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Showing 1 to 12 of 383 entries
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Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.

World journal of gastrointestinal pharmacology and therapeutics

Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE.
PMID: 26558155
World J Gastrointest Pharmacol Ther. 2015 Nov 06;6(4):213-22. doi: 10.4292/wjgpt.v6.i4.213.

AIM: To evaluate the effect of orally administered plecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.METHODS: The cyclic guanosine monophosphate (cGMP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma...

Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations.

Allergy, asthma & immunology research

Kaplan AP.
PMID: 28913986
Allergy Asthma Immunol Res. 2017 Nov;9(6):477-482. doi: 10.4168/aair.2017.9.6.477.

The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H₁-receptor blockers are typically employed up to 4 times a day. First-generation antihistamines, such as hydroxyzine...

[Not Available].

Therapie

Chaabane A, Aouam K, Fredj NB, Boughattas NA.
PMID: 27393273
Therapie. 2010 Nov-Dec;65(6):543-50. doi: 10.2515/therapie/2010072.

AIM: Study the epidemiological, clinical, biological and chronological drug rash with eosinophilia and systemic symptoms (DRESS) characteristic and indicate the implicated drugs.METHODS: We carried a retrospective study including all DRESS cases notified to the Pharmacovigilance Unit of Monastir.RESULTS: Our...

Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver.

Toxicological research

Heidari R, Esmailie N, Azarpira N, Najibi A, Niknahad H.
PMID: 27123164
Toxicol Res. 2016 Apr;32(2):133-40. doi: 10.5487/TR.2016.32.2.133. Epub 2016 Apr 30.

Sulfasalzine is a widely administered drug against inflammatory-based disorders in human. However several cases of liver injury are associated with its administration. There is no stabilized safe protective agent against sulfasalazine-induced liver injury. Current investigation was designed to evaluate...

Modulation of Apoptosis and Differentiation by the Treatment of Sulfasalazine in Rabbit Articular Chondrocytes.

Toxicological research

Lee WK, Kang JS.
PMID: 27123162
Toxicol Res. 2016 Apr;32(2):115-21. doi: 10.5487/TR.2016.32.2.115. Epub 2016 Apr 30.

This study was conducted to examine the cellular regulatory mechanisms of sulfasalazine (SSZ) in rabbit articular chondrocytes treated with sodium nitroprusside (SNP). Cell phenotype was determined, and the MTT assay, Western blot analysis and immunofluorescence staining of type II...

Usefulness of sulfasalazine for patients with refractory-ulcerative colits.

BMJ open gastroenterology

Yoshino T, Sono M, Yazumi S.
PMID: 27648296
BMJ Open Gastroenterol. 2016 Aug 16;3(1):e000103. doi: 10.1136/bmjgast-2016-000103. eCollection 2016.

BACKGROUND: Patients with refractory-ulcerative colitis (UC) require therapy escalation. Sulfasalazine (SASP) could deliver a high concentration of 5-aminosalicylic acid to the colon. The usefulness of SASP for refractory-UC patients, however, is unclear.AIM: The aim was to evaluate the usefulness...

xCT expression modulates cisplatin resistance in Tca8113 tongue carcinoma cells.

Oncology letters

Zhang P, Wang W, Wei Z, Xu LI, Yang X, DU Y.
PMID: 27347143
Oncol Lett. 2016 Jul;12(1):307-314. doi: 10.3892/ol.2016.4571. Epub 2016 May 16.

Tongue squamous cell carcinoma (TSCC), which is a subtype of head and neck cancer, is the most common type of oral cancer. Due to its high recurrence rate and chemoresistance, the average survival rate for patients with TSCC remains...

Modulation of Gut Microbiome Composition and Function in Experimental Colitis Treated with Sulfasalazine.

Frontiers in microbiology

Zheng H, Chen M, Li Y, Wang Y, Wei L, Liao Z, Wang M, Ma F, Liao Q, Xie Z.
PMID: 28936203
Front Microbiol. 2017 Sep 07;8:1703. doi: 10.3389/fmicb.2017.01703. eCollection 2017.

Inflammatory bowel disease (IBD) results from alterations in intestinal flora and the immune system. Sulfasalazine (SASP) is a sulfa antimicrobial used to treat IBD in clinic for years. However, how SASP affects gut microbes and its potential functions remains...

Requirement of NF-kappa B Activation in Different Mice Brain Areas during Long-Term Memory Consolidation in Two Contextual One-Trial Tasks with Opposing Valences.

Frontiers in molecular neuroscience

Salles A, Krawczyk MDC, Blake M, Romano A, Boccia MM, Freudenthal R.
PMID: 28439227
Front Mol Neurosci. 2017 Apr 07;10:104. doi: 10.3389/fnmol.2017.00104. eCollection 2017.

NF-kappa B is a transcription factor whose activation has been shown to be necessary for long-term memory consolidation in several species. NF-kappa B is activated and translocates to the nucleus of cells in a specific temporal window during consolidation....

Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis.

Current rheumatology reviews

Ogrendik M.
PMID: 26002454
Curr Rheumatol Rev. 2015;11(1):47-49. doi: 10.2174/1573397111666150522094821.

The role of oral bacteria in the etiology of ankylosing spondylitis (AS) is examined in this review. Periodontitis is related to AS to a significant degree, and periodontitis is significantly more prevalent in patients with AS. Anti-Pophyromonas gingivalis and...

Degradation Study on Sulfasalazine and a Validated HPLC-UV Method for its Stability Testing.

Scientia pharmaceutica

Saini B, Bansal G.
PMID: 24959403
Sci Pharm. 2014 Jan 12;82(2):295-306. doi: 10.3797/scipharm.1311-15. Print 2014.

Sulfasalazine (SSZ) was subjected to degradation under the conditions of hydrolysis (acid, alkali, and water), oxidation (30% H2O2), dry heat, and photolysis (UV-VIS light) in accordance with the ICH guidelines. An RP-HPLC method was developed to study the degradation...

Worsening of arthritis with antiretroviral therapy: the coexistence of rheumatoid arthritis and human immunodeficiency virus infection revisited.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

Siva C, Brasington RD.
PMID: 17039088
J Clin Rheumatol. 2001 Feb;7(1):42-6. doi: 10.1097/00124743-200102000-00010.

The observation of remission occurring in several rheumatoid arthritis (RA) patients who subsequently became infected with human immunodeficiency virus (HIV) suggested that these diseases are mutually exclusive. Subsequent case reports of progression of destructive rheumatoid arthritis, even with depleted...

Showing 1 to 12 of 383 entries