 3H-labeled compounds or were exposed to...

Identification and characterization of high and low affinity transport systems for reduced glutathione in liver cell canalicular membranes.

The Journal of biological chemistry

Ballatori N, Dutczak WJ.
PMID: 8051053
J Biol Chem. 1994 Aug 05;269(31):19731-7.
Free Article

Driving forces and substrate specificity for transport of reduced glutathione (GSH) across rat liver cell canalicular membrane were examined in vesicles isolated from this plasma membrane domain. In contrast to previous studies indicating a single saturable component of canalicular...

Temporal and dose-response features of monochlorobenzene hepatotoxicity in rats.

Fundamental and applied toxicology : official journal of the Society of Toxicology

Dalich GM, Larson RE.
PMID: 3987988
Fundam Appl Toxicol. 1985 Feb;5(1):105-16. doi: 10.1016/0272-0590(85)90054-5.

Time- and dose-dependent correlations of monochlorobenzene (CB) hepatotoxic effects were studied in view of (1) assumed mechanistic similarities to bromobenzene (BB), (2) the paucity of these data for CB, and (3) the relatively greater environmental importance of CB compared...

Hepatocellular bile acid transport and ursodeoxycholic acid hypercholeresis.

Digestive diseases and sciences

Scharschmidt BF, Lake JR.
PMID: 2689116
Dig Dis Sci. 1989 Dec;34(12):5S-15S. doi: 10.1007/BF01536656.

This review focuses on mechanisms of bile acid transport across the basolateral and canalicular hepatocyte plasma membranes and on ursodeoxycholic acid (UDCA) hypercholeresis and biotransformation. Conjugated trihydroxy bile acids enter hepatocytes via a sodium-coupled mechanism localized to the basolateral...

Bidirectional glutathione transport by cultured human retinal pigment epithelial cells.

Investigative ophthalmology & visual science

Lu SC, Sun WM, Nagineni CN, Hooks JJ, Kannan R.
PMID: 7591642
Invest Ophthalmol Vis Sci. 1995 Nov;36(12):2523-30.

PURPOSE: To characterize glutathione (GSH) transport by cultured human retinal pigment epithelial (HRPE) cells.METHODS: Cultured HRPE cells were pretreated with acivicin for GSH efflux and with buthionine sulfoximine for GSH uptake to prevent the breakdown and resynthesis of GSH....

Carrier-mediated uptake of lucifer yellow in skate and rat hepatocytes: a fluid-phase marker revisited.

The American journal of physiology

Ballatori N, Hager DN, Nundy S, Miller DS, Boyer JL.
PMID: 10516157
Am J Physiol. 1999 Oct;277(4):G896-904. doi: 10.1152/ajpgi.1999.277.4.G896.

Uptake of lucifer yellow (LY), a fluorescent disulfonic acid anionic dye, was studied in isolated skate (Raja erinacea) perfused livers and primary hepatocytes to evaluate its utility as a fluid-phase marker in these cells. However, our findings demonstrated that...

Showing 1 to 12 of 3415 entries